Zobrazeno 1 - 10
of 41
pro vyhledávání: '"C. Keith Cassidy"'
Autor:
T. Bertie Ansell, Wanling Song, Claire E. Coupland, Loic Carrique, Robin A. Corey, Anna L. Duncan, C. Keith Cassidy, Maxwell M. G. Geurts, Tim Rasmussen, Andrew B. Ward, Christian Siebold, Phillip J. Stansfeld, Mark S. P. Sansom
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Cryo-electron microscopy (cryo-EM) enables the determination of membrane protein structures in native-like environments. Characterising how membrane proteins interact with the surrounding membrane lipid environment is assisted by resolution
Externí odkaz:
https://doaj.org/article/cf3afb5f6f044bce9bcb06b11105b64c
Autor:
C. Keith Cassidy, Zhuan Qin, Thomas Frosio, Khoosheh Gosink, Zhengyi Yang, Mark S. P. Sansom, Phillip J. Stansfeld, John S. Parkinson, Peijun Zhang
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Motile bacteria employ conserved chemotaxis networks to detect chemical gradients in their surroundings and effectively regulate their locomotion, enabling the location of essential nutrients and other important biological niches. The sensor
Externí odkaz:
https://doaj.org/article/e150b6dfc911417aa1855dc8eac75765
Autor:
Ruochen Ouyang, Ana Rita Costa, C. Keith Cassidy, Aleksandra Otwinowska, Vera C. J. Williams, Agnieszka Latka, Phill J. Stansfeld, Zuzanna Drulis-Kawa, Yves Briers, Daniël M. Pelt, Stan J. J. Brouns, Ariane Briegel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The jumbo contractile bacteriophage, Kp24, has been isolated from clinical strains of Klebsiella pneumonia. Here, the authors present structural and functional insight into the capsid, tail and tail fibres and how this impacts infectivity.
Externí odkaz:
https://doaj.org/article/bff0aa3fd85c46f3a5c019f7cf4539c3
Autor:
Yanan Zhu, Christopher W. Koo, C. Keith Cassidy, Matthew C. Spink, Tao Ni, Laura C. Zanetti-Domingues, Benji Bateman, Marisa L. Martin-Fernandez, Juan Shen, Yuewen Sheng, Yun Song, Zhengyi Yang, Amy C. Rosenzweig, Peijun Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Particulate methane monooxygenase (pMMO) is the main enzyme used by methanotrophs. Here, the authors determined the native structure of pMMO by cryo-electron tomography, revealing lipid-stabilized features and a higher-order hexagonal array arrangeme
Externí odkaz:
https://doaj.org/article/a4c31e824df8458882d3c119c9e2d183
Autor:
Jamie S. Depelteau, Ludovic Renault, Nynke Althof, C. Keith Cassidy, Luiza M. Mendonça, Grant J. Jensen, Guenter P. Resch, Ariane Briegel
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-8 (2022)
Depelteau et al. present a new method to inactivate cryo-EM samples from pathogenic organisms before imaging using ultraviolet-C radiation in cryogenic conditions. This method allows for the inexpensive preparation of cryo-EM samples with no discerna
Externí odkaz:
https://doaj.org/article/3651c3a719c849cdb8bfa6131c0113f3
Autor:
Alister Burt, C. Keith Cassidy, Peter Ames, Maria Bacia-Verloop, Megghane Baulard, Karine Huard, Zaida Luthey-Schulten, Ambroise Desfosses, Phillip J. Stansfeld, William Margolin, John S. Parkinson, Irina Gutsche
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Motile bacteria sense chemical gradients with transmembrane receptors organised in supramolecular signalling arrays. Here authors introduce an E. coli strain that forms small minicells possessing extended and highly ordered chemosensory arrays that a
Externí odkaz:
https://doaj.org/article/67bf735156674e3d9244d39821a57351
Autor:
Arden Perkins, Dan A. Tudorica, Raphael D. Teixeira, Tilman Schirmer, Lindsay Zumwalt, O. Maduka Ogba, C. Keith Cassidy, Phillip J. Stansfeld, Karen Guillemin
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Immune cells are well equipped to eliminate invading bacteria, and one of their primary tools is the synthesis of bleach, hypochlorous acid (HOCl), the same chemical used as a household disinfectant. In this work, we present findings showing that man
Externí odkaz:
https://doaj.org/article/552441f439374f9fbe0178df8f79fafe
Autor:
Payman Tohidifar, Girija A. Bodhankar, Sichong Pei, C. Keith Cassidy, Hanna E. Walukiewicz, George W. Ordal, Phillip J. Stansfeld, Christopher V. Rao
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Motile bacteria sense chemical gradients using chemoreceptors, which consist of distinct sensing and signaling domains. The general model is that the sensing domain binds the chemical and the signaling domain induces the tactic response. Her
Externí odkaz:
https://doaj.org/article/063646b204624a6a963f9fa7b1e17a7b
Autor:
Wen Yang, C. Keith Cassidy, Peter Ames, Christoph A. Diebolder, Klaus Schulten, Zaida Luthey-Schulten, John S. Parkinson, Ariane Briegel
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT Tsr, the serine chemoreceptor in Escherichia coli, transduces signals from a periplasmic ligand-binding site to its cytoplasmic tip, where it controls the activity of the CheA kinase. To function, Tsr forms trimers of homodimers (TODs), whic
Externí odkaz:
https://doaj.org/article/847988807b03485c86b6cde17c501b41
Publikováno v:
Biomolecules, Vol 11, Iss 4, p 495 (2021)
Chemotactic responses in motile bacteria are the result of sophisticated signal transduction by large, highly organized arrays of sensory proteins. Despite tremendous progress in the understanding of chemosensory array structure and function, a struc
Externí odkaz:
https://doaj.org/article/4f3c553041d14a02a5c8248525ba0a0a