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Akademický článek

Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs

Autor: A. Lorzadeh, C. Hammond, F. Wang, D. J. H. F. Knapp, J. CH. Wong, J. Y. A. Zhu, Q. Cao, A. Heravi-Moussavi, A. Carles, M. Wong, Z. Sharafian, J. Steif, M. Moksa, M. Bilenky, P. M. Lavoie, C. J. Eaves, M. Hirst

Publikováno v: BMC Biology, Vol 20, Iss 1, Pp 1-23 (2022)

Abstract Background Lifelong production of the many types of mature blood cells from less differentiated progenitors is a hierarchically ordered process that spans multiple cell divisions. The nature and timing of the molecular events required to int

Externí odkaz: https://doaj.org/article/323a789235c74537b3d3137709c319fd

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Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs

Publikováno v: BMC biology. 20(1)

Background Lifelong production of the many types of mature blood cells from less differentiated progenitors is a hierarchically ordered process that spans multiple cell divisions. The nature and timing of the molecular events required to integrate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac2c5f846ac24218328f63b754b468c
https://pubmed.ncbi.nlm.nih.gov/35550087

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Identification of properties that can distinguish primitive populations of stromal-cell-responsive lympho-myeloid cells from cells that are stromal-cell-responsive but lymphoid-restricted and cells that have lympho-myeloid potential but are also capable of competitively repopulating myeloablated recipients

Autor: M E, Lemieux, C J, Eaves

Publikováno v: Blood. 88:1639-1648

We have recently described a modification of the long-term culture- initiating cell (LTC-IC) assay that allows the identification and quantitation of a subset of murine LTC-IC that are able to generate both myeloid and lymphoid progeny in vitro. Thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06774e490ef4f721018552329b45a58a
https://doi.org/10.1182/blood.v88.5.1639.bloodjournal8851639

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BCR-ABL expression in different subpopulations of functionally characterized Ph+ CD34+ cells from patients with chronic myeloid leukemia

Autor: V, Maguer-Satta, A L, Petzer, A C, Eaves, C J, Eaves

Publikováno v: Blood. 88:1796-1804

In patients with chronic myeloid leukemia (CML), the leukemic (BCR- ABL+/Ph+) clone typically includes cells belonging to all of the myeloid lineages and frequently some B cells. From such observations it has been inferred that the initial BCR-ABL ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c97759f39aecfaace4f642abcfe4f49
https://doi.org/10.1182/blood.v88.5.1796.bloodjournal8851796

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Differentiation-associated changes in CD44 isoform expression during normal hematopoiesis and their alteration in chronic myeloid leukemia

Autor: S, Ghaffari, G J, Dougherty, P M, Lansdorp, A C, Eaves, C J, Eaves

Publikováno v: Blood. 86:2976-2985

CD44 is a widely expressed, multifunctional, cell-surface glycoprotein that has been implicated in the regulation of normal hematopoiesis. In addition, expression of particular isoforms of CD44 has been associated with malignant transformation and/or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af894bbe24becc459409fcfb6d3ad414
https://doi.org/10.1182/blood.v86.8.2976.bloodjournal8682976

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Autologous Transplantation in Patients with Acute Myeloid Leukemia in First Remission with IL-2-Cultured Marrow or Peripheral Blood Stem Cells Followed by in vivo IL-2

Autor: Hans G. Klingemann, D.E. Reece, M. J. Barnett, A. C. Eaves, Donna E. Hogge, S. H. Nantel, PL Lansdorp, J. D. Shepherd, C. J. Eaves, Gordon L. Phillips, Heather J. Sutherland

Publikováno v: Oncology Research and Treatment. 18:44-47

Background : Autologous transplantation using the patient’s marrow or peripheral blood stem cells is still plagued by high relapse rates mostly due to the lack of a graft-versus-leuk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95e07b36367ed491d506d73277a856ef
https://doi.org/10.1159/000218553

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Autografting with cultured marrow in chronic myeloid leukemia: results of a pilot study [see comments]

Autor: C. J. Eaves, D. E. Hogge, G. L. Phillips, Humphries Rk, R. D. Gascoyne, Lansdorp Pm, Hans G. Klingemann, M. J. Barnett, S. H. Nantel, DE Horsman

Publikováno v: Blood. 84:724-732

Incubation of chronic myeloid leukemia (CML) marrow for 10 days in vitro causes a marked and selective loss of very primitive Philadelphia chromosome (Ph)+ as compared with Ph- progenitors. We have autografted 22 patients with CML (16 in first chroni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f15936384426ae40f037cdaff4e3c43
https://doi.org/10.1182/blood.v84.3.724.bloodjournal843724

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Mutagenesis of retroviral vectors transducing human beta-globin gene and beta-globin locus control region derivatives results in stable transmission of an active transcriptional structure

Autor: Y. H. Oh, Philippe Leboulch, Dorothy Tuan, G. M. S. Huang, Irving M. London, C. J. Eaves, R. K. Humphries

Publikováno v: The EMBO Journal. 13:3065-3076

Retrovirus-mediated gene transfer of the human beta-globin gene into hematopoietic stem cells is an attractive approach to the therapy of human beta-globin gene disorders. However, expression of the transduced beta-globin gene linked to its proximal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5debfc3c97649c6a331d4cd187573d1
https://doi.org/10.1002/j.1460-2075.1994.tb06605.x

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