Zobrazeno 1 - 10
of 104
pro vyhledávání: '"C. Gopi Mohan"'
Autor:
P. Catherene Tomy, C. Gopi Mohan
Publikováno v:
Artificial Intelligence Chemistry, Vol 1, Iss 2, Pp 100012- (2023)
Monoamine Oxidase-B (MAO-B) is a key neuroprotective target that breaks neurotransmitters such as dopamine and releases highly reactive free radicals as the by-product. Its over-expression in the brain observed due to ageing and neurodegenerative dis
Externí odkaz:
https://doaj.org/article/2820ca4de2824fa687ffc57153b97c5a
Autor:
Bobby D. Robinson, Claire L. Isbell, Anu R. Melge, Angela M. Lomas, Chinchusha Anasooya Shaji, C. Gopi Mohan, Jason H. Huang, Binu Tharakan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The main objective of this study was to determine the cellular and molecular effects of doxycycline on the blood–brain barrier (BBB) and protection against secondary injuries following traumatic brain injury (TBI). Microvascular hyperperme
Externí odkaz:
https://doaj.org/article/2356e89712b944149e98f1ef54b49734
Publikováno v:
Journal of Advanced Research, Vol 7, Iss 6, Pp 931-944 (2016)
Limited progress has been made in the quest to identify both selective and non-toxic T-type calcium channel blocking compounds. The present research work was directed toward slaking the same by identifying the selective three dimensional (3D) pharmac
Externí odkaz:
https://doaj.org/article/ca421cb7ea55408ca625516cbf13c1c2
Publikováno v:
Molecular Informatics.
Publikováno v:
Journal of Chemical Information and Modeling. 62:1126-1146
Autor:
G. Dhamodharan, C. Gopi Mohan
Publikováno v:
Molecular Diversity. 26:1501-1517
Multi-target directed ligand-based 2D-QSAR models were developed using different N-benzyl piperidine derivatives showing inhibitory activity toward acetylcholinesterase (AChE) and β-Site amyloid precursor protein cleaving enzyme (BACE1). Five differ
Autor:
C. Gopi Mohan, Prajeesh Nath En, Anu R. Melge, Anju Choorakottayil Pushkaran, Rammanohar Puthiyedath
Publikováno v:
RSC Advances. 11:12003-12014
Identifying best bioactive phytochemicals from different medicinal plants using molecular docking techniques demonstrates a potential pre-clinical compound discovery against SARS-CoV-2 viral infection. The in silico screening of bioactive phytochemic
Autor:
C. Gopi Mohan, Lakshmi Sumitra Vijayachandran, Serene Xavier, Shantikumar V. Nair, Krishnakumar N. Menon
Publikováno v:
International Journal of Biological Macromolecules. 124:17-24
Epidermal growth factor receptor variant III (EGFRvIII) is known to be specifically expressed in cancer cells and associated with tumor virulence. The receptor provides an opportunity for both specifically targeting the tumor cells as well as for pot
Autor:
Anu R. Melge, C Gopi Mohan, K. Manzoor, Lekshmi G. Kumar, Keechilat Pavithran, Shantikumar V. Nair
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 37:4747-4766
BCR-ABL fusion protein drives chronic myeloid leukemia (CML) which constitutively activates tyrosine kinase involved in the initiation and maintenance of CML phenotype. Ponatinib, an oral drug, was discovered as an efficient BCR-ABL inhibitor by addr
Autor:
Anju Choorakottayil Pushkaran, Prajeesh Nath EN, Shantikumar V Nair, Rammanohar P, C Gopi Mohan
The present COVID-19 global crisis invoked different disciplines of the biomedical research community to address the contagious human to human viral transmission and infection severity. Traditional or de novo drug discovery approach is a very time co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e34e157a3af8cc135c2479d62c7273
https://doi.org/10.26434/chemrxiv.13127240.v1
https://doi.org/10.26434/chemrxiv.13127240.v1