Zobrazeno 1 - 10
of 50
pro vyhledávání: '"C. Haagsma"'
Autor:
Alex N Salazar, Franklin L Nobrega, Christine Anyansi, Cristian Aparicio-Maldonado, Ana Rita Costa, Anna C Haagsma, Anwar Hiralal, Ahmed Mahfouz, Rebecca E McKenzie, Teunke van Rossum, Stan J J Brouns, Thomas Abeel
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 1, p e1007314 (2020)
The last decade has witnessed a remarkable increase in our ability to measure genetic information. Advancements of sequencing technologies are challenging the existing methods of data storage and analysis. While methods to cope with the data deluge a
Externí odkaz:
https://doaj.org/article/6f872a9771584b79a7dacbeed69d8275
Autor:
Sebastian N. Kieper, Cristóbal Almendros, Juliane Behler, Rebecca E. McKenzie, Franklin L. Nobrega, Anna C. Haagsma, Jochem N.A. Vink, Wolfgang R. Hess, Stan J.J. Brouns
Publikováno v:
Cell Reports, Vol 22, Iss 13, Pp 3377-3384 (2018)
Summary: CRISPR-Cas systems adapt their immunological memory against their invaders by integrating short DNA fragments into clustered regularly interspaced short palindromic repeat (CRISPR) loci. While Cas1 and Cas2 make up the core machinery of the
Externí odkaz:
https://doaj.org/article/a553cb692f094045896dfc2de824af60
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The RNA binding protein TRBP is a component of the Dicer complex but its role in microRNA biogenesis remains poorly understood. Here the authors use a crowded RNA environment and single-molecule imaging to show that TRBP acts as a gatekeeper to preve
Externí odkaz:
https://doaj.org/article/7b1687162fec4a0bb83eed9b2f3f28d3
Autor:
Ana Rita Costa, Daan F. van den Berg, Jelger Q. Esser, Aswin Muralidharan, Halewijn van den Bossche, Boris Estrada Bonilla, Baltus A. van der Steen, Anna C. Haagsma, Franklin L. Nobrega, Pieter-Jan Haas, Stan J.J. Brouns
Prokaryotes carry multiple distinct anti-viral defense systems. However, the impact of carrying a multitude of defense systems on virus resistance remains unclear, especially in a clinical context. Using a collection of antibiotic-resistant clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73abe19de0ea9d9492dbae2dbd74f169
https://doi.org/10.1101/2022.08.12.503731
https://doi.org/10.1101/2022.08.12.503731
Autor:
Wen Y. Wu, Simon A. Jackson, Cristóbal Almendros, Anna C. Haagsma, Suzan Yilmaz, Gerrit Gort, John van der Oost, Stan J.J. Brouns, Raymond H.J. Staals
Publikováno v:
CRISPR Journal, 5(4), 536-547
CRISPR Journal 5 (2022) 4
CRISPR Journal, 5(4)
CRISPR Journal 5 (2022) 4
CRISPR Journal, 5(4)
Adaptation of clustered regularly interspaced short palindromic repeats (CRISPR) arrays is a crucial process responsible for the unique, adaptive nature of CRISPR-Cas immune systems. The acquisition of new CRISPR spacers from mobile genetic elements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d183d4d1072520c3173258a384c20f50
https://doi.org/10.1089/crispr.2021.0150
https://doi.org/10.1089/crispr.2021.0150
Autor:
Chunyi Hu, Sam P. B. van Beljouw, Ki Hyun Nam, Gabriel Schuler, Fran Ding, Yanru Cui, Alicia Rodríguez-Molina, Anna C. Haagsma, Menno Valk, Martin Pabst, Stan J. J. Brouns, Ailong Ke
Publikováno v:
Science, 377(6612)
Science
Science
The CRISPR-Cas type III-E RNA-targeting effector complex gRAMP/Cas7-11 is associated with a caspase-like protein (TPR-CHAT/Csx29) to form Craspase (CRISPR-guided caspase). Here, we use cryo–electron microscopy snapshots of Craspase to explain its t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e273e50772fe39e8ccabb059419979b0
http://resolver.tudelft.nl/uuid:f05e287e-4700-48e3-b88f-f7fd35a0743c
http://resolver.tudelft.nl/uuid:f05e287e-4700-48e3-b88f-f7fd35a0743c
Autor:
Jochem N.A. Vink, Cristóbal Almendros, Saket R. Bagde, Ailong Ke, Anna C. Haagsma, Chunyi Hu, Ana Rita Costa, Ki Hyun Nam, Stan J. J. Brouns
Publikováno v:
Nature
Nature: international weekly journal of science, 598(7881)
Nature: international weekly journal of science, 598(7881)
Prokaryotes adapt to challenges from mobile genetic elements by integrating spacers derived from foreign DNA in the CRISPR array1. Spacer insertion is carried out by the Cas1–Cas2 integrase complex2–4. A substantial fraction of CRISPR–Cas syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53581050aa52660499ff98e9b4670f3f
https://europepmc.org/articles/PMC9164213/
https://europepmc.org/articles/PMC9164213/
Autor:
Jochem N.A. Vink, Stan J. J. Brouns, Sam P. B. van Beljouw, Anna C. Haagsma, Alicia Rodríguez-Molina, Daan F. van den Berg
Publikováno v:
Science (New York, N.Y.), 373(6561)
Type III CRISPR-Cas immunity is widespread in prokaryotes and is generally mediated by multi-subunit effector complexes. These complexes recognize complementary viral transcripts and can activate ancillary immune proteins. Here, we describe a type II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03849e097a522cedbf9205056e1fe63e
https://pubmed.ncbi.nlm.nih.gov/34799728
https://pubmed.ncbi.nlm.nih.gov/34799728
Autor:
Cristóbal Almendros, Albert J. R. Heck, Arjan Barendregt, Anna C. Haagsma, Stan J. J. Brouns, Sebastian N. Kieper
Publikováno v:
CRISPR Journal, 4(4)
The immunization of bacteria and archaea against invading viruses via CRISPR adaptation is critically reliant on the efficient capture, accurate processing, and integration of CRISPR spacers into the host genome. The adaptation proteins Cas1 and Cas2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db986000d168d78443b76b426d014df2
http://resolver.tudelft.nl/uuid:271b49f1-d072-4db1-9d00-b53dbf126380
http://resolver.tudelft.nl/uuid:271b49f1-d072-4db1-9d00-b53dbf126380
Autor:
Anna C. Haagsma, Stan J. J. Brouns, Rodrigo Gonzalez-Linares, Franklin L. Nobrega, Jeroen M. Jacques, Timon Idema, Willem Kasper Spoelstra, Marileen Dogterom, Dimphna H. Meijer, Louis Reese
Publikováno v:
Biophys J
The ability to detect specific nucleic acid sequences allows for a wide range of applications such as the identification of pathogens, clinical diagnostics, and genotyping. CRISPR-Cas proteins Cas12a and Cas13a are RNA-guided endonucleases that bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ee91f80be021aa9ebb054aec458990
https://pubmed.ncbi.nlm.nih.gov/33617832
https://pubmed.ncbi.nlm.nih.gov/33617832