Zobrazeno 1 - 10
of 1 133
pro vyhledávání: '"C. Lacasse"'
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-13 (2024)
Abstract Smac mimetic compounds (SMCs) are small molecule drugs that sensitize cancer cells to TNF-α-induced cell death and have multiple immunostimulatory effects through alterations in NF-κB signaling. The combination of SMCs with immunotherapies
Externí odkaz:
https://doaj.org/article/e7dfa93325ff4ad39a2ad7f101b6277c
Autor:
Arya Afsahi, Christopher M. Silvestri, Allyson E. Moore, Carly F. Graham, Kaylyn Bacchiochi, Martine St-Jean, Christopher L. Baker, Robert G. Korneluk, Shawn T. Beug, Eric C. LaCasse, Jonathan L. Bramson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundThe genesis of SMAC mimetic drugs is founded on the observation that many cancers amplify IAP proteins to facilitate their survival, and therefore removal of these pathways would re-sensitize the cells towards apoptosis. It has become incre
Externí odkaz:
https://doaj.org/article/eb5ca895b54b482fb6cf4a6da61045ce
Autor:
Neena Lala-Tabbert, Rim Lejmi-Mrad, Kristen Timusk, Marina Fukano, Janelle Holbrook, Martine St-Jean, Eric C. LaCasse, Robert G. Korneluk
Publikováno v:
Skeletal Muscle, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract Background Skeletal muscle atrophy is a pathological condition that contributes to morbidity in a variety of conditions including denervation, cachexia, and aging. Muscle atrophy is characterized as decreased muscle fiber cross-sectional are
Externí odkaz:
https://doaj.org/article/c2c177ddccd1405a9f6a8140cf28c232
Autor:
Shawn T. Beug, Stephanie J. Pichette, Martine St-Jean, Janelle Holbrook, Danielle E. Walker, Eric C. LaCasse, Robert G. Korneluk
Publikováno v:
Molecular Therapy: Oncolytics, Vol 10, Iss , Pp 28-39 (2018)
Smac mimetic compounds (SMCs) are anti-cancer drugs that antagonize Inhibitor of Apoptosis proteins, which consequently sensitize cancer cells to death in the presence of proinflammatory ligands such as tumor necrosis factor alpha (TNF-α). SMCs syne
Externí odkaz:
https://doaj.org/article/c281d7e68df84c8fb966b20430c6a8ba
Autor:
Shawn T. Beug, Caroline E. Beauregard, Cristin Healy, Tarun Sanda, Martine St-Jean, Janelle Chabot, Danielle E. Walker, Aditya Mohan, Nathalie Earl, Xueqing Lun, Donna L. Senger, Stephen M. Robbins, Peter Staeheli, Peter A. Forsyth, Tommy Alain, Eric C. LaCasse, Robert G. Korneluk
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Smac mimetics sensitize cancer cells to the extrinsic cell death pathway and stimulate anti-tumour immunity. In this study, the authors show that Smac mimetics can synergize with immune checkpoint inhibitors to control tumour growth in mouse cancer m
Externí odkaz:
https://doaj.org/article/153f1f0b72134cffba06e3aad0670491
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 4 (2019)
A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells. In concert wi
Externí odkaz:
https://doaj.org/article/786c185c4b1746e197bb7199ee8e9d32
Supplementary Figures 1-6, Tables 1-2, Methods from Down-regulation of c-FLIP Enhances Death of Cancer Cells by Smac Mimetic Compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6ab4a0b56d118c89c6b49d0c42e809
https://doi.org/10.1158/0008-5472.22382655.v1
https://doi.org/10.1158/0008-5472.22382655.v1
Smac mimetic compounds (SMC) are novel small molecules being developed for cancer therapy. The mechanism of SMC-induced sensitivity in cancer cells depends on autocrine release of tumor necrosis factor α (TNFα); however, potential mechanisms of res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a8107ee8c237bb511bc3de5b9f1e38c
https://doi.org/10.1158/0008-5472.c.6500274
https://doi.org/10.1158/0008-5472.c.6500274
Autor:
Virginia Morón-Calvente, Salvador Romero-Pinedo, Sofía Toribio-Castelló, Julio Plaza-Díaz, Ana C Abadía-Molina, Domingo I Rojas-Barros, Shawn T Beug, Eric C LaCasse, Alex MacKenzie, Robert Korneluk, Francisco Abadía-Molina
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193643 (2018)
Monocytes and macrophages constitute the first line of defense of the immune system against external pathogens. Macrophages have a highly plastic phenotype depending on environmental conditions; the extremes of this phenotypic spectrum are a pro-infl
Externí odkaz:
https://doaj.org/article/6e6c5904483c442f977230c5dce64af9
Autor:
Michael P. Ward, C Lacasse, A Giles, M Allen, David N. Phalen, Jane Hall, Karrie Rose, Laura A. Pulscher
Publikováno v:
Australian Veterinary Journal
Objective To report the temporal and spatial distribution of rainbow lorikeets presenting with lorikeet paralysis syndrome (LPS) and their clinicopathologic and pathologic findings, exposure to toxins, and response to treatment. Methods Records of lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe096e5c9da5334c2d55b3c0e1770f8
https://doi.org/10.1111/avj.13107
https://doi.org/10.1111/avj.13107