Zobrazeno 1 - 10
of 181
pro vyhledávání: '"C. Glazer"'
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 441 (2024)
While cytochrome P450 (CYP; P450) enzymes are commonly associated with the metabolism of organic xenobiotics and drugs or the biosynthesis of organic signaling molecules, they are also impacted by a variety of inorganic species. Metallic nanoparticle
Externí odkaz:
https://doaj.org/article/99b43ae924fb416c8e772d6c78c0ba54
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
The cytochrome P450 enzyme CYP1B1 is overexpressed in a variety of tumors, and is correlated with poor treatment outcomes; thus, it is desirable to develop CYP1B1 inhibitors to restore chemotherapy efficacy. Here the authors describe the creation of
Externí odkaz:
https://doaj.org/article/cd3c1b4728124a4f8e73b7f958ed2e00
Publikováno v:
ACS Omega, Vol 5, Iss 30, Pp 18894-18906 (2020)
Externí odkaz:
https://doaj.org/article/ccf0ba56740943c99b14baaf8f4ffd67
Autor:
Richard J. Mitchell, Sarah M. Kriger, Alexander D. Fenton, Dmytro Havrylyuk, Ankit Pandeya, Yang Sun, Tami Smith, Jason E. DeRouchey, Jason M. Unrine, Viral Oza, Jessica S. Blackburn, Yinan Wei, David K. Heidary, Edith C. Glazer
Publikováno v:
RSC Chemical Biology. 4:344-353
Phenanthriplatin forms DNA mono-adducts and induces ribosome biogenesis stress. Using a semi-rational strategy, Ru(ii) complexes were created that act as biological mimics of phenanthriplatin with improved properties.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d858fd26c8b8445e3028892a060bcf52
https://doi.org/10.1039/d2cb00247g
https://doi.org/10.1039/d2cb00247g
Publikováno v:
Journal of Medicinal Chemistry. 66:398-412
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc3d727591fb13105e8320f10b1e41f7
https://doi.org/10.1021/acs.jmedchem.2c01368
https://doi.org/10.1021/acs.jmedchem.2c01368
Autor:
Stephen H. Poor, Georges Weissgerber, Christopher M. Adams, Harit Bhatt, David J. Browning, James Chastain, Thomas A. Ciulla, Michael Ferriere, Kinfemichael Gedif, Louis C. Glazer, Brian C. Joondeph, Guillaume Normand, Veeral Sheth, Christie Watters, Cynthia L. Grosskreutz
Publikováno v:
American Journal of Ophthalmology. 239:180-189
To evaluate whether topical acrizanib (LHA510), a small-molecule vascular endothelial growth factor receptor inhibitor, could suppress the need for anti-vascular endothelial growth factor therapy over a 12-week period in patients with neovascular age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19367ce37551cd725bf81ee513cc549
https://doi.org/10.1016/j.ajo.2022.02.019
https://doi.org/10.1016/j.ajo.2022.02.019
Autor:
Jeffrey D. Cain, Alex Zettl, Marvin L. Cohen, Kyunghoon Lee, Mehmet Dogan, Wu Shi, Emily C. Glazer, Xuanze Yu, Amin Azizi
Publikováno v:
ACS Nano. 15:18297-18304
Metallic transition-metal dichalcogenides (TMDs) are rich material systems in which the interplay between strong electron–electron and electron–phonon interactions often results in a variety of col...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::166a356c4338ed4c7f1d59446ab76e2b
https://doi.org/10.1021/acsnano.1c07526
https://doi.org/10.1021/acsnano.1c07526
Autor:
Dmytro Havrylyuk, David K. Heidary, Kimberly C. Stevens, Sean Parkin, L. Henry Moore, Raphael T. Ryan, John P. Selegue, Jessica S. Blackburn, Edith C. Glazer
Publikováno v:
Eur J Inorg Chem
The β-diketone scaffold is a commonly used synthetic intermediate, and is a functional group found in natural products such as curcuminoids. This core structure can also act as a chelating ligand for a variety of metals. In order to assess the poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9321d3a6751daaa0087df69fcf6219aa
https://doi.org/10.1002/ejic.202100468
https://doi.org/10.1002/ejic.202100468
Publikováno v:
ChemMedChem
Inhibition of estrogen synthesis is an integral component of the frontline pharmacologic therapy for the treatment of estrogen receptor positive cancers. However, there is currently no direct, high-throughput-ready assay for aromatase (also known as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c994635e5d4170258d9efd321edcf5
https://doi.org/10.1002/cmdc.202100326
https://doi.org/10.1002/cmdc.202100326
Autor:
Raphael T. Ryan, Austin C. Hachey, Kimberly Stevens, Sean R. Parkin, Richard J. Mitchell, John P. Selegue, David K. Heidary, Edith C. Glazer
Publikováno v:
Journal of inorganic biochemistry. 238
Photoreactive Ru(II) complexes capable of ejecting ligands have been used extensively for photocaging applications and for the creation of "photocisplatin" reagents. The incorporation of distortion into the structure of the coordination complex lower
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d8eef41544ddd45331461e968aeebe
https://pubmed.ncbi.nlm.nih.gov/36327501
https://pubmed.ncbi.nlm.nih.gov/36327501