Impact of (chemo)radiotherapy on immune cell composition and function in cervical cancer patients

Autor: S.H. van der Burg, Sanne Samuels, M.I.E. van Poelgeest, J J van Ham, Nikki M. Loof, Marij J. P. Welters, G.G. Kenter, Remi A. Nout, C. J. M. Melief, H. van Meir, Adam F. Cohen, M. L. de Kam, Jacobus Burggraaf

Publikováno v: Oncoimmunology
OncoImmunology, 6(2). Landes Bioscience
OncoImmunology, Vol 6, Iss 2 (2017)
OncoImmunology, 6(2)
van Meir, H, Nout, R A, Welters, M J P, Loof, N M, de Kam, M L, van Ham, J J, Samuels, S, Kenter, G G, Cohen, A F, Melief, C J M, Burggraaf, J, van Poelgeest, M I E & van der Burg, S H 2017, ' Impact of (chemo)radiotherapy on immune cell composition and function in cervical cancer patients ', OncoImmunology, vol. 6, no. 2, pp. e1267095 . https://doi.org/10.1080/2162402X.2016.1267095

New treatments based on combinations of standard therapeutic modalities and immunotherapy are of potential use, but require a profound understanding of immune modulatory properties of standard therapies. Here, the impact of standard (chemo)radiothera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d3d7e0e838c1cb6fbac10f88debf1b
http://europepmc.org/articles/PMC5353924

Minimal information about T cell assays: the process of reaching the community of T cell immunologists in cancer and beyond

Autor: Kunle Odunsi, C. J. M. Melief, Michael Kalos, Cedrik M. Britten, Lloyd J. Old, Holden T. Maecker, Hyam I. Levitsky, Pedro Romero, Bart O. Roep, Christoph Huber, Mark M. Davis, Axel Hoos, Graham Pawelec, Jill O'Donnell-Tormey, Sylvia Janetzki, S.H. van der Burg

Publikováno v: Cancer Immunology, Immunotherapy, 60(1), 15-22
Cancer Immunology, Immunotherapy
Cancer Immunology, Immunotherapy, vol. 60, no. 1, pp. 15-22

Many assays to evaluate the nature, breadth, and quality of antigen-specific T cell responses are currently applied in human medicine. In most cases, assay-related protocols are developed on an individual laboratory basis, resulting in a large number

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39635eb2d9b02448b15054ecf7a7e2f
https://doi.org/10.1007/s00262-010-0940-z

Demonstration of Leucocyte Iso-Antigens on Cells Derived from Skin*

Autor: C. P. Engelfriet, C. J. M. Melief, M. van der Hart, J. N. M. Heersche

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3cac4e92966681fddb1270150738071b
https://doi.org/10.1159/000384686

Creation of immune ‘stealth’ genes for gene therapy through fusion with the Gly-Ala repeat of EBNA-1

Autor: René E. M. Toes, R. Offringa, C. J. M. Melief, Martine Ossevoort, B M J Visser, Rob C. Hoeben, E.I.H. van der Voort, D J M van den Wollenberg

Publikováno v: Gene Therapy. 10:2020-2028

A major obstacle in gene-therapy protocols is T-cell-mediated destruction of transgene-expressing cells. Therefore new approaches are needed to prevent rapid clearance of transduced cells. We exploited the Gly-Ala repeat (GAr) domain of the Epstein-B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e140021204e0ac9968565f69a4ab438
https://doi.org/10.1038/sj.gt.3302098

Pre-clinical safety and efficacy of TA-CIN, a recombinant HPV16 L2E6E7 fusion protein vaccine, in homologous and heterologous prime-boost regimens

Autor: Kitty M. C. Kwappenberg, R.M.P. Brandt, C. J. M. Melief, Julian Hickling, S.H. van der Burg, T. O'Neill, R. Offringa

Publikováno v: Vaccine, 19, 3652-3660. Elsevier

Human papillomavirus (HPV) E6 and E7 oncoproteins are attractive targets for T-cell-based immunotherapy of cervical intraepithelial neoplasia (CIN) and cancer. A newly designed vaccine, comprising the HPV16 L2, E6 and E7 as a single fusion protein (T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26bce7c96dff0aa76b40d46a27a9bddb
https://doi.org/10.1016/s0264-410x(01)00086-x