Zobrazeno 1 - 10
of 918
pro vyhledávání: '"C. Gobe"'
Autor:
David A. Vesey, Abishek Iyer, Evan Owen, Danielle Kamato, David W. Johnson, Glenda C. Gobe, David P. Fairlie, David J. Nikolic-Paterson
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Key features of chronic kidney disease (CKD) include tubulointerstitial inflammation and fibrosis. Protease activated receptor-2 (PAR2), a G-protein coupled receptor (GPCR) expressed by the kidney proximal tubular cells, induces potent proinflammator
Externí odkaz:
https://doaj.org/article/acd3f424f03c4ce7a40cc0c7435e9fc3
Autor:
Samreen N. Shaikh, Emily F. Willis, Max Dierich, Yi Xu, Samuel J. S. Stuart, Glenda C. Gobe, Abate A. Bashaw, Oliver Rawashdeh, Seung Jae Kim, Jana Vukovic
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-20 (2023)
Abstract Graft-versus-host disease (GVHD) is a serious complication of otherwise curative allogeneic haematopoietic stem cell transplants. Chronic GVHD induces pathological changes in peripheral organs as well as the brain and is a frequent cause of
Externí odkaz:
https://doaj.org/article/99d2dd503b23450b9fb4733adf954daa
Publikováno v:
Current Research in Toxicology, Vol 6, Iss , Pp 100140- (2024)
Background: Urinary cadmium excretion (ECd) rises with renal tissue content of the metal. Whereas glomerulopathies are sometimes associated with massive albuminuria, tubular accumulation of Cd typically causes modest albuminuria. Since β2-microglobu
Externí odkaz:
https://doaj.org/article/8b1f4a3158f14c84bd4af6376e7cfb61
Autor:
Aaron J. Urquhart, Sharon J. Del Vecchio, Darren Lukas, Robert J. Ellis, Tyrone L.R. Humphries, Keng Lim Ng, Hemamali Samaratunga, Graham J. Galloway, Glenda C. Gobe, Simon T. Wood, Carolyn E. Mountford
Publikováno v:
Advances in Biomarker Sciences and Technology, Vol 5, Iss , Pp 68-75 (2023)
Tumor heterogeneity and lack of pre-operative diagnostic biomarkers are key topics in the field of renal cell carcinoma (RCC) identification. Clear cell RCC (ccRCC) is an aggressive cancer subtype which accounts for most RCC related deaths. The capac
Externí odkaz:
https://doaj.org/article/aa8d849370604032987f8f16024175cb
Publikováno v:
Stresses, Vol 2, Iss 3, Pp 355-372 (2022)
Cadmium (Cd) is an environmental toxicant of public health significance worldwide. Diet is the main Cd exposure source in the non-occupationally exposed and non-smoking populations. Metal transporters for iron (Fe), zinc (Zn), calcium (Ca), and manga
Externí odkaz:
https://doaj.org/article/caa654848c1c4cb5806ec75f1f225f09
Autor:
Soisungwan Satarug, David A. Vesey, Tanaporn Khamphaya, Phisit Pouyfung, Glenda C. Gobe, Supabhorn Yimthiang
Publikováno v:
Toxics, Vol 11, Iss 9, p 755 (2023)
Cadmium (Cd) is a pervasive, toxic environmental pollutant that preferentially accumulates in the tubular epithelium of the kidney. Current evidence suggests that the cumulative burden of Cd here leads to the progressive loss of the glomerular filtra
Externí odkaz:
https://doaj.org/article/41c1ce2f916443f688abc42e08b8ceda
Autor:
Supabhorn Yimthiang, David A. Vesey, Glenda C. Gobe, Phisit Pouyfung, Tanaporn Khamphaya, Soisungwan Satarug
Publikováno v:
Toxics, Vol 11, Iss 7, p 616 (2023)
The excretion of β2-microglobulin (β2M) above 300 µg/g creatinine, termed tubulopathy, was regarded as the critical effect of chronic exposure to the metal pollutant cadmium (Cd). However, current evidence suggests that Cd may induce nephron atrop
Externí odkaz:
https://doaj.org/article/94aeedf247af46faaae4cdb47b7ff84c
Autor:
Supabhorn Yimthiang, Phisit Pouyfung, Tanaporn Khamphaya, David A. Vesey, Glenda C. Gobe, Soisungwan Satarug
Publikováno v:
Toxics, Vol 11, Iss 6, p 516 (2023)
The most common causes of chronic kidney disease, diabetes, and hypertension are significant public health issues worldwide. Exposure to the heavy metal pollutant, cadmium (Cd), which is particularly damaging to the kidney, has been associated with b
Externí odkaz:
https://doaj.org/article/7953ea5747554bae93ef681e4eaaa880
Autor:
Muhammad Shoaib Zafar, Khadija Shahid, Glenda C. Gobe, Riffat Yasmin, Nadia Naseem, Muhammad Shahzad
Publikováno v:
Journal of King Saud University: Science, Vol 34, Iss 3, Pp 101877- (2022)
Objectives: Pregsal is a novel salicylaldehyde derivative of pregabalin, a structural analogue of gamma-aminobutyric acid approved for treating epilepsy, neuropathic pain and diabetic peripheral neuropathy but not trialled to date for airway inflamma
Externí odkaz:
https://doaj.org/article/06d65492a0dc4149806bc02615ff3f73
Autor:
Muhammad Ali Khan MPharm, Andrew J Kassianos PhD, Wendy E Hoy MD, AHM Khurshid Alam PhD, Helen G Healy MD, Glenda C Gobe PhD
Publikováno v:
Journal of Evidence-Based Integrative Medicine, Vol 27 (2022)
Chronic kidney disease (CKD) is debilitating, increasing in incidence worldwide, and a financial and social burden on health systems. Kidney failure, the final stage of CKD, is life-threatening if untreated with kidney replacement therapies. Current
Externí odkaz:
https://doaj.org/article/8587d04c760d41e09036ccbf4d5747d4