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Epilepsy in patients with GRIN2A alterations: Genetics, neurodevelopment, epileptic phenotype and response to anticonvulsive drugs

Autor: Gerhard Kluger, Konstanze Hoertnagel, Elena Piazza, Pierangelo Veggiotti, Ingo Borggraefe, K Stöhr, Elaine Hughes, M Ensslen, Till Hartlieb, C von Stülpnagel, C Kutzer, M Dreesmann, Deb K. Pal, Silvia Masnada, T Herberhold, Kevin Rostasy, Tobias B. Haack, J Nitanda, M Pohl, M Koch, Rikke S. Møller

Publikováno v: von Stülpnagel, C, Ensslen, M, Møller, R S, Pal, D K, Masnada, S, Veggiotti, P, Piazza, E, Dreesmann, M, Hartlieb, T, Herberhold, T, Hughes, A E, Koch, M, Kutzer, C, Hörtnagel, K, Nitanda, J, Pohl, M, Rostasy, K, Haack, T B, Stöhr, K, Kluger, G & Borggraefe, I 2017, ' Epilepsy in patients with GRIN2A alterations : Genetics, neurodevelopment, epileptic phenotype and response to anticonvulsive drugs ', European Journal of Paediatric Neurology, vol. 21, no. 3, pp. 530–541 . https://doi.org/10.1016/j.ejpn.2017.01.001

OBJECTIVE: To delineate the genetic, neurodevelopmental and epileptic spectrum associated with GRIN2A alterations with emphasis on epilepsy treatment.METHODS: Retrospective study of 19 patients (7 females; age: 1-38 years; mean 10.1 years) with epile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817edf1057c7a48f6ee69b7c589ab16e
https://doi.org/10.1016/j.ejpn.2017.01.001

Simultaneous Solid-Phase Extraction and Gas Chromatographic--Mass Spectrometric Determination of Hemoglobin Adducts from Tobacco-Specific Nitrosamines and Aromatic Amines

Autor: Birgit Branner, C. Kutzer, Elmar Richter, W. Zwickenpflug

Publikováno v: Journal of Chromatographic Science. 35:1-6

A new method for the simultaneous determination of hemoglobin adducts from aromatic amines and tobacco-specific nitrosamines (TSNA) is described. After mild base-catalysed hydrolysis releasing aromatic amines and the TSNA adduct 4-hydroxy-1-(3-pyridy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9abfc9ec42b2e7f0b5527a7cf960897
https://doi.org/10.1093/chromsci/35.1.1

Biomonitoring of hemoglobin adducts: aromatic amines and tobacco-specific nitrosamines

Autor: B. Falter, C. Kutzer, E. Richter

Publikováno v: The Clinical investigator. 72(5)

A new analytical procedure has been developed for the simultaneous determination of human hemoglobin adducts from aromatic amines and tobacco-specific nitrosamines. These tobacco-related hemoglobin adducts were determined in nonsmokers, smokers, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ddc655b1961de4b3e85109c875bcbb8
https://pubmed.ncbi.nlm.nih.gov/8086771

Pharmacokinetics and pharmacology of metabolites

Autor: F. Adlkofer, J. G. Besner, Alain Ravard, Peter A. Crooks, G. Singh, Jean-Louis Horn, Min Li, B. V. Rama Sastry, Neal L. Benowitz, A. R. Tricker, H. Klus, G. P. Dobson, Gerhard Scherer, Peyton Jacob, D. Doolittle, H. Taber, C. Kutzer, Gary D. Byrd, William S. Caldwell, C. Fulp, Dorothy K. Hatsukami, Elmar Richter, J.R. Idle, Donald deBethizy, Chin K. Lee, Bhatti Balwinder Singh, Julian B. S. Leathart, E. Johnstone, N. W. McCracken, S. E. Atawodi, D. J. deBethizv, K. Yan, M.B. Chance, Herb Severson, S. Cholerton, A. Arpanahi, John H. Robinson, M. Bouhajib, M Meger, G. M. Dull, Ann K. Daly, E. Bombick, V. E. Janson, A. Pachinger, Carol Boustead, Linda P. Dwoskin

Publikováno v: Experientia Supplementum ISBN: 9783764350871

Recently, we have shown a significantly lower excretion of α-hydroxylation products of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in the urine of rats co-administered a 500-fold higher dose of nicotine (Richter et al., Naunyn Schmiedebergs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae0cca7b2883718a039886b04c418158
https://doi.org/10.1007/978-3-0348-7416-8_20