Zobrazeno 1 - 10 of 249 pro vyhledávání: '"C. J. Larsen"'
3
[Gene MGMT and oligodendrogliomas. Fundamental data and short review of the literature]
Autor: J-L, Blanc, M, Wager, L, Karrayan-Tapon, C-J, Larsen, B, Bataille, F, Lapierre
Publikováno v: Neuro-Chirurgie. 51(3-4 Pt 2)
MGMT (O6 methyl guanine methyl transferase) is a gene involved in DNA repair. Its mechanism of action is to remove alkyl groups created by alkylating chemotherapy and therefore induces chemoresistances. Recent studies show that this gene expression s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db1eb8a9d58e27efc892aeee208e5ba5
https://pubmed.ncbi.nlm.nih.gov/16292171
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6
Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23)
Autor: L, Dahéron, A, Veinstein, F, Brizard, H, Drabkin, L, Lacotte, F, Guilhot, C J, Larsen, A, Brizard, J, Roche
Publikováno v: Genes, chromosomescancer. 31(4)
The mixed lineage leukemia, MLL, gene is frequently rearranged in patients with secondary leukemia following treatment with DNA topoisomerase II inhibitors. By FISH and Southern blot analyses we identified a rearrangement in the MLL gene due to a nov
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::25a1ff65a3e4ba7c4f6c8c1edcb8567e
https://pubmed.ncbi.nlm.nih.gov/11433529
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8
Different combinations of genetic/epigenetic alterations inactivate the p53 and pRb pathways in invasive human bladder cancers
Autor: S, Sarkar, K P, Jülicher, M S, Burger, V, Della Valle, C J, Larsen, T R, Yeager, T B, Grossman, R W, Nickells, C, Protzel, D F, Jarrard, C A, Reznikoff
Publikováno v: Cancer research. 60(14)
Inactivation of both the pRb (pRb-cyclin D1/cyclin-dependent kinase 4/6-p16) and p53 (p53-p21(WAF1)-p14(ARF)) pathways is thought to be essential for immortalization in vitro and malignant transformation in vivo. We identified different combinations
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3b8112422a27880f2452955c18de14a
https://pubmed.ncbi.nlm.nih.gov/10919661
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9
[The ARF-p53 pathway: a line of defence against oncogenic signals]
Autor: C J, Larsen
Publikováno v: Pathologie-biologie. 48(3)
The MTS1 (Multiple Tumor Suppressor 1) locus is a very original one as its organization results in the expression of two alternative transcripts that encode two structurally and functionally different proteins: INK4a and ARF (also designated p19ARF i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d57bfe09c3bb2b2b1d45d0a07d5afa71
https://pubmed.ncbi.nlm.nih.gov/10858963
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