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A novel U-STAT3-dependent mechanism mediates the deleterious effects of chronic nicotine exposure on renal injury

Autor: Samira C. Grifoni, Kiran Chandrashekar, Dustin K. Reed, Istvan Arany, Luis A. Juncos, George W. Booz

Publikováno v: American Journal of Physiology-Renal Physiology. 302:F722-F729

Previous data from our group have demonstrated (Arany I, Grifoni S, Clark JS, Csongradi, Maric C, Juncos LA. Am J Physiol Renal Physiol 301: F125–F133, 2011) that chronic nicotine (NIC) exposure exacerbates acute renal ischemic injury (AKI) in mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff90457841fe3e76a0593a693be3b7a1
https://doi.org/10.1152/ajprenal.00338.2011

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Renal inflammation and elevated blood pressure in a mouse model of reduced β-ENaC

Autor: Monette Gousset, David E. Stec, John Michael Barnard, Rumbidayzi Chiposi, Beau Murphey, Heather A. Drummond, Ahmed Abu-Zaid, Samira C. Grifoni

Publikováno v: American Journal of Physiology-Renal Physiology. 301:F443-F449

Previous studies suggest β-epithelial Na+channel protein (β-ENaC) may mediate myogenic constriction, a mechanism of blood flow autoregulation. A recent study demonstrated that mice with reduced levels of β-ENaC (β-ENaC m/m) have delayed correctio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee884dd500d9b0c19cda29b8cc3460d
https://doi.org/10.1152/ajprenal.00694.2010

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Tumor Necrosis Factor-α Antagonist Etanercept Decreases Blood Pressure and Protects the Kidney in a Mouse Model of Systemic Lupus Erythematosus

Autor: Christine Maric, Babbette B Lamarca, Marcia Venegas-Pont, Lorraine C. Racusen, Porter H. Glover, Michael J. Ryan, Allison V. Jones, Michaele B. Manigrasso, Samira C. Grifoni, Heather A. Drummond

Publikováno v: Hypertension. 56:643-649

Chronic inflammation has been implicated in the pathology of hypertension; however, the role for specific cytokines remains unclear. We tested whether tumor necrosis factor-α blockade with etanercept (Etan) reduces mean arterial pressure in a female

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17eb55f115850635ac268494bfb14a8
https://doi.org/10.1161/hypertensionaha.110.157685

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Sensing Tension

Autor: Samira C. Grifoni, Heather A. Drummond, Nikki L. Jernigan

Publikováno v: Hypertension. 51:1265-1271

The epithelial sodium (Na+) channel (ENaC) plays a critical role in blood pressure regulation by controlling renal salt and water reabsorption. Channel overactivity can lead to severe hypertension and underactivity to salt wasting and hypotension.1 I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a669bbbeb75f1b2e75440cd38df8ed48
https://doi.org/10.1161/hypertensionaha.107.093401

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Hsc70 regulates cell surface ASIC2 expression and vascular smooth muscle cell migration

Autor: Heather A. Drummond, Samira C. Grifoni, Susan E. McKey

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 294:H2022-H2030

Recent studies suggest members of the degenerin (DEG)/epithelial Na+channel (ENaC)/acid-sensing ion channel (ASIC) protein family play an important role in vascular smooth muscle cell (VSMC) migration. In a previous investigation, we found suppressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32795bfa7ec240f23833a06670db1b9
https://doi.org/10.1152/ajpheart.01271.2007

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Impaired pressure-induced constriction in mouse middle cerebral arteries of ASIC2 knockout mice

Autor: Samira C. Grifoni, Kimberly P. Gannon, Gina Hamilton, Lauren G VanLandingham, Nikki L. Jernigan, Heather A. Drummond

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 294:H1793-H1803

Recent studies from our laboratory demonstrated the importance of mechanosensitive epithelial Na+channel (ENaC) proteins in pressure-induced constriction in renal and cerebral arteries. ENaC proteins are closely related to acid-sensing ion channel 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fa0a4231a91828ebe231043ac48b0a
https://doi.org/10.1152/ajpheart.01380.2007

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A New Trick for an Old Dogma: ENaC Proteins as Mechanotransducers in Vascular Smooth Muscle

Autor: Heather A. Drummond, Nikki L. Jernigan, Samira C. Grifoni

Publikováno v: Physiology. 23:23-31

Myogenic constriction is a vasoconstriction of blood vessels to increases in perfusion pressure. In renal preglomerular vasculature, it is an established mechanism of renal blood flow autoregulation. Recently, myogenic constriction has been identifie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e11f9abac5b571aa109760464410172
https://doi.org/10.1152/physiol.00034.2007

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ENaC proteins contribute to VSMC migration

Autor: Heather A. Drummond, David E. Stec, Kimberly Anita Gannon, Samira C. Grifoni

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 291:H3076-H3086

Vascular smooth muscle cell (VSMC) migration plays a key role in tissue repair after arterial wall injury. VSMC migration requires integration of chemical and mechanical signaling mechanisms. Recently, we showed that epithelial Na+channel (ENaC) prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8c17939464bca9f8479e019a79127d
https://doi.org/10.1152/ajpheart.00333.2006

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