Zobrazeno 1 - 10
of 24
pro vyhledávání: '"C. Howard Barton"'
Autor:
Sophie J. Hesketh, Zoe Stroud, Alvin C. K. Teo, Timothy R. Dafforn, Sarah C. Lee, Corinne J. Smith, David I. Roper, Timothy J. Knowles, Corinne M. Spickett, Megha Rai, Pooja Sridhar, J. Malcolm East, Mayuriben J. Parmar, Stephen P Muench, Kailene S. Simon, Richard Collins, Vincent L. G. Postis, Saskia E. Bakker, C. Howard Barton, Naomi L. Pollock, Gregory Hurlbut
Most membrane proteins function through interactions with other proteins in the phospholipid bilayer, the cytosol or the extracellular milieu. Understanding the molecular basis of these interactions is key to understanding membrane protein function a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4184bd5543023d4d506e72952b00801a
Publikováno v:
Trends in Biochemical Sciences. 35:28-35
Group IIA phospholipase A2 (PLA2) is a low-molecular-mass secreted PLA2 enzyme that has been identified as an acute phase protein with a role in the inflammatory response to infection and trauma. The protein is possibly unique in being highly cationi
Publikováno v:
Journal of Biological Chemistry. 283:5034-5045
Human group IIA phospholipase A2 (IIA PLA2) is an acute phase protein first identified at high concentrations in synovial fluid from patients with rheumatoid arthritis. Its physiological role has since been debated; the enzyme has a very high affinit
Autor:
C. Howard Barton, Irene Yeung, Abigail Lapham, Michal Alter-Koltunoff, Ben-Zion Levi, Holly Bowen, Derek A. Mann, V. Hugh Perry, E.S. Phillips
Publikováno v:
Journal of Biological Chemistry. 278:36017-36026
Murine Nramp1 encodes a divalent cation transporter that is expressed in late endosomes/lysosomes of macrophages, and the transported cations facilitate intracellular pathogen growth control. The Nramp1 promoter is TATA box-deficient, has two initiat
Publikováno v:
European Journal of Immunology. 31:2060-2070
Nramp1 controls responses to infection and encodes a biallelic (G169D) macrophage-restricted divalent-cation transporter. Nramp1(D169) is phenotypically null. We demonstrate Nramp1 is implicated in iron regulation in vivo. In spleen, expression is ex
Publikováno v:
The Journal of biological chemistry. 283(8)
Human group IIA phospholipase A2 (IIA PLA2) is an acute phase protein first identified at high concentrations in synovial fluid from patients with rheumatoid arthritis. Its physiological role has since been debated; the enzyme has a very high affinit
Publikováno v:
The Journal of experimental biology. 209(Pt 10)
SUMMARYNramp (Slc11a1) genes in mammals are associated with the transport of iron and other divalent cations; Nramp1 in macrophages involved in the innate immune response against intracellular pathogens, and Nramp2 with duodenal iron uptake and the t
Autor:
Tomohiko Tamura, Aviva Azriel, Hansjörg Hauser, Keiko Ozato, Ben-Zion Levi, Michal Alter-Koltunoff, Holly Bowen, Natalie Dror, Sharon Ehrlich, Martin Eilers, C. Howard Barton
Publikováno v:
The Journal of biological chemistry. 278(45)
Natural resistance-associated macrophage protein 1 (Nramp1) is a proton/divalent cation antiporter exclusively expressed in monocyte/macrophage cells with a unique role in innate resistance to intraphagosomal pathogens. In humans, it is linked to sev
Autor:
V. Hugh Perry, E.S. Phillips, Holly Bowen, Derek A. Mann, Thelma Biggs, C. Howard Barton, S. T. Baker
Publikováno v:
The Journal of biological chemistry. 277(38)
Iron is essential for growth, and impaired iron homoeostasis through a non-conserved mutation within murine Nramp1, also termed Slc11a1, contributes to susceptibility to infection. Nramp1 depletes the macrophage cytosol of iron, with effects on iron-
Autor:
C. Howard Barton, Peter N. Goodfellow, David P. Kelsell, Frank S. Walsh, Stephen E. Moore, Nigel K. Spurr, Wendy Putt
Publikováno v:
Journal of neurochemistry. 55(3)
cDNA clones encoding the human N-cadherin cell adhesion molecule have been isolated from an embryonic muscle library by screening with an oligonucleotide probe complementary to the chick brain sequence and chick brain cDNA probe lambda N2. Comparison