Zobrazeno 1 - 10
of 887
pro vyhledávání: '"C. Irving"'
Autor:
Jiranun Jiratrakanvong, Jinjian Shao, Jiaqi Li, Miguel Menendez Alvarez, Xintian Li, Prajwal Das, Grant Nikseresht, Nikhil Miskin, Ran Huo, Jules Nabon, Tristan Leduc, Eric Zhang, Weikang Ma, Gady Agam, Thomas C. Irving
Publikováno v:
Journal of Synchrotron Radiation, Vol 31, Iss 5, Pp 1401-1408 (2024)
MuscleX is an integrated, open-source computer software suite for data reduction of X-ray fiber diffraction patterns from striated muscle and other fibrous systems. It is written in Python and runs on Linux, Microsoft Windows or macOS. Most modules c
Externí odkaz:
https://doaj.org/article/6394f97a58f94baeabb89283c33f5ba7
Autor:
Anthony L. Hessel, Michel N. Kuehn, Seong-Won Han, Weikang Ma, Thomas C. Irving, Brent A. Momb, Taejeong Song, Sakthivel Sadayappan, Wolfgang A. Linke, Bradley M. Palmer
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract In striated muscle, the sarcomeric protein myosin-binding protein-C (MyBP-C) is bound to the myosin thick filament and is predicted to stabilize myosin heads in a docked position against the thick filament, which limits crossbridge formation
Externí odkaz:
https://doaj.org/article/10a433d29a114c5bb280881b6bad3e35
Autor:
Anthony L. Hessel, Nichlas M. Engels, Michel N. Kuehn, Devin Nissen, Rachel L. Sadler, Weikang Ma, Thomas C. Irving, Wolfgang A. Linke, Samantha P. Harris
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Muscle contraction is produced via the interaction of myofilaments and is regulated so that muscle performance matches demand. Myosin-binding protein C (MyBP-C) is a long and flexible protein that is tightly bound to the thick filament at it
Externí odkaz:
https://doaj.org/article/3e3b21ca5df3481fb34d9c953325e1ab
Autor:
Michelle Rodriguez Garcia, Jeffrey Schmeckpeper, Maicon Landim-Vieira, Isabella Leite Coscarella, Xuan Fang, Weikang Ma, Payton A. Spran, Shengyao Yuan, Lin Qi, Aida Rahimi Kahmini, M. Benjamin Shoemaker, James B. Atkinson, Peter M. Kekenes-Huskey, Thomas C. Irving, Prescott Bryant Chase, Björn C. Knollmann, Jose Renato Pinto
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14572 (2023)
The ACTN2 gene encodes α-actinin 2, located in the Z-disc of the sarcomeres in striated muscle. In this study, we sought to investigate the effects of an ACTN2 missense variant of unknown significance (p.A868T) on cardiac muscle structure and functi
Externí odkaz:
https://doaj.org/article/5f43ec315b34474db0d9718fcffd7e19
Autor:
Peter O. Awinda, Weikang Ma, Kyrah L. Turner, Jing Zhao, Henry Gong, Mindy S. Thompson, Kenneth S. Campbell, Thomas C. Irving, Bertrand C. W. Tanner
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15084 (2022)
Myosin cross-bridges dissociate from actin following Mg2+-adenosine triphosphate (MgATP) binding. Myosin hydrolyses MgATP into inorganic phosphate (Pi) and Mg2+-adenosine diphosphate (ADP), and release of these hydrolysis products drives chemo-mechan
Externí odkaz:
https://doaj.org/article/4b3d2da720e0436f80c18278c270a1ce
Autor:
Weikang Ma, Thomas C. Irving
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3052 (2022)
Small angle X-ray fiber diffraction is the method of choice for obtaining molecular level structural information from striated muscle fibers under hydrated physiological conditions. For many decades this technique had been used primarily for investig
Externí odkaz:
https://doaj.org/article/eb6928c4545d4fd0851574416c3bafb1
Publikováno v:
eLS. :1-20
Publikováno v:
The Journal of Physiology. 600:5247-5266
The contractile properties of fast-twitch and slow-twitch skeletal muscles are primarily determined by the myosin isoform content and modulated by a variety of sarcomere proteins. X-ray diffraction studies of regulatory mechanisms in muscle contracti
Autor:
Venus Joumaa, Ian C. Smith, Atsuki Fukutani, Timothy R. Leonard, Weikang Ma, Srboljub M. Mijailovich, Thomas C. Irving, Walter Herzog
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8526 (2021)
Our purpose was to use small-angle X-ray diffraction to investigate the structural changes within sarcomeres at steady-state isometric contraction following active lengthening and shortening, compared to purely isometric contractions performed at the
Externí odkaz:
https://doaj.org/article/29caed81e6854229a9a4f87ee17ca84f
Autor:
Weikang Ma, Carlos L. del Rio, Lin Qi, Momcilo Prodanovic, Srboljub Mijailovich, Christopher Zambataro, Henry Gong, Rafael Shimkunas, Sampath Gollapudi, Suman Nag, Thomas C. Irving
RationaleMavacamten is a novel, FDA-approved, small molecule therapeutic designed to regulate cardiac function at the sarcomere level by selectively but reversibly inhibiting the enzymatic activity of myosin. It shifts myosin towards orderedoffstates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e0258801c43309f8d6d492ae10b7147
https://doi.org/10.1101/2023.04.10.536292
https://doi.org/10.1101/2023.04.10.536292