Zobrazeno 1 - 10
of 21
pro vyhledávání: '"C. L. Weinstein"'
Publikováno v:
Journal of Crohn's and Colitis. 16:i114-i115
Background In a previous real-world study of long-term (up to 4 years) treatment with golimumab (GLM) in ulcerative colitis (UC), patients reported a low overall colectomy incidence (5.8%).1 This analysis evaluates the incidence of colectomy among pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ea0534e0dc4bcf15e56850625ce8b1a
https://doi.org/10.1093/ecco-jcc/jjab232.110
https://doi.org/10.1093/ecco-jcc/jjab232.110
Autor:
M, Goggins, M, Schutte, J, Lu, C A, Moskaluk, C L, Weinstein, G M, Petersen, C J, Yeo, C E, Jackson, H T, Lynch, R H, Hruban, S E, Kern
Publikováno v:
Cancer research. 56(23)
Germline mutations in BRCA2 predispose carriers to the development of breast, ovarian, and a variety of other cancers. The original localization of the BRCA2 gene was aided by its homozygous deletion in a pancreatic carcinoma; indeed, an excess of pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91fb96ee25d561b64d9bd2a84687cb61
https://pubmed.ncbi.nlm.nih.gov/8968085
https://pubmed.ncbi.nlm.nih.gov/8968085
Autor:
M, Schutte, R H, Hruban, L, Hedrick, K R, Cho, G M, Nadasdy, C L, Weinstein, G S, Bova, W B, Isaacs, P, Cairns, H, Nawroz, D, Sidransky, R A, Casero, P S, Meltzer, S A, Hahn, S E, Kern
Publikováno v:
Cancer research. 56(11)
We recently identified a novel tumor-suppressor gene, DPC4, at chromosome 18q21.1 and found that both alleles of DPC4 were inactivated in nearly one-half of the pancreatic carcinomas. Here, we analyzed 338 tumors, originating from 12 distinct anatomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::08962e9bbe38dbca69366533f70e61fb
https://pubmed.ncbi.nlm.nih.gov/8653691
https://pubmed.ncbi.nlm.nih.gov/8653691
Autor:
S A, Hahn, A T, Hoque, C A, Moskaluk, L T, da Costa, M, Schutte, E, Rozenblum, A B, Seymour, C L, Weinstein, C J, Yeo, R H, Hruban, S E, Kern
Publikováno v:
Cancer research. 56(3)
Absolute genetic differences between neoplastic and nonneoplastic cells can be discerned at sites of homozygous deletions. These deletions are of critical interest because they might be useful in the identification of defective biochemical pathways i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ea254300dc688dbe1171dbac786bcbd
https://pubmed.ncbi.nlm.nih.gov/8564959
https://pubmed.ncbi.nlm.nih.gov/8564959
Autor:
Charles J. Yeo, Ester Rozenblum, Mieke Schutte, Aryeh Fischer, Luis T. da Costa, Scott E. Kern, Christopher A. Moskaluk, C. L. Weinstein, A. T. M. Shamsul Hoque, Ralph H. Hruban, Stephan A. Hahn
Publikováno v:
Science (New York, N.Y.). 271(5247)
About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To identify candidate tumor suppressor genes on 18q, a panel of pancreatic carcinomas were analyzed for convergent sites of homozygous deletion. Twenty-five of 84 tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004c327be31d088df91f58d5588fe3c7
https://pubmed.ncbi.nlm.nih.gov/8553063
https://pubmed.ncbi.nlm.nih.gov/8553063
Autor:
Mieke Schutte, J.M. Trent, Ester Rozenblum, Hoque At, L T da Costa, M. Bittner, C. L. Weinstein, Christopher A. Moskaluk, Stephan A. Hahn, Paul S. Meltzer
Homozygous deletions have been central to the discovery of several tumor-suppressor genes, but their finding has often been either serendipitous or the result of a directed search. A recently described technique [Lisitsyn, N., Lisitsyn, N. & Wigler,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64224a3af0aa0e600f884283739ce91
https://europepmc.org/articles/PMC41619/
https://europepmc.org/articles/PMC41619/
Autor:
Charles J. Yeo, Ralph H. Hruban, Scott E. Kern, A. B. Seymour, Mieke Schutte, Stephan A. Hahn, Carlos Caldas, Mark Redston, L T da Costa, C. L. Weinstein
Publikováno v:
Nature genetics. 8(1)
The MTS1 gene on chromosome 9p21 encodes the p16 inhibitor of cyclinD/Cdk-4 complexes, and is deleted or mutated in a variety of tumour types. We found allelic deletions of 9p21-p22 in 85% of pancreatic adenocarcinomas. Analysis of MTS1 in pancreatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7b69496b09ace69471b158b935bb2f
https://pubmed.ncbi.nlm.nih.gov/7726912
https://pubmed.ncbi.nlm.nih.gov/7726912
Autor:
Carlos Caldas, Ralph H. Hruban, Mieke Schutte, Stephan A. Hahn, C. L. Weinstein, Charles J. Yeo, L T da Costa, A. B. Seymour, Mark Redston, Scott E. Kern
Publikováno v:
Nature Genetics. 8:410-410
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2458482f9603054c733dca121feb69b6
https://doi.org/10.1038/ng1294-410c
https://doi.org/10.1038/ng1294-410c
Autor:
O W Griffith, C L Weinstein
Publikováno v:
Journal of Biological Chemistry. 262:7254-7263
Cysteinesulfinate decarboxylase, purified from male rat livers and homogeneous by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, is resolved into five distinct enzyme species (isoforms) by gel isoelectric focusing. Since the isoforms are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::738ecb95832b457deae1c5c7697dbeb3
https://doi.org/10.1016/s0021-9258(18)48231-2
https://doi.org/10.1016/s0021-9258(18)48231-2
Publikováno v:
Journal of Biological Chemistry. 263:16568-16579
Although several pathways contribute to the catabolism of L-cysteine, the products formed are few--taurine + CO2 and pyruvate + ammonia + sulfate. L-Cysteinesulfinate is a key intermediate that is either decarboxylated to ultimately yield taurine or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ba1315b2f2dcdeb4d01104d0d686bd9
https://doi.org/10.1016/s0021-9258(18)37428-3
https://doi.org/10.1016/s0021-9258(18)37428-3