Zobrazeno 1 - 10
of 21
pro vyhledávání: '"C. Jane Dale"'
Publikováno v:
Virology. 337:222-234
Although T cell immunity is important in the control of HIV-1 infection, the characteristics of effective HIV-specific T cell responses are unclear. We previously observed protection from virulent SHIV challenges in macaques administered priming with
Publikováno v:
Trends in Microbiology. 13:243-246
Many viruses that cause chronic viremic infections, such as human immunodeficiency virus type 1 (HIV-1), mutate extensively to avoid effective control by the host immune system. However, each immune escape mutation probably results in some fitness co
Autor:
C. Jane Dale, C. Jill Medveczky, Diah Iskandriati, Robert De Rose, Stephen J. Kent, Scott Thomson, Joko Pamungkas, Ian A. Ramshaw, Maryanne Shoobridge, Rachmitasari Noviana, Yasmina Paramastri
Publikováno v:
AIDS Research and Human Retroviruses. 21:292-300
T cell immunity plays a critical role in controlling HIV-1 viremia, and encoding a limited set of HIV-1 genes within DNA and poxvirus vectors can, when used sequentially, induce high levels of T cell immunity in primates. However, a limited breadth o
Autor:
Kim Wilson, Scott Thomson, Socheata Chea, Jeanettea Reece, David B. Boyle, Barbara E.H. Coupar, Robert De Rose, Stephen J. Kent, Mark T. Sullivan, Caroline S. Fernandez, Ian A. Ramshaw, C. Jane Dale
Publikováno v:
Vaccine. 23:1949-1956
To induce broad T cell immunity to HIV-1, we evaluated the safety, immunogenicity and dose-response relationship of DNA and recombinant Fowlpoxvirus (rFPV) vaccines encoding five shared HIV subtype AE genes (Gag, Pol, Env, Tat, Rev) in pigtail macaqu
Publikováno v:
Journal of Medical Primatology. 29:240-247
Preventive and:or therapeutic vaccines against Human Im- munodeficiency Virus (HIV-1) are urgently required. Induction of cellu- lar immunity is favoured since these responses correlate with control of HIV-1. Recombinant fowlpoxvirus (FPV) vaccines e
Publikováno v:
AIDS Research and Human Retroviruses. 18:227-230
Proviral SIV DNA inoculation of macaques is an efficient method to initiate wild-type and attenuated SIV infections. However, we found that macaques inoculated with SIV DNA engineered to contain a single 105-bp deletion in the 3' nef/LTR overlap regi
Autor:
C. Jane Dale, Stephen J. Kent
Publikováno v:
Expert Opinion on Therapeutic Patents. 10:1179-1188
A preventive vaccine for HIV is urgently needed to curb the AIDS pandemic. Research and development of HIV vaccines is accelerating and there is increasing evidence that a viable market will be identified. The basic approaches to HIV vaccine design (
Publikováno v:
Drugs in R & D. 1:431-440
The global human immunodeficiency virus type 1 (HIV-1) epidemic is devastating many communities and a well tolerated and effective vaccine is urgently required. Several lines of evident suggest that vaccine-induced protective immunity can be achieved
Autor:
Robert De Rose, Stephen J. Kent, Mark T. Sullivan, Sean Emery, Ian A. Ramshaw, C. Jane Dale, David A. Cooper, David B. Boyle, Anthony D. Kelleher
Publikováno v:
Human Vaccines. 2:134-136
Estimating effective doses of novel HIV vaccines is challenging. Dose-response analyses of DNA and fowlpox virus HIV vaccines showed that 1 mg of DNA vaccine and 5 x 10(7)pfu of fowlpox virus booster was immunogenic in macaques. However, this dose wa
Publikováno v:
Medical Journal of Australia. 177:587-589