Výsledky vyhledávání - "C. J. Simeonovic"

Akademický článek

Pancreatic Islet Basement Membrane Loss and Remodeling after Mouse Islet Isolation and Transplantation: Impact for Allograft Rejection

Autor: H. F. Irving-Rodgers, F. J. Choong, K. Hummitzsch, C. R. Parish, R. J. Rodgers, C. J. Simeonovic

Publikováno v: Cell Transplantation, Vol 23 (2014)

The isolation of islets by collagenase digestion can cause damage and impact the efficiency of islet engraftment and function. In this study, we assessed the basement membranes (BMs) of mouse pancreatic islets as a molecular biomarker for islet integ

Externí odkaz: https://doaj.org/article/bf58600c082f4db8998e9af242413af5

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Immune mechanisms associated with the rejection of fetal murine proislet allografts and pig proislet xenografts: comparison of intragraft cytokine mRNA profiles

Autor: C J, Simeonovic, M J, Townsend, C F, Morris, A J, Hapel, M C, Fung, D A, Mann, I G, Young, J D, Wilson

Publikováno v: Transplantation. 67(7)

Previous in vivo depletion studies of CD4 and CD8 T cells indicated that different rejection mechanisms operate for proislet allografts and xenografts. The cellular and molecular mechanisms of acute proislet allograft and xenograft rejection have the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff6fdc42319bc3531965b185420cdebe
https://pubmed.ncbi.nlm.nih.gov/10221479

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Pancreatic Islet and Proislet Transplantation in the Mouse Model

Autor: J. C. Zarb, L. S. Gazda, C. J. Simeonovic, K. J. Lafferty, J. D. Wilson

Publikováno v: Organtransplantation in Rats and Mice ISBN: 9783642721427

Islets of Langerhans are units of specialized endocrine tissue scattered throughout the pancreas of mature or adult individuals; each “islet” is composed mainly of insulin-producing β cells as well as glucagon-secreting α cells and δ cells whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a80e7d830e53480eaaf98ba15ee72b95
https://doi.org/10.1007/978-3-642-72140-3_21

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Eosinophils are not required for the rejection of neovascularized fetal pig proislet xenografts in mice

Autor: C J, Simeonovic, M J, Townsend, J D, Wilson, K U, McKenzie, A J, Ramsay, K I, Matthaei, D A, Mann, I G, Young

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 158(5)

The rejection of neovascularized pig proislet (islet precursor) xenografts in mice is a CD4 T cell-dependent process involving invasion of the graft site mainly by host CD4 T cells and eosinophils. We previously identified CD4 T cell-dependent enhanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::28dca35e467267c90276249633b6dea9
https://pubmed.ncbi.nlm.nih.gov/9037001

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Intragraft expression of cytokine transcripts during pig proislet xenograft rejection and tolerance in mice

Autor: C F, Morris, C J, Simeonovic, M C, Fung, J D, Wilson, A J, Hapel

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 154(5)

The rejection of pig proislet (islet precursor) xenografts in CBA/H mice is a CD4+ T cell-dependent process. The molecular mechanisms of xenograft rejection, xenograft survival during anti-CD4 mAb therapy and xenograft tolerance post-withdrawal of an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4561f46c20959a9ea66af5bbe8ee2b6f
https://pubmed.ncbi.nlm.nih.gov/7868913

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