Výsledky vyhledávání - "C. J. M. Van Noesel"

Akademický článek

Presence of a 34-gene signature is a favorable prognostic marker in squamous non-small cell lung carcinoma

Autor: W. S. M. E. Theelen, O. Krijgsman, K. Monkhorst, T. Kuilman, D. D. G. C. Peters, S. Cornelissen, M. A. Ligtenberg, S. M. Willems, J. L. G. Blaauwgeers, C. J. M. van Noesel, D. S. Peeper, M. M. van den Heuvel, K. Schulze

Publikováno v: Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-12 (2020)

Abstract Background The tumor immune microenvironment is a heterogeneous entity. Gene expression analysis allows us to perform comprehensive immunoprofiling and may assist in dissecting the different components of the immune infiltrate. As gene expre

Externí odkaz: https://doaj.org/article/debbea0e0b5047e685a2c5ef50af7bd0

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De novo gene mutations in normal human memory B cells

Autor: Jeroen E. J. Guikema, Koen Wagner, M. J. Kwakkenbos, Aldo Jongejan, C. J. M. Van Noesel, Richard J. Bende, Thera A. M. Wormhoudt, A. C. M. van Kampen, Linda M. Slot, Aranka V Ballering

Publikováno v: Leukemia, 33(5), 1219-1230. Nature Publishing Group

In the past years, the genomes of thousands of tumors have been elucidated. To date however, our knowledge on somatic gene alterations in normal cells is very limited. In this study, we demonstrate that tetanus-specific human memory B lymphocytes car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0642b71017d3463a53b8f53732e29cc6
https://doi.org/10.1038/s41375-018-0289-4

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Presence of a 34-gene signature is a favorable prognostic marker in squamous non-small cell lung carcinoma

Autor: Thomas Kuilman, Oscar Krijgsman, Daniel S. Peeper, M. van den Heuvel, Dennis Peters, Katja Schulze, Maarten A. Ligtenberg, Sten Cornelissen, Kim Monkhorst, Willemijn S. M. E. Theelen, Stefan M. Willems, J. L. G. Blaauwgeers, C. J. M. van Noesel

Publikováno v: Journal of Translational Medicine
Journal of Translational Medicine, 18, 1
Journal of Translational Medicine, 18
Journal of translational medicine, 18(1):271. BioMed Central Ltd.
Journal of translational medicine, 18(1):271. BioMed Central
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-12 (2020)

Background The tumor immune microenvironment is a heterogeneous entity. Gene expression analysis allows us to perform comprehensive immunoprofiling and may assist in dissecting the different components of the immune infiltrate. As gene expression ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120110cf5385d2e420e102c593dd0c2f
https://pubmed.ncbi.nlm.nih.gov/32620126

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Additional file 2 of Presence of a 34-gene signature is a favorable prognostic marker in squamous non-small cell lung carcinoma

Autor: Theelen, W. S. M. E., O. Krijgsman, K. Monkhorst, T. Kuilman, D. D. G. C. Peters, S. Cornelissen, M. A. Ligtenberg, S. M. Willems, J. L. G. Blaauwgeers, C. J. M. Van Noesel, D. S. Peeper, M. M. Van Den Heuvel, K. Schulze

Additional file 2: Figure S1. A) Flowchart of samples for NanoString analysis. B) QC data NanoString: positive/negative controls and keratin expression. C) The 34-gene signature does not work on TCGA RNA-seq data: unmeasurable or low expression of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fc61c83c177e00f4611c106b59819b

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Additional file 4 of Presence of a 34-gene signature is a favorable prognostic marker in squamous non-small cell lung carcinoma

Additional file 4: Figure S2. Boxplots of the associations between the immune response genes and the 34-gene signature with PD-L1 expression on tumor cells (TC) and immune cells (IC) and CD8 infiltration in the tumor margin and in the tumor center.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b7c367c3dff752fc8da8a852cae6a3

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Targeting AKT elicits tumor suppressive functions of FOXO transcription factors and GSK3 kinase in Multiple Myeloma

Autor: Timon A. Bloedjes, E. E. Eldering, Marcel Spaargaren, G. de Wilde, Jeroen E. J. Guikema, C. J. M. Van Noesel, Chiel Maas, Richard J. Bende, S. T. Pals

The phosphatidylinositide-3 kinases (PI3K) and the downstream mediator AKT drive survival and proliferation of multiple myeloma (MM) cells and several AKT inhibitors are currently being tested in clinical trials for MM patients. AKT inhibition has pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76d8f9f4e66d8a4d0de1e116d0122f7
https://doi.org/10.1101/816694

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OP0179 Molecular documentation of the clonal evolution of a diffuse large b-cell lymphoma out of clonally expanded rheumatoid factor-expressing b cells in a sjÖgren’s syndrome patient

Autor: Jeroen E. J. Guikema, Aldo Jongejan, Thera A. M. Wormhoudt, M. J. Kwakkenbos, Linda M. Slot, A. H. C. van Kampen, Richard J. Bende, C. J. M. Van Noesel

Publikováno v: THURSDAY, 14 JUNE 2018.

Background Sjogren’s syndrome (SS) is the autoimmune disease with the highest risk of lymphoma development. SS patients develop most frequently MALT lymphoma and to a lesser extent diffuse large B-cell lymphoma (DLBCL). Previously, we have shown th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5e564f76e12759cda0a6c3a68e60a5d
https://doi.org/10.1136/annrheumdis-2018-eular.4401

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Radiation-induced melanoma-associated leucoderma, systemic antimelanoma immunity and disease-free survival in a patient with advanced-stage melanoma: a case report and immunological analysis

Autor: H.E. Teulings, Gabrielle Krebbers, L. Nieuweboer-Krobotova, J.P.W. van der Veen, Rosalie M. Luiten, Karin J. Willemsen, Esther P. M. Tjin, C. J. M. Van Noesel, E.H. Kemp

Publikováno v: British Journal of Dermatology. 168:733-738

Summary Background Melanoma is an immunogenic tumour. The development of skin depigmentation or melanoma-associated leucoderma (MAL) has been associated with favourable clinical outcome in patients with metastatic melanoma, especially after immunothe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ece6c03860d8d20ae5e6b519ef93443f
https://doi.org/10.1111/bjd.12136

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A multidimensional network approach reveals microRNAs as determinants of the mesenchymal colorectal cancer subtype

Autor: Jan Paul Medema, Louis Vermeulen, Evelyn Fessler, S C Oppeneer, C. J. M. Van Noesel, Marnix Jansen, Evelien Dekker, Hans M. Rodermond, Raju Kandimalla, F De Sousa E Melo, Pramudita R. Prasetyanti, Giorgio Stassi, Xin Wang, J H de Jong, Janneke F. Linnekamp, S R van Hooff, Lan Zhao, Marek Franitza

Publikováno v: Oncogene
Europe PubMed Central
Oncogene, 35(46), 6026-6037. Nature Publishing Group

Colorectal cancer (CRC) is a heterogeneous disease posing a challenge for accurate classification and treatment of this malignancy. There is no common genetic molecular feature that would allow for the identification of patients at risk for developin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a2494314a9d63dc9b26caa22366b63d

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