Zobrazeno 1 - 10
of 337
pro vyhledávání: '"C. K. Chiu"'
Autor:
Susan A. Charman, Alice Andreu, Helena Barker, Scott Blundell, Anna Campbell, Michael Campbell, Gong Chen, Francis C. K. Chiu, Elly Crighton, Kasiram Katneni, Julia Morizzi, Rahul Patil, Thao Pham, Eileen Ryan, Jessica Saunders, David M. Shackleford, Karen L. White, Lisa Almond, Maurice Dickins, Dennis A. Smith, Joerg J. Moehrle, Jeremy N. Burrows, Nada Abla
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-27 (2020)
Abstract Background Modelling and simulation are being increasingly utilized to support the discovery and development of new anti-malarial drugs. These approaches require reliable in vitro data for physicochemical properties, permeability, binding, i
Externí odkaz:
https://doaj.org/article/e55944d6ff034a1fadacb975357d1421
Autor:
Yuxiang Dong, Yogesh Sonawane, Steven P. Maher, Anne-Marie Zeeman, Victor Chaumeau, Amélie Vantaux, Caitlin A. Cooper, Francis C. K. Chiu, Eileen Ryan, Jenna McLaren, Gong Chen, Sergio Wittlin, Benoît Witkowski, François Nosten, Kamaraj Sriraghavan, Dennis E. Kyle, Clemens H. M. Kocken, Susan A. Charman, Jonathan L. Vennerstrom
Publikováno v:
ACS Omega. 7:12401-12411
The catechol derivative RC-12 (WR 27653) (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e050e54dd84232f0b99386c14fc1b10a
https://doi.org/10.1021/acsomega.2c01099
https://doi.org/10.1021/acsomega.2c01099
Autor:
Atsuko Ochida, Masahiro Kamaura, Angelika Sturm, Xue Chen, Karen L. White, Benoît Laleu, Binglin Wang, Benigno Crespo, Yuichiro Akao, Nobuo Cho, Gong Chen, Vicky M. Avery, Sergio Wittlin, Laura M. Sanz, Francis C. K. Chiu, Koen J. Dechering, David M. Shackleford, Kasiram Katneni, Sandra Duffy, Leonardo Lucantoni, Susan A. Charman
Publikováno v:
Journal of Medicinal Chemistry. 64:12582-12602
A phenotypic high-throughput screen allowed discovery of quinazolinone-2-carboxamide derivatives as a novel antimalarial scaffold. Structure-activity relationship studies led to identification of a potent inhibitor 19f, 95-fold more potent than the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2cf33a3e0cc4d27cbcc8fe60cf19f5e
https://doi.org/10.1021/acs.jmedchem.1c00441
https://doi.org/10.1021/acs.jmedchem.1c00441
Publikováno v:
Journal of Business Ethics. 180:57-69
Creativity and morality are key attributes that stakeholders demand of organizations. Accordingly, higher education institutions and professional training programs also seek to cultivate these attributes in future leaders. However, research has hithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b91d4aa94728fb9b165ebb17f2ad681
https://doi.org/10.1007/s10551-021-04876-3
https://doi.org/10.1007/s10551-021-04876-3
Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
Autor:
Nada Abla, Yuxiang Dong, Daniel Hunziker, Jörg J. Möhrle, André Alker, Jenna McLaren, Hugues Matile, Jonathan L. Vennerstrom, Kasiram Katneni, Christian Scheurer, Susan A. Charman, Sriraghavan Kamaraj, Scott Blundell, Xiaofang Wang, Sergio Wittlin, Lin Zhou, Francis C. K. Chiu, David M. Shackleford, Qingjie Zhao
Publikováno v:
ACS Infect Dis
OZ439 is a potent synthetic ozonide evaluated for the treatment of uncomplicated malaria. The metabolite profile of OZ439 was characterized in vitro using human liver microsomes combined with LC/MS-MS, chemical derivatization, and metabolite synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3be4a450af4d05a8bd5e3a45a546d15
https://doi.org/10.1021/acsinfecdis.1c00225
https://doi.org/10.1021/acsinfecdis.1c00225
Akademický článek
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Akademický článek
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Akademický článek
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Publikováno v:
Asia Pacific Journal of Human Resources. 60:658-681
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d66d9c368799b955c8073607c56d4341
https://doi.org/10.1111/1744-7941.12292
https://doi.org/10.1111/1744-7941.12292
Autor:
Pradipsinh K. Rathod, Margaret A. Phillips, Michael J. Palmer, Sreekanth Kokkonda, Farah El Mazouni, John H. White, David Waterson, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Maria Santos Martinez-Martinez, Helena Barker, Leticia Huertas-Valentin, Jenna McLaren, Santiago Ferrer, Jeremy N. Burrows, Shatrughan P Shahi, Karen L. White, Maria Jose Lafuente-Monasterio, Dave Matthews, Gong Chen, Francis C. K. Chiu, David M. Shackleford, Elly Crighton, Kasiram Katneni, Xiaoyi Deng, Sergio Wittlin, Diana R. Tomchick, Susan A. Charman, Rajesh Chittimalla
Publikováno v:
J Med Chem
Malaria puts at risk nearly half the world's population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is a validated target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c8bca2acecd67955624d5564e79816
https://doi.org/10.1021/acs.jmedchem.0c00311
https://doi.org/10.1021/acs.jmedchem.0c00311