Ranolazine in High-Risk Patients With Implanted Cardioverter-Defibrillators

Autor: Wojciech Zareba, James P. Daubert, Christopher A. Beck, David T. Huang, Jeffrey D. Alexis, Mary W. Brown, Kathryn Pyykkonen, Scott McNitt, David Oakes, Changyong Feng, Mehmet K. Aktas, Felix Ayala-Parades, Adrian Baranchuk, Marc Dubuc, Mark Haigney, Alexander Mazur, Craig A. McPherson, L. Brent Mitchell, Andrea Natale, Jonathan P. Piccini, Merritt Raitt, Mayer Y. Rashtian, Claudio Schuger, Stephen Winters, Seth J. Worley, Ohad Ziv, Arthur J. Moss, W. Zareba, K. Pyykkonen, A. Buttaccio, E. Perkins, D. DeGrey, S. Robertson, A.J. Moss, M. Brown, R. Lansing, A. Oberer, B. Polonsky, V. Ross, A. Papernov, S. Schleede, C. Beck, D. Oakes, C. Feng, S. McNitt S, W.J. Hall, A. Moss, J. Daubert, D. Huang, S. Winters, C. Schuger, M. Haigney, J. Piccini, J. Alexis, L. Chen, A. Miller, J.F. Richeson, S. Rosero, V. Kutyifa, A. Shah, G. Lamas, F. Cohn, F. Harrell, I. Piña, J. Poole, M. Sullivan, D. Lathrop, N. Geller, R. Boineau, J. Trondell, L. Cooper, E. Itturiaga, C. Gottlieb, S. Greer, C. Perzanowski, C. McPherson, C. Hedgepeth, C. Assal, T. Salam, I. Woollett, G. Tomassoni, F. Ayala-Paredes, A. Russo, S. Punnam, R. Sangrigoli, S. Sloan, S. Kutalek, A. Sun, D. Lustgarten, G. Monir, D. Haithcock, R. Sorrentino, D. Cannom, J. Kluger, S. Varanasi, M. Rashtian, F. Philippon, R. Berger, M. Mazzella, T. Lessmeier, J. Silver, S. Worley, M. Bernabei, D. Esberg, M. Dixon, P. LeLorier, Y. Greenberg, V. Essebag, G. Venkataraman, T. Shinn, M. Dubuc, G. Turitto, C. Henrikson, M. Mirro, M. Raitt, A. Baranchuk, G. O'Neill, E. Lockwood, M. Vloka, J. Hurwitz, R.H. Mead, P. Somasundarum, E. Aziz, E. Rashba, A. Budzikowski, M. Cox, A. Natale, E. Chung, O. Ziv, F. McGrew, K. Tamirisa, A. Greenspon, M. Estes, S. Taylor, R. Janardhanan, L.B. Mitchell, M. Burke, M. Attari, B. Mikaelian, S. Hsu, J. Conti, A. Mazur, S. Shorofsky, L. Rosenthal, S. Sakaguchi, D. Wolfe, G. Flaker, S. Saba, M. Aktas, P. Mason, A. Shalaby, D. Musat, R. Abraham, K. Ellenbogen, C. Fellows, N. Kavesh, G. Thomas, D. Hemsworth, B. Williamson

Publikováno v: Journal of the American College of Cardiology. 72:636-645

Background Ventricular tachycardia (VT) and ventricular fibrillation (VF) remain a challenging problem in patients with implantable cardioverter-defibrillators (ICDs). Objectives This study aimed to determine whether ranolazine administration decreas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a3da108e14703d249a00ad70af08bb8
https://doi.org/10.1016/j.jacc.2018.04.086

Reassessing the ichthyotoxin profile of cultured Prymnesium parvum (golden algae) and comparing it to samples collected from recent freshwater bloom and fish kill events in North America

Autor: Susan L. Mooberry, Majed S. Gharfeh, K. David Hambright, Jon C. Henrikson, Anne C. Easton, Robert H. Cichewicz, Karen L. Glenn, James D. Easton, Miriam Shadfan

Publikováno v: Toxicon. 55:1396-1404

Within the last two decades, Prymnesium parvum (golden algae) has rapidly spread into inland waterways across the southern portion of North America and this organism has now appeared in more northerly distributed watersheds. In its wake, golden algae

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82e7a053dda324fec44292e66a09632
https://doi.org/10.1016/j.toxicon.2010.02.017

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Chemical induction of silent biosynthetic pathway transcription in Aspergillus niger

Autor: Jon C. Henrikson, L. Jackson, K. M. Fisch, Robert H. Cichewicz, M. Gipson, Allison F. Gillaspy, Ashley R. Hoover, F. Z. Najar, Heike Wägele

Publikováno v: Journal of industrial microbiologybiotechnology. 36(9)

Manipulation of the fungal epigenome is hypothesized to be an effective method for accessing natural products from silent biosynthetic pathways. A library of epigenetic modifiers was tested using the fungus Aspergillus niger to determine the impact o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58963de59181fb7331819b7d206bec62
https://pubmed.ncbi.nlm.nih.gov/19521728

Epigenetic remodeling of the fungal secondary metabolome

Autor: Robert H. Cichewicz, Russell B. Williams, Jon C. Henrikson, Andrlynn E. Lee, Ashley R. Hoover

Publikováno v: Organicbiomolecular chemistry. 6(11)

Fungi treated with DNA methyltransferase and histone deacetylase inhibitors exhibited natural product profiles with enhanced chemical diversity demonstrating that small-molecule epigenetic modifiers are effective tools for rationally controlling the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be198efb260d05fe104dca752361bcb
https://pubmed.ncbi.nlm.nih.gov/18480899