Extracellular activities of human granzyme A. Monocyte activation by granzyme A versus alpha-thrombin

Autor: L E Sower, C J Froelich, N Allegretto, P M Rose, W D Hanna, G R Klimpel

Publikováno v: The Journal of Immunology. 156:2585-2590

Granzymes, serine proteases located in the granules of cytotoxic T cel ls and NK cells, are essential for induction of target cell apoptosis. However, since cytotoxic cells constitutively secrete a portion of their synthesized granzymes, these protea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3398f1fe6e7754f584c1e48d743ce85
https://doi.org/10.4049/jimmunol.156.7.2585

Dominant chymotrypsin-like esterase activity in human lymphocyte granules is mediated by the serine carboxypeptidase called cathepsin A-like protective protein

Autor: W L Hanna, J M Turbov, H L Jackman, F Tan, C J Froelich

Publikováno v: The Journal of Immunology. 153:4663-4672

We identified a chymotrypsin-like activity in the granules of IL-2 lymphokine-activated killer (LAK) cells and a NK cell line (YT) that reacted preferentially with the oligopeptide substrate succinyl-Phe-Leu-Phe-thiobenzyl ester (Suc-Phe-Leu-Phe-SBzl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80d0aa2bc24eb6cf983b1d257564b8ea
https://doi.org/10.4049/jimmunol.153.10.4663

Patient‐Derived Tumor Organoids Combined with Function‐Associated ScRNA‐Seq for Dissecting the Local Immune Response of Lung Cancer.

Autor: Liu, Chang¹, Li, Kaiyi¹, Sui, Xizhao², Zhao, Tian¹, Zhang, Ting³, Chen, Zhongyao¹, Wu, Hainan³, Li, Chao², Li, Hao², Yang, Fan², Liu, Zhidong⁴, Lu, You‐Yong⁵, Wang, Jun² wangjun@pkuph.edu.cn, Chen, Xiaofang³ xfchen@buaa.edu.cn, Liu, Peng^1,6 pliu@tsinghua.edu.cn

Publikováno v: Advanced Science. 8/21/2024, Vol. 11 Issue 31, p1-18. 18p.

Engineering of a Multi-Modular DNA Nanodevice for Spatioselective Imaging and Evaluation of NK Cell-Mediated Cancer Immunotherapy.

Autor: Chen ZP; Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China., Zeng WJ; Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China., Lei YM; Institute of Developmental Biology and Regenerative Medicine, Southwest University, Chongqing, 400715, China., Liang WB; Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China., Yang X; Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China., Yuan R; Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China., Yang C; Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.; The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China., Zhuo Y; Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Oct 07, pp. e202414064. Date of Electronic Publication: 2024 Oct 07.

Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis

Autor: X H, Yang, T L, Sladek, X, Liu, B R, Butler, C J, Froelich, A D, Thor

Publikováno v: Cancer research. 61(1)

MCF-7, a breast cancer-derived cell line, is deficient of caspase 3 and relatively insensitive to many chemotherapeutic agents. To study the association of caspase 3 deficiency and chemotherapeutic resistance, we reconstituted caspase 3 in MCF-7 cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::291e7b8629f54655a439fb78ffd7bd4b
https://pubmed.ncbi.nlm.nih.gov/11196185