Zobrazeno 1 - 4
of 4
pro vyhledávání: '"C. J. R. Hedgecock"'
Publikováno v:
Tetrahedron Letters. 33:547-550
A versatile route for the preparation of 2-ketomethylene phospholipids using dithiane chemistry is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d3a85f33a03f15795698a0272bc76d8
https://doi.org/10.1016/s0040-4039(00)93992-3
https://doi.org/10.1016/s0040-4039(00)93992-3
Autor:
C. B. Jones, E. A. Kuo, Yea Christopher Martyn, C. J. R. Hedgecock, Peter W. Hairsine, N. Mcdowall, R. A. Williamson, P. Hambleton, W. R. Tully, Robert Westwood, Saroop S. Matharu, Ian R. Ager, David Kay, A. W. E. Chan, P. L. Evans, E. Little
Publikováno v:
Journal of medicinal chemistry. 39(23)
The active metabolite (2) of the novel immunosuppressive agent leflunomide (1) has been shown to inhibit the enzyme dihydroorotate dehydrogenase (DHODH). This enzyme catalyzes the fourth step in de novo pyrimidine biosynthesis. A series of analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8746ffa16b541e863c47865210f535c
https://pubmed.ncbi.nlm.nih.gov/8917650
https://pubmed.ncbi.nlm.nih.gov/8917650
Publikováno v:
Chemischer Informationsdienst. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e22220680a58896a66873eecb6021b7
https://doi.org/10.1002/chin.197920348
https://doi.org/10.1002/chin.197920348
Autor:
D. H. G. CROUT, C. J. R. HEDGECOCK
Publikováno v:
Chemischer Informationsdienst. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::814235b66f60aa5fbb7ebed0545de27a
https://doi.org/10.1002/chin.197950112
https://doi.org/10.1002/chin.197950112