Výsledky vyhledávání - "C. L. Martel"

Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid β in guinea pigs

Autor: J. B. Mackic, J G McComb, C. L. Martel, Jorge Ghiso, Berislav V. Zlokovic

Publikováno v: Neuroscience Letters. 206:157-160

An intracarotid brain infusion/capillary depletion technique was used in guinea pigs to examine cerebral capillary sequestration and transport into brain parenchyma of sA beta 1-40 and sA beta 1-42, synthetic peptides identical to two forms of the am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8890be6cbdc75f7eb5033f39bece110
https://doi.org/10.1016/s0304-3940(96)12462-9

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Autor: Berislav V. Zlokovic, Martin H. Weiss, J. B. Mackic, J G McComb, C. L. Martel, J. D. Adams

Publikováno v: Pharmaceutical Research. 13:290-295

Purpose. Transport of dopamine (DA) across the blood-brain barrier (BBB) was examined in guinea pigs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93ed62294e9b3cd7935634ed80dbb818
https://doi.org/10.1023/a:1016007601794

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Brain Uptake of Circulating Apolipoproteins J and E Complexed to Alzheimer′s Amyloid β

Autor: C. L. Martel, J G McComb, Jorge Ghiso, Berislav V. Zlokovic, J. B. Mackic, Thomas Wisniewski, B. Frangione, E. Matsubara

Publikováno v: Biochemical and Biophysical Research Communications. 205:1431-1437

Amyloid beta (A beta) is a fibrillar component in Alzheimers' disease amyloid deposits and a soluble peptide (sA beta) normally present in body fluids. We have recently reported that the blood-brain barrier (BBB) has a capability to control cerebrova

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52333e531297a2dd7bfb4bdeb9f8a490
https://doi.org/10.1006/bbrc.1994.2825

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Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers

Autor: Jorge Ghiso, C. L. Martel, J G McComb, B. Frangione, G Zheng, Etsuro Matsubara, Berislav V. Zlokovic, R T McCluskey

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 93(9)

A soluble form of Alzheimer disease amyloid beta-protein (sA beta) is transported in the blood and cerebrospinal fluid mainly complexed with apolipoprotein J (apoJ). Using a well-characterized in situ perfused guinea pig brain model, we recently obta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21e2c4fb0345386660e198a835c6adf
https://pubmed.ncbi.nlm.nih.gov/8633046

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Transport of dopamine at the blood-brain barrier of the guinea pig: inhibition by psychotropic drugs and nicotine

Autor: C L, Martel, J B, Mackic, J D, Adams, J G, McComb, M H, Weiss, B V, Zlokovic

Publikováno v: Pharmaceutical research. 13(2)

Transport of dopamine (DA) across the blood-brain barrier (BBB) was examined in guinea pigs.In situ brain perfusion (1-10 min), capillary depletion, and high pressure liquid chromatography (HPLC) were used.There was a saturable DA influx into the bra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b118b39e00080454b60d1826e0cf2ecc
https://pubmed.ncbi.nlm.nih.gov/8932451

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The use of panitumumab (Pan) in patients (pts) with metastatic colorectal carcinoma (CRC) whose disease has progressed through treatment (Rx) with cetuximab (Cet)

Autor: M. V. McNamara, C. L. Martel

Publikováno v: Journal of Clinical Oncology. 27:e15142-e15142

e15142 Background: Both Pan and Cet have activity in the Rx of metastatic CRC. As they each target the epidermal growth factor receptor, and are believed to have the same mechanism of action, pts who fail Rx with one of these agents are generally not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b73dc697e0dd780158fe5d611ebe0d5
https://doi.org/10.1200/jco.2009.27.15_suppl.e15142

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Heterogeneous monitoring for and management of bevacizumab (BE) toxicity (T): Develpment of standardized guidelines for monitoring (mon) and treatment (tre) of the BE toxicity syndrome (BETS)

Autor: M. J. Vakil, G. Upadhyaya, Linda D. Bosserman, C. L. Martel, Cary A. Presant, B. Ebrahimi, R. C. Horns

Publikováno v: Journal of Clinical Oncology. 23:8224-8224

8224 Background: BE is widely used for managing metastatic colorectal cancer and is in widespread trials including breast, lung, renal and lymphoid malignancies. Analysis of patients (pts) receivin...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5f17cdfad563f16066580a149ad32a4
https://doi.org/10.1200/jco.2005.23.16_suppl.8224

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Development and implementation of effective quality (Q) guidelines (G) in community (com) cancer centers (CC): The cancer quality program (CQP)

Autor: R. C. Horns, G. Upadhyaya, M. D. Scalia, B. Ebrahimi, Christina Yeon, Linda D. Bosserman, C. L. Martel, M. J. Vakil, T. Young, Cary A. Presant

Publikováno v: Journal of Clinical Oncology. 23:6105-6105

6105 Background: National panels, institutes, and media have accused oncology of poor Q in patient (pt) care. In order to improve Q in com pt care, we developed the CQP. Methods: 8 oncologists and ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e7d40fb485fb1a38bb3ca352c47c2e6
https://doi.org/10.1200/jco.2005.23.16_suppl.6105

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Incidence of bevacizumab (BE) related toxicities: Association of hypertension (HTN) and proteinuria (PTN), a BE toxicity syndrome (BETS)

Autor: Linda D. Bosserman, R. C. Horns, G. Upadhyaya, M. J. Vakil, Christina Yeon, Cary A. Presant, B. Ebrahimi, C. L. Martel

Publikováno v: Journal of Clinical Oncology. 23:8062-8062

8062 Background: BE, a monoclonal antibody that inhibits VEGF, prolongs survival in patients (pts) with metastatic colorectal cancer treated with 5FU chemotherapy. However, BE is associated with HT...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a132d774b4e9dce16114900546d56603
https://doi.org/10.1200/jco.2005.23.16_suppl.8062

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Increasing accrual (Ac) to clinical trials (CT) in community cancer clinics (CCC): A successful method using electronic medical records (EMR), virtual private network (VPN) and focused group activities (FGA)

Autor: T. Young, B. Ebrahimi, M. D. Scalia, Cary A. Presant, Linda D. Bosserman, C. L. Martel, G. Upadhyaya, R. C. Horns, Christina Yeon, M. J. Vakil

Publikováno v: Journal of Clinical Oncology. 23:6088-6088

6088 Background: Patient (pt) participation in CT is below expectations. Our CCC offers CT’s through research networks, industry and investigator initiated trials and sought to maximize Ac. We used...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06f76dc848ff04ab49f3dea9c5e5140c
https://doi.org/10.1200/jco.2005.23.16_suppl.6088

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