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Akademický článek

Bacteriome and Mycobiome Interactions Underscore Microbial Dysbiosis in Familial Crohn’s Disease

Autor: G. Hoarau, P. K. Mukherjee, C. Gower-Rousseau, C. Hager, J. Chandra, M. A. Retuerto, C. Neut, S. Vermeire, J. Clemente, J. F. Colombel, H. Fujioka, D. Poulain, B. Sendid, M. A. Ghannoum

Publikováno v: mBio, Vol 7, Iss 5 (2016)

ABSTRACT Crohn’s disease (CD) results from a complex interplay between host genetic factors and endogenous microbial communities. In the current study, we used Ion Torrent sequencing to characterize the gut bacterial microbiota (bacteriome) and fun

Externí odkaz: https://doaj.org/article/e2d6dd58704241b9aac03882a800ee25

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Akademický článek

Respiratory SARS-CoV-2 Infection Causes Skeletal Muscle Atrophy and Long-Lasting Energy Metabolism Suppression

Autor: Sachiko T. Homma, Xingyu Wang, Justin J. Frere, Adam C. Gower, Jingsong Zhou, Jean K. Lim, Benjamin R. tenOever, Lan Zhou

Publikováno v: Biomedicines, Vol 12, Iss 7, p 1443 (2024)

Muscle fatigue represents the most prevalent symptom of long-term COVID, with elusive pathogenic mechanisms. We performed a longitudinal study to characterize histopathological and transcriptional changes in skeletal muscle in a hamster model of resp

Externí odkaz: https://doaj.org/article/75ddaa28d7c4458b8ac017ea6241bab5

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Akademický článek

Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airways

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Abstract SARS-CoV-2 infection and disease severity are influenced by viral entry (VE) gene expression patterns in the airway epithelium. The similarities and differences of VE gene expression (ACE2, TMPRSS2, and CTSL) across nasal and bronchial compa

Externí odkaz: https://doaj.org/article/ba234dab333940e49f16b1217758cc45

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Protectin DX as a therapeutic strategy against frailty in mice

Autor: Laís R. Perazza, Adam C. Gower, Holly M. Brown-Borg, Paola Divieti Pajevic, LaDora V. Thompson

Publikováno v: GeroScience.

Frailty in aging is driven by the dysregulation of multiple biological pathways. Protectin DX (PDX) is a docosahexaenoic acid (DHA)-derived molecule that alleviates many chronic inflammatory disorders, but its potential effects on frailty remain unkn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7acc55025fa502984d55fbf9e66d6126
https://doi.org/10.1007/s11357-023-00789-3

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