Zobrazeno 1 - 10
of 29
pro vyhledávání: '"C. H. Cashin"'
Publikováno v:
Journal of medicinal chemistry. 10(3)
Publikováno v:
Agents and Actions. 34:332-338
Autor:
D Bradshaw, C R Self, J C Wickens, D. P. Bloxham, Peter James Machin, C H Cashin, B P Tong, W E Barber, C E Smithen, John Mervyn Osbond
Publikováno v:
Journal of Medicinal Chemistry. 34:772-777
The synthesis of a series of substituted heterocyclic alkoxypropionic acids is described. They were evaluated for antiinflammatory effects in two animal models of chronic inflammation; adjuvant arthritis and type II collagen arthritis in the rat. The
Autor:
C. H. Cashin, E. J. Lewis
Publikováno v:
Agents and Actions. 29:59-61
Publikováno v:
Journal of Medicinal Chemistry. 22:1464-1469
Compounds having acenaphthene and indan as their parent nuclei were synthesized for antiinflammatory testing. Compounds which showed activity were 1-phenyl-5-acenaphthenylacetic acid and its alpha-methyl derivative (carrageenan rat paw edema) and the
Publikováno v:
Journal of Pharmacy and Pharmacology. 29:330-336
Benoxaprofen is a potent and long-acting anti-inflammatory and antipyretic compound. Its anti-inflammatory activity has been demonstrated in carrageenan-induced oedema, in cellulose pellet granuloma and in both developing and established adjuvant art
Publikováno v:
Agents and Actions. 9:553-559
A delayed hypersensitivity (DH) reaction is induced by a sensitizing intradermal injection of methylated bovine serum albumin (MBSA) into the abdomen of mice and a subsequent challenge injection of MBSA into the hind paw. Paw volume increase is measu
Publikováno v:
Agents and Actions. 15:569-577
Tenoxicam, a new non-steroidal anti-inflammatory drug has been compared with piroxicam and indomethacin in a range of pharmacological and biochemical inflammation test systems. In a chronic (17-day) adjuvant arthritis in the rat, tenoxicam and piroxi
Autor:
C. H. Cashin, Christine E. Heading
Publikováno v:
British Journal of Pharmacology. 34:148-158
1. A simple, cheap, and reliable method is described for the screening of new compounds for anti-pyretic activity. It involves the intracerebral injection of a suitable pyretogenin in conscious mice.2. The pyretic response is related to the logarithm