Zobrazeno 1 - 10
of 51
pro vyhledávání: '"C. J. Kenyon"'
Autor:
G. Hooper, S. Marshall, J. S. McCRACKEN, Ian R. Wilding, C. J. Kenyon, J. Armbrecht, S. Chauhan, H. J. Staab
Publikováno v:
Alimentary Pharmacology & Therapeutics. 9:161-166
SUMMARY Background: Rectal foam enemas provide for drug delivery to the distal colon for treatment of left sided ulcerative colitis. However, currently available formulations contain chlorofluorocarbons which are due to be phased out in the near futu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6161c7a607fae21d1ccc0c794299c392
https://doi.org/10.1111/j.1365-2036.1995.tb00365.x
https://doi.org/10.1111/j.1365-2036.1995.tb00365.x
Autor:
E A, Rog-Zielinska, M-A, Craig, J R, Manning, R V, Richardson, G J, Gowans, D R, Dunbar, K, Gharbi, C J, Kenyon, M C, Holmes, D G, Hardie, G L, Smith, K E, Chapman
Publikováno v:
Cell Death and Differentiation
Glucocorticoid levels rise dramatically in late gestation to mature foetal organs in readiness for postnatal life. Immature heart function may compromise survival. Cardiomyocyte glucocorticoid receptor (GR) is required for the structural and function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b71ec597ed1c2a8a488df6ad35a72e3
https://pubmed.ncbi.nlm.nih.gov/25361084
https://pubmed.ncbi.nlm.nih.gov/25361084
Publikováno v:
Pharmaceutical Research. 15:417-422
Purpose. To evaluate mechanistically the effect of food on the absorption and gastrointestinal transit of the protease inhibitor saquinavir.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::166c07aaf0859cfa69a04563730f1e2a
https://doi.org/10.1023/a:1011972230829
https://doi.org/10.1023/a:1011972230829
Publikováno v:
Journal of Human Hypertension. 11:453-458
In non-pregnant individuals, abnormalities in cation transport in vascular tissues have been linked to essential hypertension. In the present study, we consider whether Na+/H+ exchange (NHE) is affected in non-proteinuric pre-eclampsia (NPP). Platele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1fc9db1e77dcb14cb9de96ea6a5d38
https://doi.org/10.1038/sj.jhh.1000474
https://doi.org/10.1038/sj.jhh.1000474
Publikováno v:
Alimentary Pharmacology and Therapeutics. 11:205-213
Background: Colonic delivery of corticosteroids may reduce the side-effects commonly associated with their use. Therefore, we tested the ability of the naturally occurring polysaccharide guar gum to deliver a corticosteroid, dexamethasone, to the col
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620584643db45be079d5adf8c61f939f
https://doi.org/10.1046/j.1365-2036.1997.93265000.x
https://doi.org/10.1046/j.1365-2036.1997.93265000.x
Autor:
D Caron, Dawn A. Adkin, Abraham Rubinstein, E. Strauss, Ian R. Wilding, I. Landau, Adel Penhasi, C J Kenyon, E. I. Lerner
Publikováno v:
Pharmaceutical Research. 14:103-107
Purpose. The aim of the present study was to provide 'proof of concept' data in man for novel polysaccharide preparations designed for colonic drug delivery using gamma scintigraphy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::611b989e8980e25e8b7f52bb3c2fe67d
https://doi.org/10.1023/a:1012019820603
https://doi.org/10.1023/a:1012019820603
Autor:
J. M. Humphries, S.P. Newman, G. Hooper, J. Burt, S. Haines, Ian R. Wilding, J. Brown, S.S. Davis, R.A. Sparrow, C. J. Kenyon
Publikováno v:
Pharmaceutical Research. 14:1073-1078
Purpose. In this paper we report on the first scintigraphic evaluation of vaginal dosage forms in post-menopausal women. To date, almost nothing is known about the in vivo performance of pharmaceutical formulations in the human vagina, which is a maj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc9049366b0965d4fe8721ea8f1eb90f
https://doi.org/10.1023/a:1012113714552
https://doi.org/10.1023/a:1012113714552
Publikováno v:
Journal of Controlled Release. 34:31-36
The in vivo behaviour of a novel sustained release formulation of naproxen was investigated using gamma scintigraphy in eight healthy male volunteers under fasted and fed conditions. Disintegration of the tablet into discrete sustained release pellet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48c9ad854b1091630891799dd2b30c0d
https://doi.org/10.1016/0168-3659(94)00118-e
https://doi.org/10.1016/0168-3659(94)00118-e
Autor:
C, Yang, M, Nixon, C J, Kenyon, D E W, Livingstone, R, Duffin, A G, Rossi, B R, Walker, R, Andrew
Publikováno v:
British journal of pharmacology. 164(6)
Dissociating anti-inflammatory efficacy from the metabolic side effects of glucocorticoids is an attractive therapeutic goal. 5α-Tetrahydro-corticosterone (5αTHB), produced from corticosterone by 5α-reductases, activates glucocorticoid receptors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf08c38ee6c9a740a6e2fc5c2b90624b
https://pubmed.ncbi.nlm.nih.gov/21542833
https://pubmed.ncbi.nlm.nih.gov/21542833
Autor:
G C Inglis, C. J. Kenyon
Publikováno v:
Endocrinology. 131:2941-2945
Plasma, kidney, and adrenal catecholamine concentrations were varied by infusing rats with L-dopa and/or carbidopa for 2 weeks. L-Dopa infusion (300 micrograms/day) increased dopamine concentrations in plasma, adrenal zona glomerulosa, and kidney by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354895edba08378fbed8e34f152bbd4e
https://doi.org/10.1210/endo.131.6.1446631
https://doi.org/10.1210/endo.131.6.1446631