Výsledky vyhledávání

The NMR structure of 31mer RNA domain of Escherichia coli RNase P RNA using its non-uniformly deuterium labelled counterpart [the 'NMR- window' concept]

Autor: András Földesi, Jyoti Chattopadhyaya, C. Glemarec, Leif A. Kirsebom, Tatiana Maltseva, A. Sandström, J Kufel

Publikováno v: Nucleic Acids Research. 24:2022-2035

The NMR structure of a 31mer RNA constituting a functionally important domain of the catalytic RNase P RNA from Escherichia coli is reported. Severe spectral overlaps of the proton resonances in the natural 31mer RNA (1) were successfully tackled by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03050ca53633b9cc26c9f0dcefa6e50c
https://doi.org/10.1093/nar/24.11.2022

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Synthetic and conformational studies of branched and lariat RNAs. Modelling the lariat formed in the splicing reaction — A critical review

Autor: C. Glemarec, Christian Sund, Jyoti Chattopadhyaya

Publikováno v: Proceedings / Indian Academy of Sciences. 106:1023-1050

The formation of lariat RNAs in eukaryotes plays a central role in the transmission of genetic information into protein products through the synthesis of the processed RNA. The biomimetic synthetic models (branched and lariat RNAs) of the lariat RNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b30f81aeb342b5d8e7905fc3d57043a
https://doi.org/10.1007/bf02841915

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Solution conformation of hexameric & heptameric lariat-RNAs and their self-cleavage reactions which give products mimicking those from some catalytic RNAs (ribozymes)

Autor: Nitin Puri, P. Agback, Jyoti Chattopadhyaya, Bertrand Rousse, A. Sandström, G. Viswanadham, Christian Sund, C. Glemarec

Publikováno v: Tetrahedron. 50:1777-1810

The small "lariot" hexameric 1 and hepromeric 2 RNAs undergo selfcleovoge. whereas Ihe two cyclic A(2'+553G and A(3'-tS*)G linked teframers 3 and 4 do not self-cleave. The site of phosphodiester cleovagc is specific and occurs ot the 3'-phosphate of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e61d763f37c4bdc5267f6d10a2933765
https://doi.org/10.1016/s0040-4020(01)80852-8

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Remarkable conformational change promoted by 3′-ethylphosphate at the branch-point of a tetrameric lariat-RNA dictates its self-cleavage reaction modelling some catalytic RNAs (ribozymes)

Autor: Christian Sund, C. Glemarec, Bertrand Rousse, Jyoti Chattopadhyaya, A. Sandström, P. Agback

Publikováno v: Tetrahedron. 50:8711-8736

Small synthetic lariat RNAs have ken found to undergo site specific self-cleavage to give an acyclic branched-RNA with 2'3'~cyclic phosphate and a S-hydroxyl termird, which is reminiscent of tk products formed in some catalytic RNAs. These lariat-RNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eec2e9b897a0e98c6acd12bf2b291852
https://doi.org/10.1016/s0040-4020(01)85346-1

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Solution structure of lariat RNA by 500 MHz NMR spectroscopy and molecular dynamics studies in water

Autor: Christian Sund, A. Sandström, Jyoti Chattopadhyaya, S.-I. Yamakage, C. Glemarec, P. Agback

Publikováno v: Journal of Biochemical and Biophysical Methods. 27:229-259

Summary A 500 MHz NMR study of the lariat RNA tetramer 1 and pentamer 2 mimicking the naturally occurring lariat RNA is reported. The conformational properties of 1 and 2 were compared with those of a linear branched RNA tetramer 3, which show that t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82398d686a13811bd7329b2c124524e5
https://doi.org/10.1016/0165-022x(93)90006-a

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Synthesis of 2′,3′-cis-fused pyrrolidino-β-D-nucleosides and their conformational analysis by 500 MHz 1H-NMR

Autor: C. Glemarec, Zhen Xi, Jyoti Chattopadhyaya

Publikováno v: Tetrahedron. 49:7525-7546

The unique “off-template” stereoselectivity in the intramolecular free radical cyclization of 3-aza-5-hexenyl endocyclic radical has been demonstrated for the first time through the synthesis of 2′,3′- cis-fused pyrrolidino-β-D-nucleosides,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adec5c395b173ece62b30ca69aab29f6
https://doi.org/10.1016/s0040-4020(01)87228-8

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The self-cleavage of lariat-RNA

Autor: Bertrand Rousse, S.-I. Yamakage, C. Glemarec, Lee Yin, Nitin Puri, Jyoti Chattopadhyaya, J. Plavec, A. Sandström, Garimella Viswanadham, Christian Sund, P. Agback

Publikováno v: Tetrahedron Letters. 34:3929-3932

Lariat-RNAs 3 and 4 undergo site-specific self-cleavage reaction at the G 3 → C 6 /U 7 phosphodiester bond by the nucleophilic attack of 2′-OH of G 3 sugar moiety to its 3′-phosphate to give 5′-hydroxyl terminal at C 6 or U 7 and 2′,3′-cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::273ce504ff9f8883b7f6992ee5d37e8d
https://doi.org/10.1016/s0040-4039(00)79266-5

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NMR spectroscopic properties (1H at 500 MHz) of deuterated∗ ribonucleotide-dimers ApU∗, GpC∗, partially deuterated 2′-deoxyribonucleotide-dimers d(TpA∗, d(ApT∗, d(GpC∗ and their comparison with natural counterparts (1H-NMR window)

Autor: András Földesi, Jyoti Chattopadhyaya, C. Glemarec, F. P. R. Nilson, C. Gioeli

Publikováno v: Journal of Biochemical and Biophysical Methods. 26:1-26

Pure 1'#,2',3',4'#,5',5''-2H6-ribonucleoside derivatives 10-14, 1'#,2',2'',3',4'#,5',5''-2H7-2'-deoxynucleoside blocks 15-18 and their natural-abundance counterparts were used to assemble partially deuterated ribonucleotide-dimers (* indicates deuter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9feca79e6b8e4b89579fdc4419d9ac2b
https://doi.org/10.1016/0165-022x(93)90018-j

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