Výsledky vyhledávání - "C. H. Heusser"

Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines

Autor: June Roberts, C H Heusser, KM Britten, R Mueller, Stephen Montefort, Peter H. Howarth, Ratko Djukanovic, Stephen T. Holgate, Peter Bradding

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 10:471-480

Asthma is characterized by the presence of an inflammatory cell infiltrate in the bronchial mucosa consisting of activated mast cells, eosinophils, and T cells. Several cytokines are considered to play a pivotal role in this response, particularly in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3144d3d14ab6d3f8599d267418b2c363
https://doi.org/10.1165/ajrcmb.10.5.8179909

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Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation

Autor: P Bradding, I H Feather, S Wilson, P G Bardin, C H Heusser, S T Holgate, P H Howarth

Publikováno v: The Journal of Immunology. 151:3853-3865

Allergic mucosal inflammation is characterized by the presence of cell infiltration, predominantly with IgE-sensitized mast cells and activated eosinophils, and appears to be regulated by the local production and release of several cytokines, particu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43528fa00e5dfbf84700e50ff0228b05
https://doi.org/10.4049/jimmunol.151.7.3853

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Specific VDJ gene combinations contribute to the specificity of memory antibodies to the phosphorylcholine hapten

Autor: M Lötscher, H Amstutz, C H Heusser, K Blaser

Publikováno v: The Journal of Immunology. 148:3631-3635

Based on their fine specificity, two groups of antibodies against the phosphorylcholine (PC) hapten have been described. Group I antibodies react predominantly with the PC moiety of the hapten and group II are directed against the entire hapten inclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5db853f9f0df1287960014a58cb7612c
https://doi.org/10.4049/jimmunol.148.11.3631

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Characterization of a monoclonal antibody specific for human active renin

Autor: J. P. A. Bews, Victor J. Dzau, C. H. Heusser, Richard E. Pratt, Wen Min Zuo, M. M. De Gasparo

Publikováno v: Hypertension. 19:249-254

We have identified and characterized an anti-human renin monoclonal antibody R1-20-5 that is selective for human active renin. R1-20-5 binds active renin with a dissociation constant (Kd) of 2.5 x 10(-7) M/l and inhibits renin enzymatic activity with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c5882462e2afc2c4ed123383ffeea4
https://doi.org/10.1161/01.hyp.19.3.249

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Interleukin 4 is localized to and released by human mast cells

Autor: Peter Bradding, Yoshimichi Okayama, Peter H. Howarth, T C Hunt, R Mueller, J P Bews, C H Heusser, KM Britten, I. Feather, J A Roberts

Publikováno v: The Journal of Experimental Medicine

Recent attention has focused on the T helper type 2 (Th2) lymphocyte as a source of interleukin 4 (IL-4) in allergic disease. However, Th2 cells themselves require a pulse of IL-4 to initiate this synthesis. Here we provide immunohistochemical eviden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2589c1aa7218d7c77d9f2256fd1fc0
http://europepmc.org/articles/PMC2119427

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Radioimmuno positron emission tomography with monoclonal antibodies

Autor: N Hardman, Franz Buchegger, A. Pfeiffer, JP Mach., Gerrit Westera, G. K. von Schulthess, HW Reist, Sharma Hl, C. H. Heusser

Publikováno v: Nuclear Medicine Communications. 12:429-438

Radioimmunodetection of tumours with monoclonal antibodies is becoming an established procedure. Positron emission tomography (PET) shows better resolution than normal gamma camera single photon emission tomography and can provide more precise quanti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::022338fedb6e859410726d1a69fe6e33
https://doi.org/10.1097/00006231-199105000-00007

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In vivo effects of anti-IL-4 monoclonal antibody on neonatal induction of tolerance and on an associated autoimmune syndrome

Autor: S Schurmans, C H Heusser, H Y Qin, J Merino, G Brighouse, P H Lambert

Publikováno v: The Journal of Immunology. 145:2465-2473

The role of IL-4 in the cellular interactions leading to the induction of CTL tolerance to H-2b alloantigens and to the development of a lupus-like autoimmune disease in BALB/c mice after neonatal injection with (C57BL/6 x BALB/c)F1 cells was investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::611ebc7ec6d7e35a88eb8d1733a7a53e
https://doi.org/10.4049/jimmunol.145.8.2465

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Enhancement of human IL-4 activity by soluble IL-4 receptors in vitro

Autor: T, Jung, K, Wagner, C, Neumann, C H, Heusser

Publikováno v: European journal of immunology. 29(3)

The recombinant form of the extracellular domain of the IL-4 receptor (sIL-4R) is a potential candidate to neutralize IL-4; however, murine sIL-4R displayed both antagonistic and agonistic activity in vivo. Here we show that human recombinant sIL-4R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3d3bfd3a1c826b5242572732dc994149
https://pubmed.ncbi.nlm.nih.gov/10092089

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