Výsledky vyhledávání - "C. H. Hardman"

Structure of the A-Domain of HMG1 and Its Interaction with DNA as Studied by Heteronuclear Three- and Four-Dimensional NMR Spectroscopy

Autor: R.W. Broadhurst, Klaus D. Grasser, Andrew R. C. Raine, Jean O. Thomas, C. H. Hardman, Ernest D. Laue

Publikováno v: Biochemistry. 34:16596-16607

HMG1 has two homologous, folded DNA-binding domains ("HMG boxes"), A and B, linked by a short basic region to an acidic C-terminal domain. Like the whole protein, which may perform an architectural role in chromatin, the individual boxes bind to DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a6f200f69fb294c0ac31ae5331106a
https://doi.org/10.1021/bi00051a007

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Backbone Dynamics of the A-Domain of HMG1 As Studied by 15N NMR Spectroscopy

Autor: C. H. Hardman, R. W. Broadhurst, Jean O. Thomas, Ernest D. Laue

Publikováno v: Biochemistry. 34:16608-16617

The HMG-box sequence motif (approximately 80 residues) occurs in a number of abundant eukaryotic chromosomal proteins such as HMG1, which binds DNA without sequence specificity, but with "structure specificity", as well as in several sequence-specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ba4140b96978f03f0da0760f515ba0
https://doi.org/10.1021/bi00051a008

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A 4D HCC(CO)NNH experiment for the correlation of aliphatic side-chain and backbone resonances in 13C/15N-labelled proteins

Autor: Peter J. Domaille, C. H. Hardman, Ernest D. Laue, Wayne Boucher, Robin T. Clowes

Publikováno v: Journal of Biomolecular NMR. 3:349-354

We recently proposed a novel four-dimensional (4D) NMR strategy for the assignment of backbone nuclei in spectra of 13C/15N-labelled proteins (Boucher et al. (1992) J. Am. Chem. Soc., 114, 2262–2264 and J. Biomol. NMR, 2, 631–637). In this paper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04fdcf37f87b5cbee556bcaaa2bd716d
https://doi.org/10.1007/bf00212520

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The Use of Heteronuclear Cross Polarization to Enhance the Sensitivity of Triple-Resonance NMR Experiments. Improved 4D HCNNH Pulse Sequences

Autor: Ernest D. Laue, James Keeler, C. H. Hardman, Julia M. Richardson, Peter J. Domaille, Robin T. Clowes, Wayne Boucher

Publikováno v: Journal of Magnetic Resonance, Series B. 101:223-227

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::efdcbcb10c07db1a1e7045f50f69403b
https://doi.org/10.1006/jmrb.1993.1038

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DNA-binding properties of the tandem HMG boxes of high-mobility-group protein 1 (HMG1)

Autor: Keng-Boon Lee, Klaus D. Grasser, Soo Hwang Teo, R. William Broadhurst, Jean O. Thomas, C. H. Hardman, Christine Rees

Publikováno v: European journal of biochemistry. 253(3)

High-mobility-group protein 1 (HMG1) is a conserved chromosomal protein with two homologous DNA-binding HMG-box domains, A and B, linked by a short basic region to an acidic carboxy-terminal tail. NMR spectroscopy on the free didomain (AB) shows that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed483aef7c507fd5a228987135e978b
https://pubmed.ncbi.nlm.nih.gov/9654080

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