Výsledky vyhledávání - "C. Jozefczak"

Pharmacokinetic characteristics of bornaprolol in healthy volunteers

Autor: C Jozefczak, V. Lecoq, B. Lecoq, P. Jaillon, A. Cheymol, G. Cheymol

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 20(8)

1. Six young male volunteers received five single doses of bornaprolol, i.v. (20 mg) and orally (120, 240, 480, 960 mg) administered at 2-week intervals. Plasma concentrations of bornaprolol and its conjugated metabolite were determined by gas chroma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb944475829692b5f77af3628122d84
https://pubmed.ncbi.nlm.nih.gov/1977241

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A subacute treatment of L-methionine induces an increase in the number of [3H]spiperone binding sites in the striatum of the rat

Autor: F. Marquis, G. Le Fur, T. Phan, Andre Uzan, Marie-Claude Burgevin, A. Flamier, N. Mitrani, C. Jozefczak

Publikováno v: Life Sciences. 32:2321-2328

A subacute treatment, 500 mg/kg I.P. twice daily during 5 days, by L-methionine provoked an increase in the Bmax of [3H]-spiperone binding in the striatum of the rat. This increase was associated to a decrease in membrane microviscosity. However in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0d08da6cb1accbaeb0355829251e63
https://doi.org/10.1016/0024-3205(83)90761-0

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Sensitive gas chromatographic method for the determination in plasma of FM 24, 1-(2-exo-bicyclo[2,2,1]hept-2-ylphenoxy)-3[(1-methylethyl)amino]-2-propanol, a new beta-adrenoceptor blocking agent

Autor: C. Jozefczak, N. Ferry, M. Seccia, Jean Sassard, G. Cuisinaud, N. Bernard

Publikováno v: Journal of chromatography. 183(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc854036c2c314b887bfaf72e94ffb6f
https://pubmed.ncbi.nlm.nih.gov/6105161

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Pharmacokinetics and effects on exercise heart rate of PK 11195 (52028 RP), an antagonist of peripheral benzodiazepine receptors, in healthy volunteers

Autor: A. Ferry, C. Jozefczak, Patrice Jaillon, V. Lecocq, B. Lecocq

Publikováno v: Fundamentalclinical pharmacology. 3(4)

PK 11195 (or 52028 RP; 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinoline carboxamide), an antagonist of the peripheral-type benzodiazepine receptors which are coupled to calcium channels, was administered to 10 healthy volunteers in order

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f32ac12e12ec0c3daa3ab385cc1b53e2
https://pubmed.ncbi.nlm.nih.gov/2553568

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PK 10139 and quinidine: interactions with digoxin concentrations in rats and dogs

Autor: C. Jozefczak, Andre Uzan, G. Le Fur, Caroline Rougeot, M. Mestre

Publikováno v: The Journal of pharmacy and pharmacology. 36(5)

Quinidine induced an increase in digoxin plasma concentrations in rats and dogs. PK 10139, an antiarrhythmic agent 10 times more potent than quinidine, did not change digoxin plasma concentrations in these species. The results indicate that PK 10139

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1778f628ca23e18725bfcb9c0806f3a6
https://pubmed.ncbi.nlm.nih.gov/6145779

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On the long acting gastric antisecretory activity of LM 24056 a non H2 antagonist

Autor: G. Le Fur, C. Jozefczak, Andre Uzan, J. Rataud, J. Mizoule, D. Quarteronet

Publikováno v: Life sciences. 31(14)

LM 24056, a phenothiazine derivative with no central effects, can be classified as a non anti H 2 antisecretory agent with a long duration of action. Its activity was demonstrated orally at low dose in pentagastrin stimulated Shay rat and in Heidenha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977848666df81873f31daf714018b132
https://pubmed.ncbi.nlm.nih.gov/7144436

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High-performance liquid chromatographic determination of indalpine, a new non-tricyclic antidepressant, in human plasma: identification and simultaneous measurement of its major plasma metabolite

Autor: C, Jozefczak, N, Ktorza, A, Uzan

Publikováno v: Journal of chromatography. 230(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::75eece41cb2bc8044b6a6fa63c2acc6a
https://pubmed.ncbi.nlm.nih.gov/7107771

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Comparative cardiac electrophysiologic study of PK 10139, a new antiarrhythmic agent, and quinidine in anesthetized dogs: plasma concentration-response relationships

Autor: Heckle J, Georges Cheymol, Patrice Jaillon, C Jozefczak

Publikováno v: Journal of cardiovascular pharmacology. 7(1)

Cardiac electrophysiologic effects of PK 10139 (PK), a new quinoleic antiarrhythmic agent, were compared with those of quinidine sulphate (Q) after three cumulative intravenous doses of 0.75, 1.5, and 3 mg/kg of PK and 5, 10, and 20 mg/kg of Q in ane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afc08863f111e841b329b4f64c1f4b4
https://pubmed.ncbi.nlm.nih.gov/2580140

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