Zobrazeno 1 - 10
of 38
pro vyhledávání: '"C. John Harris"'
Autor:
Christophe, Fromont, Alessio, Atzori, Divneet, Kaur, Lubna, Hashmi, Graziella, Greco, Alejandro, Cabanillas, Huy Van, Nguyen, D Heulyn, Jones, Miguel, Garzón, Ana, Varela, Brett, Stevenson, Greg P, Iacobini, Marc, Lenoir, Sundaresan, Rajesh, Clare, Box, Jitendra, Kumar, Paige, Grant, Vera, Novitskaya, Juliet, Morgan, Fiona J, Sorrell, Clara, Redondo, Andreas, Kramer, C John, Harris, Brendan, Leighton, Steven P, Vickers, Sharon C, Cheetham, Colin, Kenyon, Anna M, Grabowska, Michael, Overduin, Fedor, Berditchevski, Chris J, Weston, Stefan, Knapp, Peter M, Fischer, Sam, Butterworth
Publikováno v:
Journal of Medicinal Chemistry
Polymorphisms in the region of the calmodulin-dependent kinase isoform D (CaMK1D) gene are associated with increased incidence of diabetes, with the most common polymorphism resulting in increased recognition by transcription factors and increased pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d6c85da3950756a5738a215048fb4a89
https://pubmed.ncbi.nlm.nih.gov/32433887
https://pubmed.ncbi.nlm.nih.gov/32433887
Autor:
Fedor Berditchevski, Lubna Hashmi, Stevenson Brett W, Graziella Greco, Juliet Morgan, Alessio Atzori, Sundaresan Rajesh, Anna M. Grabowska, Divneet Kaur, Ana Varela, Alejandro Cabanillas, Huy V. Nguyen, Marc Lenoir, Sharon C. Cheetham, Greg P. Iacobini, Colin Kenyon, Christopher J. Weston, Christophe Fromont, Clare L. Box, Miguel Garzon, Brendan Leighton, D. Heulyn Jones, Jitendra Kumar, Fiona J. Sorrell, Steven P. Vickers, Sam Butterworth, C. John Harris, Paige Grant, Clara Redondo, Peter Fischer, Michael Overduin, Andreas Krämer, Vera Novitskaya, Stefan Knapp
Publikováno v:
Butterworth, S & Garzon Sanz, M 2020, ' Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model ', Journal of Medicinal Chemistry, vol. 63, no. 13, pp. 6784-6801 . https://doi.org/10.1021/acs.jmedchem.9b01803
Journal of medicinal chemistry 63(13), 6784-6801 (2020). doi:10.1021/acs.jmedchem.9b01803
Journal of medicinal chemistry 63(13), 6784-6801 (2020). doi:10.1021/acs.jmedchem.9b01803
Polymorphisms in the region of the calmodulin-dependent kinase isoform D (CaMK1D) gene are associated with increased incidence of diabetes, with the most common polymorphism resulting in increased recognition by transcription factors and increased pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5530ea1a6282165c274343b752573f14
https://doi.org/10.1021/acs.jmedchem.9b01803
https://doi.org/10.1021/acs.jmedchem.9b01803
Autor:
Digby F. Warner, Krupa Naran, Nina Lawrence, Helena I. Boshoff, Renier van der Westhuyzen, Atica Moosa, Richard Gordon, Clifton E. Barry, Kelly Chibale, Tzu-Shean Feng, Leslie J. Street, C. John Harris, Garreth L. Morgans, Richard K. Gessner, Candice Soares de Melo
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:7240-7250
Whole-cell high-throughput screening of a diverse SoftFocus library against Mycobacterium tuberculosis (Mtb) generated a novel aminopyrazolo[1,5-a]pyrimidine hit series. The synthesis and structure activity relationship studies identified compounds w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8372228b3c3dbaf92403357dab7b1b
https://doi.org/10.1016/j.bmc.2015.10.021
https://doi.org/10.1016/j.bmc.2015.10.021
Publikováno v:
Current Pharmaceutical Design. 20:3314-3322
Compilation of an appropriate set of compounds is essential for the success of a small molecule screen. When very little is known about the target and when no or few ligands have been identified, the screening file is often made as diverse as possibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ebf8b62b43539f6d50991925faf99b
https://doi.org/10.2174/13816128113199990602
https://doi.org/10.2174/13816128113199990602
With a focus on case studies of R&D programs in a variety of disease areas, the book highlights fundamental productivity issues the pharmaceutical industry has been facing and explores potential ways of improving research effectiveness and efficiency
Autor:
Kenichiro Kataoka, Hiroaki Makino, Keiichiro Imaizumi, Brad Sherborne, Gen Unoki, Donald James Simpson, Naotaka Suzuki, C. John Harris, Richard K. Gordon, Tomomi Kosugi, Vicky Cunliffe, Heidi Kalloo-Hosein, Dale Robert Mitchell, Peter S Thomas, Kanji Komatsu, Midori Takimoto-Kamimura, Sugiura Satoshi, Mika Kambe, Yuri Sakai, Shinji Kobayashi, Aiko Fujino, Gita Patel, Yuko Yamakoshi, Julie A. Frearson, Oue Yasuhiro, Takenouchi Osami, Imai Minoru, Joelle Le, Yohei Matsueda
Publikováno v:
Journal of Medicinal Chemistry. 55:6700-6715
A novel class of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) inhibitors was discovered through screening a kinase-focused library. A homology model of MAPKAP-K2 was generated and used to guide the initial SAR studies and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0728626099c0f201fdffc260a93476
https://doi.org/10.1021/jm300411k
https://doi.org/10.1021/jm300411k
Autor:
Adrian P. Stevens, C. John Harris
Publikováno v:
Drug Discovery Today. 11:880-888
In the post-genomic era, if all proteins in a gene family can putatively be identified, how can drug discovery effectively tackle so many novel targets that might lack structural and small-molecule inhibitory data? In response, chemogenomics, a new a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ccb60d0955b26340ecfb953f054fc93
https://doi.org/10.1016/j.drudis.2006.08.013
https://doi.org/10.1016/j.drudis.2006.08.013
Autor:
J. Richard Morphy, C John Harris
Multi-target drug discovery (MTDD) is an emerging area of increasing interest to the drug discovery community. Drugs that modulate several targets have the potential for an improved balance of efficacy and safety compared to single targets agents. Al
Autor:
C John Harris, Paul M. Doyle, Peter J. Sadler, Julia Uppenbrink, Laurence H. Pearl, Janet M. Thornton, Claire M. Moody, David T. Jones, John H. Viles
Publikováno v:
Proteins: Structure, Function, and Genetics. 24:502-513
In response to the Paracelsus Challenge (Rose and Creamer, Proteins, 19:1-3, 1994), we present here the design, synthesis, and characterization of a helical protein, whose sequence is 50% identical to that of an all-beta protein. The new sequence was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73de1aca06e495cbe28d9a2cef12629b
https://doi.org/10.1002/(sici)1097-0134(199604)24:4<502::aid-prot9>3.0.co
https://doi.org/10.1002/(sici)1097-0134(199604)24:4<502::aid-prot9>3.0.co
Autor:
Ray Stepney, Paul Leff, M.L. Bolofo, Alan McNeill, Paul Barraclough, C. John Harris, Alan D. Robertson, Janet M. Gillam, Brendan J. R. Whittle, Heather Giles, Michael G. Kelly
Publikováno v:
Bioorganic & Medicinal Chemistry. 4:81-90
The rationale for investigating conformationally restricted analogues of BW245C as DP-receptor ligands and the syntheses of three such racemic bicyclic imidazolidinone analogues are described. Compounds 7 (BW587C), 8 (BW480C85), and 9 (BW572C85) were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96594a9666673275121ccee2d38cd9b
https://doi.org/10.1016/0968-0896(95)00173-5
https://doi.org/10.1016/0968-0896(95)00173-5