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Optimising Chemotherapy for Frail and Older Patients With Advanced Gastroesophageal Cancer: The GO2 Phase III Trial

Autor: Mohammed Abdul Imran Khan, Tania Tillett, Rajarshi Roy, Simon Lord, Zuzana Stokes, Helen Howard, Matthew T. Seymour, Christine Allmark, C. Handforth, Guptal Kamalnayan, Jonathan Nicoll, Eszter Katona, Joseph Mano, Sharon Ruddock, Nick Maisey, David A Cairns, Galina Velikova, Ángel David Roncancio García, Jonathan Wadsley, Anirban Chatterjee, Peter Hall, Daniel Swinson, Stephen Falk, Pei Loo Ow, Helen Marshall, Simon Grumett, Sebastian Cummins, Heike I. Grabsch, Jo Dent, Kamposioras Kostantinos-Vellios, Justin Waters, Russell D. Petty, Anne Crossley, Thomas K. Waddell

Publikováno v: SSRN Electronic Journal.

Background: GO2 sought to optimise chemotherapy dosing in older/frail patients with advanced gastroesophageal cancer, and explored baseline geriatric assessment (GA) as a tool for treatment decision-making. Methods: Patients were recruited for whom f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c59fb829c1f7be74d57753c59513f2eb
https://doi.org/10.2139/ssrn.3724274

Efficacy of Reduced-Intensity Chemotherapy With Oxaliplatin and Capecitabine on Quality of Life and Cancer Control Among Older and Frail Patients With Advanced Gastroesophageal Cancer

Autor: Pei Loo Ow, Angel Garcia, Lesley Samuel, Rajarshi Roy, Adam McGeoch, D. Fyfe, W Saku, Simon Aird Grumett, Jonathan Nicoll, Jo Dent, Tom Samuel Waddell, Jo Webster, Christine Allmark, Tania Tillett, Colin Askill, Justin S. Waters, C. Handforth, Erica Beaumont, Vallipuram Vigneswaran, Sharon Ruddock, Nick Wadd, Syed Zubair, Kinnari Patel, Vanessa Potter, Daniel Propper, Olwyn Williams, Marc Jones, Kamalnayan Guptal, Peter Hall, Gareth Griffiths, Joseph Mano, Juan W. Valle, Sheela Rao, David A Cairns, Go Trial Investigators, Eszter Katona, Nick Maisey, Chris Twelves, Daniel Swinson, Nicholas Reed, Heike I. Grabsch, Joanne Askey, Jonathan Wadsley, Tom Roques, Sue Cheeseman, Stephen Falk, Louise Medley, Arshad Jamil, Emma Cattell, Victori Kunene, Matthew R. Sydes, Charles Candish, Claire Hobbs, Rebecca Herbertson, Jo Parkinson, Nicholas S. Reed, Louise Brook, Zuzana Stokes, Mohammed Khan, Ann Crossley, Elin Jones, George Bozas, Sebastian Cummins, Anirban Chatterjee, Michael Bennet, Helen Marshall, Pavel Bezecny, David Sherriff, Matthew T. Seymour, Lauren Gorf, Galina Velikova, Jean Gall, Kamposioras Konstantinos-Velios, Sally Clive, Eleanor James, Fiona Collinson, Dunca Wilkins, Simon Lord, Julia Brown, Serena Hilman, A. Robinson, Richard Ellis, Alaaeldin Shablak, Russell D Petty, Sherif Raouf, Helen Howard

Publikováno v: Hall, P S, Swinson, D, A. Cairns, D, S. Waters, J, Petty, R, Allmark, C, Ruddock, S, Falk, S, Wadsley, J, Roy, R, Tillett, T, Nicoll, J, Cummins, S, Mano, J, Grumett, S, Stokes, Z, Konstantinos-Velios, K, Chatterjee, A, Garcia, A, Waddell, T, Guptal, K, Maisey, N, Khan, M, Dent, J, Lord, S, Crossley, A, Katona, E, Marshall, H, I. Grabsch, H, Velikova, G, Loo Ow, P, Handforth, C, Howard, H & T. Seymour, M 2021, ' Efficacy of Reduced-Intensity Chemotherapy With Oxaliplatin and Capecitabine on Quality of Life and Cancer Control Among Older and Frail Patients With Advanced Gastroesophageal CancerThe GO2 Phase 3 Randomized Clinical Trial ', JAMA Oncology . https://doi.org/10.1001/jamaoncol.2021.0848
JAMA Oncology, 7(6), 869-877. American Medical Association

Importance: Older and/or frail patients are underrepresented in landmark cancer trials. Tailored research is needed to address this evidence gap. Objective: The GO2 randomized clinical trial sought to optimize chemotherapy dosing in older and/or frai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957a450457d575d4bca5b7ef992b410c
https://doi.org/10.1001/jamaoncol.2021.0848

Chemotherapy for frail and elderly patients (pts) with advanced gastroesophageal cancer (aGOAC): Quality of Life (QoL) results from the GO2 phase III trial

Autor: Simon Lord, Russell D. Petty, Daniel Swinson, Peter Hall, Michael I. Bennett, Galina Velikova, C. Handforth, Matthew T. Seymour, David A Cairns, Helen Marshall

Publikováno v: Annals of Oncology. 30:v879-v880

Background Many pts with aGOAC are elderly and/or frail. GO2 [ASCO 2019 #4006] found that lower dose OxaliplatinCapecitabine (OCap) led to non-inferior progression free survival, less toxicity and better patient-centred outcomes using a novel composi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b966a1882037dffcaaf0eee0fa7c7bc6
https://doi.org/10.1093/annonc/mdz394.037

The prevalence and outcomes of frailty in older cancer patients: a systematic review

Autor: Samantha A Simpkins, C. Handforth, Andrew Clegg, Caroline Young, Matthew T. Seymour, Peter Selby, John Young

Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology. 26(6)

Frailty is a state of vulnerability to poor resolution of homeostasis following a stressor event, such as chemotherapy or cancer surgery. Better knowledge of the epidemiology of frailty could help drive a global cancer care strategy for older people.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256a5883f90016f120dadb905e2e15fb
https://pubmed.ncbi.nlm.nih.gov/25403592