Zobrazeno 1 - 2
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pro vyhledávání: '"C. J. Buckholz"'
Autor:
C. J. Buckholz, Rosita J. Rodriguez
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 33(4)
1. This study has examined ketoconazole (KT)-induced hepatotoxicity in vivo and in vitro, using male Sprague-Dawley rats with [(3)H]KT (1.5 micro Ci mg(-1)) at 40 and 90 mg KT kg(-1) doses. Blood and liver samples were collected from 0 to 24 h for al
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(8)
Although ketoconazole is extensively metabolized by hepatic microsomal enzymes, the route of formation and toxicity of suspected metabolites are largely unknown. Reports indicate that N-deacetyl ketoconazole (DAK) is a major initial metabolite in mic