Zobrazeno 1 - 10 of 1 475 pro vyhledávání: '"C. Karagiannis"'
1
Akademický článek
Investigation of the Anti-Inflammatory Properties of Bioactive Compounds from Olea europaea: In Silico Evaluation of Cyclooxygenase Enzyme Inhibition and Pharmacokinetic Profiling
Autor: Tom C. Karagiannis, Katherine Ververis, Julia J. Liang, Eleni Pitsillou, Evan A. Kagarakis, Debbie T. Z. Yi, Vivian Xu, Andrew Hung, Assam El-Osta
Publikováno v: Molecules, Vol 29, Iss 15, p 3502 (2024)
In a landmark study, oleocanthal (OLC), a major phenolic in extra virgin olive oil (EVOO), was found to possess anti-inflammatory activity similar to ibuprofen, involving inhibition of cyclooxygenase (COX) enzymes. EVOO is a rich source of bioactive
Externí odkaz: https://doaj.org/article/29ec5c7a362745bcae6755908e6074a7
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2
Akademický článek
Identification and Evaluation of Olive Phenolics in the Context of Amine Oxidase Enzyme Inhibition and Depression: In Silico Modelling and In Vitro Validation
Autor: Tom C. Karagiannis, Katherine Ververis, Julia J. Liang, Eleni Pitsillou, Siyao Liu, Sarah M. Bresnehan, Vivian Xu, Stevano J. Wijoyo, Xiaofei Duan, Ken Ng, Andrew Hung, Erik Goebel, Assam El-Osta
Publikováno v: Molecules, Vol 29, Iss 11, p 2446 (2024)
The Mediterranean diet well known for its beneficial health effects, including mood enhancement, is characterised by the relatively high consumption of extra virgin olive oil (EVOO), which is rich in bioactive phenolic compounds. Over 200 phenolic co
Externí odkaz: https://doaj.org/article/e6fa27c2e71d42b0a3b170c21eb59163
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3
Akademický článek
Identification of Potential Modulators of a Pathogenic G Protein-Gated Inwardly Rectifying K+ Channel 4 Mutant: In Silico Investigation in the Context of Drug Discovery for Hypertension
Autor: Eleni Pitsillou, Alexander N. O. Logothetis, Julia J. Liang, Assam El-Osta, Andrew Hung, Asmaa S. AbuMaziad, Tom C. Karagiannis
Publikováno v: Molecules, Vol 28, Iss 24, p 7946 (2023)
Genetic abnormalities have been associated with primary aldosteronism, a major cause of secondary hypertension. This includes mutations in the KCNJ5 gene, which encodes G protein-gated inwardly rectifying K+ channel 4 (GIRK4). For example, the substi
Externí odkaz: https://doaj.org/article/1dffc6bc833241229cccb4868d521a98
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5
Akademický článek
Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy
Autor: Nadia Mazarakis, Jitraporn Vongsvivut, Keith R. Bambery, Katherine Ververis, Mark J. Tobin, Simon G. Royce, Chrishan S. Samuel, Kenneth J. Snibson, Paul V. Licciardi, Tom C. Karagiannis
Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract The ovalbumin-induced (OVA) chronic allergic airways murine model is a well-established model for investigating pre-clinical therapies for chronic allergic airways diseases, such as asthma. Here, we examined the effects of several experiment
Externí odkaz: https://doaj.org/article/0864f305e454477a82fdd3b364b6f67a
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6
Akademický článek
Identification of Small Molecule Inhibitors of the Deubiquitinating Activity of the SARS-CoV-2 Papain-Like Protease: in silico Molecular Docking Studies and in vitro Enzymatic Activity Assay
Autor: Eleni Pitsillou, Julia Liang, Katherine Ververis, Kah Wai Lim, Andrew Hung, Tom C. Karagiannis
Publikováno v: Frontiers in Chemistry, Vol 8 (2020)
COVID-19 is an ongoing pandemic caused by the SARS-CoV-2 virus with important political, socio-economic, and public health consequences. Inhibiting replication represents an important antiviral approach, and in this context two viral proteases, the S
Externí odkaz: https://doaj.org/article/f59f438c29274730b188467abd5c38ae
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7
Molecular insights into the interaction of apo-lactoferrin with the receptor binding domain of the SARS-CoV-2 spike protein: a molecular dynamics simulation study
Autor: Kevion K. Darmawan, Tom C. Karagiannis, Jeff G. Hughes, Darryl M. Small, Andrew Hung
Publikováno v: Journal of Biomolecular Structure and Dynamics. :1-14
LF is a bioactive protein, derived from colostrum and milk that has been found to possess various immunomodulatory, iron chelating, and antimicrobial properties, especially in its apo-form. Recent studies have demonstrated the functionality of LF in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d499158aa3568ad1aef1c8975a1bcc95
https://doi.org/10.1080/07391102.2022.2121759
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8
Akademický článek
Systems approach to the pharmacological actions of HDAC inhibitors reveals EP300 activities and convergent mechanisms of regulation in diabetes
Autor: Haloom Rafehi, Antony Kaspi, Mark Ziemann, Jun Okabe, Tom C. Karagiannis, Assam El-Osta
Publikováno v: Epigenetics, Vol 12, Iss 11, Pp 991-1003 (2017)
Given the skyrocketing costs to develop new drugs, repositioning of approved drugs, such as histone deacetylase (HDAC) inhibitors, may be a promising strategy to develop novel therapies. However, a gap exists in the understanding and advancement of t
Externí odkaz: https://doaj.org/article/5134259e194f440cb27c30eff0d0e99c
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