Výsledky vyhledávání - "C. J. Ohnmacht"

Behavioral approach to nondyskinetic dopamine antagonists: identification of seroquel

Autor: E J, Warawa, B M, Migler, C J, Ohnmacht, A L, Needles, G C, Gatos, F M, McLaren, C L, Nelson, K M, Kirkland

Publikováno v: Journal of medicinal chemistry. 44(3)

A great need exists for antipsychotic drugs which will not induce extrapyramidal symptoms (EPS) and tardive dyskinesias (TDs). These side effects are deemed to be a consequence of nonselective blockade of nigrostriatal and mesolimbic dopamine D2 rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0ad655f8c4f1920b8755c7e22be7eb93
https://pubmed.ncbi.nlm.nih.gov/11462978

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Studies of the K(ATP) channel opening activity of the new dihydropyridine compound 9-(3-cyanophenyl)-3,4,6,7,9,10-hexahydro-1,8-(2H,5H)-acridined ione in bladder detrusor in vitro

Autor: J H, Li, G D, Yasay, S T, Kau, C J, Ohnmacht, D A, Trainor, A D, Bonev, T J, Heppner, M T, Nelson

Publikováno v: Arzneimittel-Forschung. 46(5)

The potassium (K+) channel opening activity of ZM244085 (9-(3-cyanophenyl)-3,4,6,7,9,10-hexahydro-1,8-(2H,5H)-acridined ione, CAS 149398-59-4), a novel dihydropyridine (DHP), was ascertained. In a set of functional assays, its mechanoinhibitory effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a4eed64517e1a8186c2a6136696f6b14
https://pubmed.ncbi.nlm.nih.gov/8737640

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ZENECA ZD6169: a novel KATP channel opener with in vivo selectivity for urinary bladder

Autor: B B, Howe, T J, Halterman, C L, Yochim, M L, Do, S J, Pettinger, R B, Stow, C J, Ohnmacht, K, Russell, J R, Empfield, D A, Trainor

Publikováno v: The Journal of pharmacology and experimental therapeutics. 274(2)

(S)-N-(4-benzoylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methyl-propionamide (ZD6169) is a novel ATP-sensitive potassium channel opener. Bladder activity and selectivity after oral dosing were studied in conscious, normotensive rats and dogs by monitoring

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::43bc0d007213df489f9d3c04bfb54531
https://pubmed.ncbi.nlm.nih.gov/7636752

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K-channel opening activity of ZD6169 and its analogs: effect on 86Rb efflux and 3H-P1075 binding in bladder smooth muscle

Autor: S, Trivedi, S L, Stetz, L, Potter-Lee, M, McConville, J H, Li, J, Empfield, C J, Ohnmacht, K, Russell, F J, Brown, D A, Trainor

Publikováno v: Pharmacology. 50(6)

Zeneca ZD6169, (S)-N-(4-benzoylphenyl)-3,3,3-trifluoro- 2-hydroxy-2-methylpropionamide, is a novel compound which relaxes urinary bladder smooth muscle in vitro. The effect of ZD6169 and two of its analogs on 86Rb efflux and 3H-P1075 binding in guine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3132bb27d0fb3bf843e9115c08b281db
https://pubmed.ncbi.nlm.nih.gov/7568338

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K-channel opening activity of dihydropyridine ZM244085: effect on 86Rb efflux and 3H-P1075 binding in urinary bladder smooth muscle

Autor: S, Trivedi, L, Potter-Lee, M W, McConville, J H, Li, C J, Ohnmacht, D A, Trainor, S T, Kau

Publikováno v: Research communications in molecular pathology and pharmacology. 88(2)

Zeneca ZM244085, 9-(3 cyanophenyl)hexahydro-1,8 acridinedione, is a novel dihydropyridine (DHP) which relaxes KCl precontracted urinary bladder smooth muscle in vitro. The effect of ZM244085 on low and high KCl induced contractions, 86Rb efflux and [

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::54339b4ba69b672001881a5e5b3a478b
https://pubmed.ncbi.nlm.nih.gov/7670846

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Studies of the KATP Channel Opening Activity of the New Dihydropyridine Compound 9-(3-Cyanophenyl)-3,4,6,7,9,10-Hexahydro-1,8-(2H, 5H)-Acridinedione in Bladder Detrusor In Vitro

Autor: J. H. Li, G. D. Yasay, S. T. Kau, C. J. Ohnmacht, D. A. Trainor, A. D. Bonev, T. J. Heppner, M. T. Nelson

Publikováno v: The Journal of Urology. :2264

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4405053c6a81717d9f7e30b0cf7fb337
https://doi.org/10.1097/00005392-199806000-00212

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Antimalarials. 10. Substituted 3-halo- and 3-methoxy-2-aryl-4-quinoline(dibutylaminomethyl)methanols

Autor: J. M. Sanders, Munson Hr, C. J. Ohnmacht, R. E. Johnson, R. E. Lutz

Publikováno v: Journal of Medicinal Chemistry. 18:1232-1236

Four 2-aryl-4-quinoline(di-n-butylaminomethyl)methanols with Br, Cl, F, or OMe in position 3 were synthesized by modifications of standard reactions. The antimalarial activity decreased with increased size of the 3-substituent. The 3-F-4',6,8-Cl3 com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8611e988f46a0677958ede0b0e268d
https://doi.org/10.1021/jm00246a012

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