Zobrazeno 1 - 10
of 31
pro vyhledávání: '"C. J. Froelich"'
Publikováno v:
The Journal of Immunology. 156:2585-2590
Granzymes, serine proteases located in the granules of cytotoxic T cel ls and NK cells, are essential for induction of target cell apoptosis. However, since cytotoxic cells constitutively secrete a portion of their synthesized granzymes, these protea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3398f1fe6e7754f584c1e48d743ce85
https://doi.org/10.4049/jimmunol.156.7.2585
https://doi.org/10.4049/jimmunol.156.7.2585
Publikováno v:
The Journal of Immunology. 155:895-901
alpha-Thrombin is a multifunctional serine protease that has an important role in the coagulation cascade, wound healing, and inflammatory response. In this study, we show that thrombin induces IL-6 production in human epithelial cells and fibroblast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76ffceb9cd0e368945dfe10790fd756d
https://doi.org/10.4049/jimmunol.155.2.895
https://doi.org/10.4049/jimmunol.155.2.895
Publikováno v:
The Journal of Immunology. 153:4663-4672
We identified a chymotrypsin-like activity in the granules of IL-2 lymphokine-activated killer (LAK) cells and a NK cell line (YT) that reacted preferentially with the oligopeptide substrate succinyl-Phe-Leu-Phe-thiobenzyl ester (Suc-Phe-Leu-Phe-SBzl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80d0aa2bc24eb6cf983b1d257564b8ea
https://doi.org/10.4049/jimmunol.153.10.4663
https://doi.org/10.4049/jimmunol.153.10.4663
Publikováno v:
The Journal of Immunology. 151:7161-7171
Cartilage degradation, a hallmark of rheumatoid arthritis, is attributed to serine and metalloproteases secreted by neutrophils, synovial lining cells, macrophages, and chondrocytes. A large proportion of synovial fluid lymphocytes contains the granu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::172825d87e6b37c3dbb6924cab45e216
https://doi.org/10.4049/jimmunol.151.12.7161
https://doi.org/10.4049/jimmunol.151.12.7161
Autor:
R G, Uzzo, V, Kolenko, C J, Froelich, C, Tannenbaum, L, Molto, A C, Novick, N H, Bander, R, Bukowski, J H, Finke
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(10)
The antitumor effect of T cells is executed either through CD95 or Perforin (PFN)/Granzyme B (GrB) pathways. Induction of apoptosis by either mode requires activation of caspase family members. However, recent studies have suggested that cell death c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65aff2865a172dfa371780b96da4b44d
https://pubmed.ncbi.nlm.nih.gov/11595725
https://pubmed.ncbi.nlm.nih.gov/11595725
Publikováno v:
Cancer research. 61(1)
MCF-7, a breast cancer-derived cell line, is deficient of caspase 3 and relatively insensitive to many chemotherapeutic agents. To study the association of caspase 3 deficiency and chemotherapeutic resistance, we reconstituted caspase 3 in MCF-7 cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::291e7b8629f54655a439fb78ffd7bd4b
https://pubmed.ncbi.nlm.nih.gov/11196185
https://pubmed.ncbi.nlm.nih.gov/11196185
Publikováno v:
Methods in enzymology. 322
Granzyme B (GrB) is the primary molecular mediator of apoptosis by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. It is a unique mammalian aspartic acid-cleaving serine protease. On T cell receptor activation, GrB is released from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::90199f7758b4339291efe4166dde417a
https://pubmed.ncbi.nlm.nih.gov/10914010
https://pubmed.ncbi.nlm.nih.gov/10914010
Publikováno v:
Blood. 95(4)
Granzyme A (GrA) and B (GrB) together with perforin are the main constituents of cytotoxic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. The cytotoxic proteins are released to deliver a lethal hit during contact between th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ce229a1a48490921944dc63480c1fe5
https://pubmed.ncbi.nlm.nih.gov/10666226
https://pubmed.ncbi.nlm.nih.gov/10666226
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(9)
Lymphocyte granule-mediated apoptosis occurs by perforin-mediated intracellular delivery of granule-associated serine proteases (granzymes). A granule-associated proteoglycan, namely serglycin, that contains chondroitin 4-sulfate (CS) glycosaminoglyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa666d5de8a2c0a7d564186fd7e88875
https://pubmed.ncbi.nlm.nih.gov/10228010
https://pubmed.ncbi.nlm.nih.gov/10228010
Autor:
X, Yang, H R, Stennicke, B, Wang, D R, Green, R U, Jänicke, A, Srinivasan, P, Seth, G S, Salvesen, C J, Froelich
Publikováno v:
The Journal of biological chemistry. 273(51)
Granzyme B (GrB) is predicted to trigger apoptosis by activating preferred caspases, but the zymogens that are directly processed by the granzyme and the requirements for these interactions remain unclarified. We examined this dilemma by comparing th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5a2793d6f52328dcde70af2f5e685f0
https://pubmed.ncbi.nlm.nih.gov/9852092
https://pubmed.ncbi.nlm.nih.gov/9852092