Výsledky vyhledávání - "C. J. Kirkpatrick"

Thermal treatment at 500°C significantly reduces the reaction to irregular tricalcium phosphate granules as foreign bodies: An in vivo study

Autor: Marc Bohner, Mike Barbeck, Sarah Al-Maawi, Shahram Ghanaati, Rainer J. Egli, C. J. Kirkpatrick, Robert Sader, Carlos Herrera Vizcaíno

Publikováno v: Acta Biomaterialia. 142:414-429

Evaporation of phosphate species during thermal treatment (> 400 °C) of calcium phosphates leads to the formation of an alkaline layer on their surface. The aim of this study was to evaluate the hypothesis that the biological response of thermally t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839cc485bb192dbab90ba1d554e8af6a
https://doi.org/10.1016/j.actbio.2022.01.011

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Covalent linkage of sulfated hyaluronan to the collagen scaffold Mucograft® enhances scaffold stability and reduces proinflammatory macrophage activation in vivo

Autor: C. J. Kirkpatrick, Sarah Al-Maawi, Sandra Rother, Karen M. Fiebig, Stephanie Moeller, Hans-Peter Wiesmann, Matthias Schnabelrauch, Norbert Halfter, Shahram Ghanaati, Vera Hintze, Juliane Moritz, Robert Sader, Dieter Scharnweber

Publikováno v: Bioactive Materials, Vol 8, Iss, Pp 420-434 (2022)
Bioactive Materials

Sulfated glycosaminoglycans (sGAG) show interaction with biological mediator proteins. Although collagen-based biomaterials are widely used in clinics, their combination with high-sulfated hyaluronan (sHA3) is unexplored. This study aims to functiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9298c3a975fffe129bca2cb354249c
https://doi.org/10.1016/j.bioactmat.2021.06.008

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Multinucleated giant cells within the in vivo implantation bed of a collagen-based biomaterial determine its degradation pattern

Autor: Alica Kubesch, Sarah Al-Maawi, Anna Maria Tanneberger, Robert Sader, C. J. Kirkpatrick, Shahram Ghanaati, Carlos Herrera-Vizcaino, Anna Orlowska

Publikováno v: Clinical Oral Investigations

Objectives The aim of the present study was to characterize the cellular reaction to a xenogeneic resorbable collagen membrane of porcine origin using a subcutaneous implantation model in Wistar rats over 30 days. Materials and methods Ex vivo, liqui

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b597377ed0684d1525a26b2ff4fb64
https://doi.org/10.1007/s00784-020-03373-7

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Co-culture Model for Cutaneous Wound Healing to Assess a Porous Fiber-Based Drug Delivery System

Autor: Andreas Scherrieble, Michael Doser, C. J. Kirkpatrick, Shahram Ghanaati, Sarah Al-Maawi, Martin Hoss, Eva Dohle, Martin Dauner, Robert Sader

Publikováno v: Tissue engineering. Part C, Methods. 26(9)

In vitro tissue-engineered cell culture models are an essential instrument to investigate physiological and pathophysiological wound healing mechanisms and to evaluate new beneficial wound dressing materials and therapeutics to identify possible drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c2f9294abb0cbc6aeaffc087f0a0c5
https://pubmed.ncbi.nlm.nih.gov/32829670

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A low-speed centrifugation concept leads to cell accumulation and vascularization of solid platelet-rich fibrin: an experimental study in vivo

Autor: Anna Orlowska, C. J. Kirkpatrick, Joseph Choukroun, Patrick Booms, Sarah Al-Maawi, Mike Barbeck, Robert Sader, Richard J. Miron, Shahram Ghanaati, Alica Kubesch

Publikováno v: Platelets. 30:329-340

Platelet-rich fibrin (PRF) is generated from the patients' own venous blood by a single centrifugation step without the additional use of anticoagulants. Based on the previously described LSCC (low-speed centrifugation concept), our group showed that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9fae5b719bacc99145689ed3431bf25
https://doi.org/10.1080/09537104.2018.1445835

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Analysis of the in vitro degradation and the in vivo tissue response to bi-layered 3D-printed scaffolds combining PLA and biphasic PLA/bioglass components – Guidance of the inflammatory response as basis for osteochondral regeneration

Autor: Mike Barbeck, Patrick Booms, Tiziano Serra, C. J. Kirkpatrick, Robert Sader, Elisabeth Engel, Stevo Najman, Melba Navarro, Sanja Stojanović, Shahram Ghanaati

Publikováno v: Bioactive Materials, Vol 2, Iss 4, Pp 208-223 (2017)
Bioactive Materials

The aim of the present study was the in vitro and in vivo analysis of a bi-layered 3D-printed scaffold combining a PLA layer and a biphasic PLA/bioglass G5 layer for regeneration of osteochondral defects in vivo Focus of the in vitro analysis was on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b6dfa811e8a0676e58053e99240ffa
https://doi.org/10.1016/j.bioactmat.2017.06.001

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Reduction of relative centrifugal forces increases growth factor release within solid platelet-rich-fibrin (PRF)-based matrices: a proof of concept of LSCC (low speed centrifugation concept)

Autor: Alica Kubesch, Joseph Choukroun, S. Ghanaati, Anna Orlowska, Patrick Booms, Sarah Al-Maawi, C. J. Kirkpatrick, Andre Dias, K. El Bagdadi, Eva Dohle, R.A. Sader, X. Yu

Publikováno v: European Journal of Trauma and Emergency Surgery

Purpose The present study evaluated the platelet distribution pattern and growth factor release (VEGF, TGF-β1 and EGF) within three PRF (platelet-rich-fibrin) matrices (PRF, A-PRF and A-PRF+) that were prepared using different relative centrifugatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4db189b00ed9b4835e4e4fc0605e52e
https://doi.org/10.1007/s00068-017-0785-7

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Multinucleated giant cells in the implant bed of bone substitutes are foreign body giant cells-New insights into the material-mediated healing process

Autor: Patrick Booms, Ronald E. Unger, Shahram Ghanaati, Robert Sader, Verena Hoffmann, Mike Barbeck, C. J. Kirkpatrick

Publikováno v: Journal of Biomedical Materials Research Part A. 105:1105-1111

In addition to macrophages, multinucleated giant cells (MNGCs) are involved in the tissue reaction to a variety of biomaterials. Especially in the case of bone substitute materials it has been assumed that the MNGCs are osteoclasts, based on the chem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80b38947b729cbd693ab4b96972a3ee6
https://doi.org/10.1002/jbm.a.36006

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Modification of collagen-based sponges can induce an upshift of the early inflammatory response and a chronic inflammatory reaction led by M1 macrophages: an in vivo study

Autor: Joseph Choukroun, Sarah Al-Maawi, Robert Sader, Shahram Ghanaati, Carlos Herrera-Vizcaino, C. J. Kirkpatrick

Publikováno v: Clinical oral investigations. 24(10)

Background The present study evaluated the cellular tissue reaction of two equine-derived collagen hemostatic sponges (E-CHS), which differed in thickness after pressing, over 30 days in vivo. The inflammatory response during physiological wound heal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38576edcb3335dcf15fde4283fe5a12
https://pubmed.ncbi.nlm.nih.gov/32065310

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Platelet-rich fibrin secretome induces three dimensional angiogenic activation in vitro

Autor: C, Herrera-Vizcaíno, E, Dohle, S, Al-Maawi, P, Booms, R, Sader, C J, Kirkpatrick, J, Choukroun, S, Ghanaati

Publikováno v: European cellsmaterials. 37

Different tissue engineering techniques are used to support rapid vascularisation. A novel technique is the use of platelet-rich fibrin (PRF), an autologous source of growth factors. This study was the first to investigate the influence of PRF matric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::39b7afff1fff70a6bfe071a64149f6f2
https://pubmed.ncbi.nlm.nih.gov/30963526

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