Tumour necrosis factor-mediated homeostatic synaptic plasticity in behavioural models: testing a role in maternal immune activation

Autor: David Stellwagen, Sarah C. Konefal

The proinflammatory cytokine tumour necrosis factor-alpha (TNFα) has long been characterized for its role in the innate immune system, but more recently has been found to have a distinct role in the nervous system that does not overlap with other pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e990f387f47610636b038a7d57585c19
https://europepmc.org/articles/PMC5247592/

Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization

Autor: Keanan Augereau, Gil M. Lewitus, David Stellwagen, Horia Pribiag, Sarah C. Konefal, Andrew D. Greenhalgh

Publikováno v: Lewitus, G, Konefal, S, Greenhalgh, A, Pribiag, H, Augereau, K & Stellwagen, D 2016, ' Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization ', Neuron, vol. 90, no. 3, pp. 483-491 . https://doi.org/10.1016/j.neuron.2016.03.030

Repeated administration of cocaine results in the development of behavioral sensitization, accompanied by a decrease in excitatory synaptic strength in the nucleus accumbens (NAc) through an unknown mechanism. Furthermore, glial cells in the NAc are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7a184e602aa61846a9b43d01ee2ea8
https://linkinghub.elsevier.com/retrieve/pii/S0896627316300216