Zobrazeno 1 - 10
of 23
pro vyhledávání: '"C. Jeffery Woodbury"'
Autor:
Kristen M Smith-Edwards, Jennifer J DeBerry, Jami L Saloman, Brian M Davis, C Jeffery Woodbury
Publikováno v:
eLife, Vol 5 (2016)
Inflammatory pain is thought to arise from increased transmission from nociceptors and recruitment of 'silent' afferents. To evaluate inflammation-induced changes, mice expressing GCaMP3 in cutaneous sensory neurons were generated and neuronal respon
Externí odkaz:
https://doaj.org/article/4b55ca16e1d54cf38e9dedf1febd04a9
Autor:
Colleen Cassidy, Brendan P. Lehnert, Ling Bai, Travis L. Dickendesher, Junwei Liu, Pann H. Nwe, Nicole Neubarth, C. Jeffery Woodbury, David D. Ginty
Publikováno v:
Cell. 163:1783-1795
Touch perception begins with activation of low-threshold mechanoreceptors (LTMRs) in the periphery. LTMR terminals exhibit tremendous morphological heterogeneity that specifies their mechanical receptivity. In a survey of mammalian skin, we found a p
Autor:
C. Jeffery Woodbury, Lishi Li, Nathaniel Heintz, Michael Rutlin, Laura Kus, Colleen Cassidy, Shiaoching Gong, Victoria E. Abraira, David D. Ginty, Wenqin Luo, Michael P. Jankowski, H. Richard Koerber
Publikováno v:
Cell. 147(7):1615-1627
SummaryInnocuous touch of the skin is detected by distinct populations of neurons, the low-threshold mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ-, and C-LTMRs. Here, we report genetic labeling of LTMR subtypes and visualization of the
Autor:
C. Jeffery Woodbury, Yi Ye
Publikováno v:
Journal of Neurophysiology. 103:1385-1396
Cutaneous myelinated nociceptors are known to exhibit considerable heterogeneity in their response to noxious heat. In the present experiments, we studied heat sensitivity among myelinated nociceptors during early postnatal life to determine whether
Autor:
Yabo Guan, Xingmei Wang, Robert H. Edwards, Srinivasa N. Raja, Allan I. Basbaum, C. Jeffery Woodbury, Rebecca P. Seal
Publikováno v:
Nature
Mechanical pain contributes to the morbidity associated with inflammation and trauma, but primary sensory neurons that convey the sensation of acute and persistent mechanical pain have not been identified. Dorsal root ganglion (DRG) neurons transmit
Autor:
Brian M. Davis, H. Richard Koerber, Sabrina L. McIlwrath, Jeffrey J. Lawson, C. Jeffery Woodbury
Publikováno v:
The Journal of Pain. 9:298-308
In the present study, a murine ex vivo somatosensory system preparation was used to determine the response characteristics of cutaneous sensory neurons staining positively for TRPV1 or TRPV2. TRPV1 immunostaining was found exclusively (11/11) in a sp
Publikováno v:
The Journal of Comparative Neurology. 508:500-509
It is widely thought that, after peripheral injury, some low-threshold mechanoreceptive (LTMR) afferents "sprout" into pain-specific laminae (I-II) of the dorsal horn and are responsible for chronic pain states such as mechanical allodynia. Although
Autor:
Brian M. Davis, Kathryn M. Albers, H. Richard Koerber, Michael J. Caterina, Martin Koltzenburg, Melissa Zwick, C. Jeffery Woodbury, Jeffrey J. Lawson, Shuying Wang
Publikováno v:
The Journal of Neuroscience. 24:6410-6415
Vanilloid receptor 1 (TRPV1) has been proposed to be the principal heat-responsive channel for nociceptive neurons. The skin of both rat and mouse receives major projections from primary sensory afferents that bind the plant lectin isolectin B4 (IB4)
Publikováno v:
The Journal of Comparative Neurology. 471:352-360
To determine the role of NT3 in the postnatal maturation of Merkel cell (MC) sensory neurite complexes (touch domes), we examined the development of their neural and end-organ components in wild-type and transgenic mice that overexpress NT3 (NT3-OE).