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Akademický článek

Alcohol consumption patterns and HIV viral suppression among persons receiving HIV care in Florida: an observational study

Autor: R. L. Cook, Z. Zhou, N. E. Kelso-Chichetto, J. Janelle, J. P. Morano, C. Somboonwit, W. Carter, G. E. Ibanez, N. Ennis, C. L. Cook, R. A. Cohen, B. Brumback, K. Bryant

Publikováno v: Addiction Science & Clinical Practice, Vol 12, Iss 1, Pp 1-9 (2017)

Abstract Background Alcohol consumption has been associated with poor antiretroviral therapy (ART) adherence but less is known about its relationship to HIV viral suppression, or whether certain drinking patterns have a stronger association than othe

Externí odkaz: https://doaj.org/article/5647938cde7243bd8bc10f879008f5e6

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Akademický článek

Resistance to Experimental Visceral Leishmaniasis in Mice Infected With Leishmania infantum Requires Batf3

Autor: Manuel Soto, Laura Ramírez, José Carlos Solana, Emma C. L. Cook, Elena Hernández-García, Sara Charro-Zanca, Ana Redondo-Urzainqui, Rosa M. Reguera, Rafael Balaña-Fouce, Salvador Iborra

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Unveiling the protective immune response to visceral leishmaniasis is critical for a rational design of vaccines aimed at reducing the impact caused by this fatal, if left untreated, vector-borne disease. In this study we sought to determine the role

Externí odkaz: https://doaj.org/article/1cd9da7914a5439fb638bc474ea1d91f

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Akademický článek

Inoculation of the Leishmania infantum HSP70-II Null Mutant Induces Long-Term Protection against L. amazonensis Infection in BALB/c Mice

Autor: Manuel Soto, Laura Ramírez, José Carlos Solana, Emma C. L. Cook, Elena Hernández-García, José María Requena, Salvador Iborra

Publikováno v: Microorganisms, Vol 9, Iss 2, p 363 (2021)

Leishmania amazonensis parasites are etiological agents of cutaneous leishmaniasis in the New World. BALB/c mice are highly susceptible to L. amazonensis challenge due to their inability to mount parasite-dependent IFN-γ-mediated responses. Here, we

Externí odkaz: https://doaj.org/article/1e1f9c549885430d9f3ae14f5a30a15d

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Conventional type 1 dendritic cells protect against age-related adipose tissue dysfunction and obesity

Autor: Elena Hernández-García, Francisco J. Cueto, Emma C. L. Cook, Ana Redondo-Urzainqui, Sara Charro-Zanca, Iñaki Robles-Vera, Ruth Conde-Garrosa, Ivana Nikolić, Guadalupe Sabio, David Sancho, Salvador Iborra

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
Cellular and Molecular Immunology

Conventional dendritic cells (cDCs) scan and integrate environmental cues in almost every tissue, including exogenous metabolic signals. While cDCs are critical in maintaining immune balance, their role in preserving energy homeostasis is unclear. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b8365d0c9466e55e63f4a0a506bd04
http://hdl.handle.net/20.500.12105/15098

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Differential use of E2 ubiquitin conjugating enzymes for regulated degradation of the rate-limiting enzymes HMGCR and SQLE in cholesterol biosynthesis

Autor: Anke Loregger, Marlene van den Berg, Emma C. L. Cook, Josephine M. E. Tan, Saskia Scheij, Noam Zelcer

Publikováno v: Atherosclerosis, 281, 137-142. Elsevier Ireland Ltd

Background and aims Cholesterol is an essential lipid for cellular function and membrane integrity, and hence its cellular levels and distribution must be tightly regulated. Biosynthesis of cholesterol is ramped when its cellular levels are low. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa9ce3a73f55780da0ae0725d0cabb3
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85059899532&origin=inward

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Inoculation of the Leishmania infantum HSP70-II Null Mutant Induces Long-Term Protection against L. amazonensis Infection in BALB/c Mice

Autor: Emma C. L. Cook, Laura Ramírez, Salvador Iborra, José Carlos Solana, Jose M. Requena, Manuel Soto, Elena Hernández-García

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Digital.CSIC. Repositorio Institucional del CSIC
Microorganisms, Vol 9, Iss 363, p 363 (2021)
Microorganisms
Volume 9
Issue 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852f02e07910f7c4e044be894ea742d2
http://hdl.handle.net/20.500.12105/12847

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Resistance to Experimental Visceral Leishmaniasis in Mice Infected With Leishmania infantum Requires Batf3

Autor: Sara Charro-Zanca, Rosa M. Reguera, Salvador Iborra, Ana Redondo-Urzainqui, Rafael Balaña-Fouce, Emma C. L. Cook, Laura Ramírez, Elena Hernández-García, Manuel Soto, José Carlos Solana

Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Frontiers in Immunology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddabd9fb8036654b469b10de48a8c3ef
https://www.frontiersin.org/articles/10.3389/fimmu.2020.590934/full

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SHP-1 Regulates Antigen Cross-Presentation and Is Exploited by Leishmania to Evade Immunity

Autor: María Martínez-López, Emma C. L. Cook, Elena Hernández-García, Sofía C. Khouili, Salvador Iborra, Ruth Conde-Garrosa

Publikováno v: Cell Reports, Vol 33, Iss 9, Pp 108468-(2020)
Repisalud
Instituto de Salud Carlos III (ISCIII)

Intracellular pathogens have evolved strategies to evade detection by cytotoxic CD8+ T lymphocytes (CTLs). Here, we ask whether Leishmania parasites trigger the SHP-1-FcRγ chain inhibitory axis to dampen antigen cross-presentation in dendritic cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d9ee02aced76038f76543b1711d039
https://pubmed.ncbi.nlm.nih.gov/33264612

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Leishmania Triggering of SHP-1 in Dendritic Cells Inhibits Antigen Cross-Presentation to Cd8 + T Cells

Autor: Sofía C. Khouili, Ruth Conde-Garrosa, Elena Hernández-García, Salvador Iborra, Emma C. L. Cook, María Martínez-López

Publikováno v: SSRN Electronic Journal.

Pathogens that establish intracellular niches may have evolved strategies to prevent their detection by cytotoxic CD8+ T lymphocytes (CTL), which in some cases requires antigen cross-presentation by dendritic cells (DC). Here, we asked whether Leishm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fbd9e3c908c56520dcfb695c17a0ad3
https://doi.org/10.2139/ssrn.3645487

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Subcutaneous Immunization of Leishmania HSP70-II Null Mutant Line Reduces the Severity of the Experimental Visceral Leishmaniasis in BALB/c Mice

Autor: Emma C. L. Cook, Rafael Balaña-Fouce, Elena Hernández-García, Laura Ramírez, Elena M. Martin, Manuel Soto, Rosa M. Reguera, Manuel Fresno, Salvador Iborra, Víctor M. González, José Carlos Solana, Jose M. Requena, Silvia Sacristán

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
Vaccines, Vol 8, Iss 1, p 141 (2020)
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Vaccines
Volume 8
Issue 1

Leishmania infantum parasites cause a severe form of visceral leishmaniasis in human and viscerocutaneous leishmaniasis in dogs. Recently, we reported that immunization with an attenuated L. infantum cell line, lacking the hsp70-II gene, protects aga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f9585f6abf5e7991829545ffb7de21
http://hdl.handle.net/20.500.12105/9448

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