Zobrazeno 1 - 10
of 141
pro vyhledávání: '"C. Graffner"'
Publikováno v:
Journal of Pharmacy and Pharmacology. 54:499-508
The aim of this in-vivo perfusion study in humans was to investigate the influence of a penetration enhancer, sodium caprate, on the rectal absorption of phenoxymethylpenicillin and antipyrine. Six subjects, 3 male and 3 female, were included in two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b262a1accf7f23efbc1f9678d7a3541c
https://doi.org/10.1211/0022357021778772
https://doi.org/10.1211/0022357021778772
Publikováno v:
Drug Development and Industrial Pharmacy. 24:203-212
The study was designed to optimize the effects of the screened in vitro dissolution variables agitation, temperature, osmolality, and polarity on the release of the neuroleptic compound remoxipride from extended release coated spheres. The variables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813257c3318538a051b4afe118ed85a4
https://doi.org/10.3109/03639049809085611
https://doi.org/10.3109/03639049809085611
Publikováno v:
Drug Development and Industrial Pharmacy. 23:749-760
Different compositions of in vitro dissolution fluids have been developed and used in screening experiments during the development of ethylcellulose ER-coated spheres of the model drug remoxipride. The composititons were different with respect to pH,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b788920ad6dadbbb1cc47fa8acab19b
https://doi.org/10.3109/03639049709150546
https://doi.org/10.3109/03639049709150546
Publikováno v:
European Journal of Pharmaceutical Sciences. 4:73-83
A statistical experimental design was chosen for comparing the in vitro release properties of ethyl cellulose-coated extended release spheres with remoxipride. Two compositions with different plasticizer were tested since these were shown to cause si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::425f229a3b114084b758e2b77d0598cc
https://doi.org/10.1016/0928-0987(95)00033-x
https://doi.org/10.1016/0928-0987(95)00033-x
Publikováno v:
British journal of clinical pharmacology. 48(3)
Changes in drug delivery rate may result in clinically important changes in drug effects. For the loop diuretic frusemide, it would be desirable to develop controlled release preparations, that could maintain an effective urinary excretion rate over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1cd980949ca8cce4930210069ff29b9a
https://pubmed.ncbi.nlm.nih.gov/10510147
https://pubmed.ncbi.nlm.nih.gov/10510147
Publikováno v:
Drug development and industrial pharmacy. 24(4)
The main aims of the present study were to establish an in vitro/in vivo correlation for multiple-unit capsules of paracetamol by means of statistical prediction models and to investigate the effect of a number of in vitro variables on the discussion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aaedd8838a7fa618f7d27afccdb5565
https://pubmed.ncbi.nlm.nih.gov/9876598
https://pubmed.ncbi.nlm.nih.gov/9876598
Publikováno v:
Pharmaceutical research. 10(7)
Remoxipride, a D2-dopamine receptor antagonist, is well tolerated and completely absorbed after oral administration. Because of its extremely bitter taste, an oral palatable suspension was developed by using a taste-masking microencapsulation. The bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee24047c30a3e1d65e4a68c9397d32b0
https://pubmed.ncbi.nlm.nih.gov/8378244
https://pubmed.ncbi.nlm.nih.gov/8378244
Autor:
K, Dyvik, C, Graffner
Publikováno v:
Acta pharmaceutica Nordica. 4(2)
The applicability of a tensile testing machine (M30K, JJ Lloyd Instruments Ltd, GB) is investigated for measuring mucoadhesive strengths. A sample of an aqueous dispersion of a polymer with expected mucoadhesive properties is placed between two homem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ea74f25ed90591acd06a7623b7896f27
https://pubmed.ncbi.nlm.nih.gov/1388773
https://pubmed.ncbi.nlm.nih.gov/1388773
Publikováno v:
Acta pharmaceutica Nordica. 4(1)
The simplex centroid design was applied to the optimization of a modified release tablet formulation. A base granulation was made with the active ingredient naftidrofuryl. The variables investigated included fractions of the excipients microcrystalli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ede1ac742eab9eddceb362a1942615b
https://pubmed.ncbi.nlm.nih.gov/1515056
https://pubmed.ncbi.nlm.nih.gov/1515056
Publikováno v:
Pharmaceutical research. 7(1)
To explore the oral absorption of remoxipride, spheres of remoxipride were labeled with indium-111 colloid before coating with a release-controlling ethylcellulose membrane. Since the labeling remained inside the coating, it was suitable as a marker.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ea24d1a172173e8f2ac64a0f4b584d1
https://pubmed.ncbi.nlm.nih.gov/2137217
https://pubmed.ncbi.nlm.nih.gov/2137217