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Challenges associated with the demonstration of bioequivalence of intramammary products in ruminants
Autor:
C. Lainesse, Ted Whittem, Geof W. Smith, R. Gehring, S. Soback, Kirby Pasloske, Sarah A. Wagner
Publikováno v:
Journal of Veterinary Pharmacology and Therapeutics. 35:65-79
Lainesse, C., Gehring, R., Pasloske, K., Smith, G., Soback, S., Wagner, S., Whittem, T. Challenges associated with the demonstration of bioequivalence of intramammary products in ruminants. J. vet. Pharmacol. Therap. 35 (Suppl. 1), 65–79. This arti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00e0b3160af6e49717015185b66d792b
https://doi.org/10.1111/j.1365-2885.2012.01375.x
https://doi.org/10.1111/j.1365-2885.2012.01375.x
Publikováno v:
Journal of Veterinary Pharmacology and Therapeutics. 35:45-52
The purpose of this article is to discuss the numerous species-specific and route-specific factors that can influence the peak and extent of exposure of an active pharmaceutical ingredient as they relate to the demonstration of bioequivalence between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::422dcb44b01db57c4a3f756cc06a042a
https://doi.org/10.1111/j.1365-2885.2012.01365.x
https://doi.org/10.1111/j.1365-2885.2012.01365.x
Publikováno v:
Journal of Veterinary Pharmacology and Therapeutics. 35:31-37
For drug products not amenable to blood level studies, clinical endpoint studies have been used as an indirect measure of formulation difference in bioavailability between test and reference products. However, clinical endpoint studies are not as sen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29ec9c820f465b1fe07a8872c34d7755
https://doi.org/10.1111/j.1365-2885.2012.01366.x
https://doi.org/10.1111/j.1365-2885.2012.01366.x
Publikováno v:
Journal of Veterinary Pharmacology and Therapeutics. 30:387-393
The objectives of this in vitro study were to describe cytochrome-dependent metabolism of clomipramine in canine and feline microsomes, compare metabolic profiles between cats, rats and dogs, and investigate a potential gender-related difference in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14e0a9d1b49420de3142f202f8a2fad
https://doi.org/10.1111/j.1365-2885.2007.00893.x
https://doi.org/10.1111/j.1365-2885.2007.00893.x
Publikováno v:
Veterinary Record. 161:221-225
A one-step method for catheterising the jugular vein of cats for taking multiple blood samples was developed, with the aid of radiography, to determine an appropriate internal catheter length for adult cats. The effects of multiple blood sampling and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2712185372df1410a6841176eb125d45
https://doi.org/10.1136/vr.161.7.221
https://doi.org/10.1136/vr.161.7.221
Autor:
S. Modric, J.R.E. del Castillo, R. Claxton, Robert P. Hunter, J.W.L. Robinson, Monserrat Martínez, E. Bermingham, A. Lucas, R. Gehring, Ronald E. Baynes, K. Harshman, C. Lainesse, C. Cole
Publikováno v:
Journal of Veterinary Pharmacology and Therapeutics. 34:105-107
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::345a377913290bc239a9ff3aac713d71
https://doi.org/10.1111/j.1365-2885.2011.01281.x
https://doi.org/10.1111/j.1365-2885.2011.01281.x
Autor:
C. Lainesse
Publikováno v:
The AAPS journal. 14(4)
Considering the diversity in physiology between species and the numerous dosage forms that exist in veterinary drug products, there are numerous complex issues that arise from the development and regulation of veterinary drugs for food-producing and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1377e842cbc733063cc6b85b6fb220e1
https://pubmed.ncbi.nlm.nih.gov/22864669
https://pubmed.ncbi.nlm.nih.gov/22864669