Výsledky vyhledávání - "C. L. Nichols"

In vivo antitumor activity of a panel of four monoclonal antibody-vinca alkaloid immunoconjugates which bind to three distinct epitopes of carcinoembryonic antigen

Autor: S L Briggs, Hinson Na, Corvalan, C L Nichols, James J. Starling, Smith W, Maciak Rs, Bennett C. Laguzza

Publikováno v: Bioconjugate Chemistry. 3:315-322

A panel of four murine monoclonal antibodies apparently directed against three distinct epitopes of carcinoembryonic antigen (CEA) was conjugated via oxidized carbohydrate groups to 4-desacetylvinblastine-3-carboxyhydrazide. The resulting antibody-vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7379f2a0193924815dc44abd9c767c28
https://doi.org/10.1021/bc00016a010

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Protein conjugates of defined structure: synthesis and use of a new carrier molecule

Autor: Meunier A, Vilaseca La, Robin E. Offord, W. L. Scott, Keith Rose, R. Werlen, C. L. Nichols

Publikováno v: Bioconjugate chemistry. 4(6)

A new carrier molecule, NH2OCH2CO-(Gly)3-[Lys(H-Ser-)]5-Gly-OH, has been synthesized to facilitate the preparation of protein conjugates of defined structure. Special features are as follows: (i) (aminooxy)-acetyl as a terminal group, which reacts sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2bcf2268cf990f6a668b958f6e2b9e
https://pubmed.ncbi.nlm.nih.gov/8305521

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Progress in the medicinal chemistry of dopaminergic agents

Autor: J M, Schaus, E C, Kornfeld, R D, Titus, C L, Nichols, D L, Huser, J A, Clemens, E B, Smalstig, R W, Fuller

Publikováno v: Drug design and discovery. 9(3-4)

Ergot alkaloids and their derivatives have long been recognized for their potent pharmacologic activity. A number of ergot derivatives, including the dopamine agonists bromocriptine and pergolide, are currently in clinical use for the treatment of CN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf71bd433f1388d5737df81bf2b2e19b
https://pubmed.ncbi.nlm.nih.gov/8104521

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THE INTERNATIONAL HYDROGRAPHIC BUREAU

Autor: C. L. Nichols

Publikováno v: Navigation. 3:89-93

The Principality of Monaco, of which Monte-Carlo is a part, is inevitably associated in the public mind with the froth of life, as a place where it is better to be decorative than useful. Yet, despite this almost universally accepted view of Monte-Ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f63a6af7ec310fd45555034e69f534a
https://doi.org/10.1002/j.2161-4296.1952.tb00628.x

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Preclinical studies on quinelorane, a potent and highly selective D2-dopaminergic agonist

Autor: M M, Foreman, R W, Fuller, M D, Hynes, J S, Gidda, C L, Nichols, J M, Schaus, E C, Kornfeld, J A, Clemens

Publikováno v: The Journal of pharmacology and experimental therapeutics. 250(1)

Quinelorane (LY163502) has the endocrine, neurochemical and behavioral profile of a potent and highly selective D2-dopaminergic agonist. The administration of quinelorane produced dose-related decreases in serum prolactin concentration of reserpinize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::36fe171d4da6745efc6a17067a6d68a1
https://pubmed.ncbi.nlm.nih.gov/2526214

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New antitumor monoclonal antibody-vinca conjugates LY203725 and related compounds: design, preparation, and representative in vivo activity

Autor: George Joseph Cullinan, Bennett C. Laguzza, J. R. F. Corvalan, T. F. Bumol, C L Nichols, James J. Starling, Stephen L. Briggs, David W. Johnson, A. L. Baker

Publikováno v: Journal of medicinal chemistry. 32(3)

A method has been developed to allow the direct coupling of the cytotoxic vinca alkaloid 4-desacetylvinblastine-3-carbohydrazide (DAVLB hydrazide) to a variety of murine monoclonal antibodies directed against human solid tumors. Periodate oxidation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07043334e4247f79de9a939bae05d14f
https://pubmed.ncbi.nlm.nih.gov/2783975

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In vivo efficacy of monoclonal antibody ? drug conjugates of three different subisotypes which bind the human tumor ? associated antigen defined by the KS1/4 monoclonal antibody

Autor: S L Briggs, Bennett C. Laguzza, C L Nichols, James J. Starling, Hinson Na, Maciak Rs

Publikováno v: Cancer Immunology Immunotherapy. 28

A panel of three hybridomas has been isolated each of which secretes a single species of monoclonal antibody (MoAb) directed against the KS1/4 tumor-associated antigen originally described by Varki et al. (Cancer Res 44: 681, 1984). These MoAbs were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9af64f639c87df0d3aefbc56b6e4cb
https://doi.org/10.1007/bf00204985

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Elevation of acetylcholine levels in striatum of rat brain by LY163502, trans-(-)-5,5a,6,7,8,9a,10-octahydro-6-propylpyrimido less than 4,5-g greater than quinolin-2-amine dihydrochloride, a potent and stereospecific dopamine (D2) agonist

Autor: F P, Bymaster, L R, Reid, C L, Nichols, E C, Kornfeld, D T, Wong

Publikováno v: Life sciences. 38(4)

LY163502, a partial ergoline and a trans-levorotatory enantiomer, does not stimulate adenylate cyclase in striatal membranes but inhibits 50% binding of 3H-apomorphine, 3H-pergolide and 3H-spiperone at 10, 13 and 151 nM (IC50), respectively. The race

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::45749642261431bd46d12eba40a5d353
https://pubmed.ncbi.nlm.nih.gov/3753738

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