Zobrazeno 1 - 10
of 46
pro vyhledávání: '"C. Howton"'
Autor:
Emma F. Jones, Timothy C. Howton, Victoria L. Flanary, Amanda D. Clark, Brittany N. Lasseigne
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-16 (2024)
Abstract Alternative splicing (AS) contributes to the biological heterogeneity between species, sexes, tissues, and cell types. Many diseases are either caused by alterations in AS or by alterations to AS. Therefore, measuring AS accurately and effic
Externí odkaz:
https://doaj.org/article/886828797be44df2ac40fc1ae2c4e865
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Alzheimer’s disease is the most common cause of dementia and is characterized by amyloid-β plaques, tau neurofibrillary tangles, and neuronal loss. Although neuronal loss is a primary hallmark of Alzheimer’s disease, it is kn
Externí odkaz:
https://doaj.org/article/8bb2bd0ed74f487fb8fd59b64dc9c11c
Autor:
Jennifer L. Fisher, Elizabeth J. Wilk, Vishal H. Oza, Sam E. Gary, Timothy C. Howton, Victoria L. Flanary, Amanda D. Clark, Anita B. Hjelmeland, Brittany N. Lasseigne
Publikováno v:
FEBS Open Bio, Vol 14, Iss 5, Pp 803-830 (2024)
Drug repurposing is promising because approving a drug for a new indication requires fewer resources than approving a new drug. Signature reversion detects drug perturbations most inversely related to the disease‐associated gene signature to identi
Externí odkaz:
https://doaj.org/article/f40949cccc344b50a5660d71408edfbd
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0296328 (2024)
The SET binding protein 1 (SETBP1) gene encodes a transcription factor (TF) involved in various cellular processes. Variants in SETBP1 can result in three different diseases determined by the introduction (germline vs. somatic) and location of the va
Externí odkaz:
https://doaj.org/article/d9df04adfc8e4ccab895c30f4b66231f
Autor:
Elizabeth J. Wilk, Timothy C. Howton, Jennifer L. Fisher, Vishal H. Oza, Ryan T. Brownlee, Kasi C. McPherson, Hannah L. Cleary, Bradley K. Yoder, James F. George, Michal Mrug, Brittany N. Lasseigne
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-21 (2023)
Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) is one of the most prevalent monogenic human diseases. It is mostly caused by pathogenic variants in PKD1 or PKD2 genes that encode interacting transmembrane proteins polycystin
Externí odkaz:
https://doaj.org/article/a29d831d0f624c96a1f2239ed4a5233e
Autor:
Vishal H Oza, Jordan H Whitlock, Elizabeth J Wilk, Angelina Uno-Antonison, Brandon Wilk, Manavalan Gajapathy, Timothy C Howton, Austyn Trull, Lara Ianov, Elizabeth A Worthey, Brittany N Lasseigne
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 1, p e1010749 (2023)
With an increasing amount of biological data available publicly, there is a need for a guide on how to successfully download and use this data. The 10 simple rules for using public biological data are: (1) use public data purposefully in your researc
Externí odkaz:
https://doaj.org/article/e2f1a4d14283452ea313b1f657253d45
Autor:
Hadia Ahmed, T. C. Howton, Yali Sun, Natascha Weinberger, Youssef Belkhadir, M. Shahid Mukhtar
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nodes with high centrality in protein–protein interaction (PPI) networks are known to be essential in some organisms. Here, the authors in contrast find that in the interactome of A. thaliana central nodes are enriched in conditional and immune phe
Externí odkaz:
https://doaj.org/article/a64fd292ad4442d9ad1237cf1879b916
Autor:
Victoria L. Flanary, Jennifer L. Fisher, Elizabeth J. Wilk, Timothy C. Howton, Brittany N. Lasseigne
As cancer remains resistant to several modes of treatment, novel therapeutics are still under active investigation to overcome treatment inefficacy in cancer. Given the high attrition rate of de novo drug discovery, drug screening, and drug repurposi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::279e1db314bb1aa7021af039e6795952
https://doi.org/10.20944/preprints202305.1637.v1
https://doi.org/10.20944/preprints202305.1637.v1
Autor:
Jennifer L. Fisher, Elizabeth J. Wilk, Vishal H. Oza, Timothy C. Howton, Victoria Flanary, Amanda D. Clark, Anita B. Hjelmeland, Brittany N. Lasseigne
SummaryDrug repurposing is promising because approving a drug for a new indication requires fewer resources than approving a new drug. Signature reversion detects drug perturbations most inversely related to the disease-associated gene signature to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78caf3d321d57b53aa5edd823145c1f8
https://doi.org/10.1101/2023.03.10.532074
https://doi.org/10.1101/2023.03.10.532074
Autor:
Fei Gao, Christopher M. Garner, M. Shahid Mukhtar, Benjamin J. Spears, Walter Gassmann, T C Howton
Publikováno v:
Molecular Plant-Microbe Interactions®. 32:540-549
One layer of the innate immune system allows plants to recognize pathogen-associated molecular patterns (PAMPS), activating a defense response known as PAMP-triggered immunity (PTI). Maintaining an active immune response, however, comes at the cost o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b089f1d3447ef8bc3c1807b1696ed651
https://doi.org/10.1094/mpmi-07-18-0201-fi
https://doi.org/10.1094/mpmi-07-18-0201-fi