Zobrazeno 1 - 10
of 193
pro vyhledávání: '"C. Giovanella"'
Publikováno v:
International Journal of Nanomedicine. 14:3799-3817
Background and aim: We have synthesized a novel lactone-stabilized camptothecin (CPT) analog named CZ48 and demonstrated its potent anticancer effects via bioconversion to the active CPT in earlier studies. Herein, we aimed to develop, optimize and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3781256b05904b9d225b8680809d977f
https://doi.org/10.2147/ijn.s196453
https://doi.org/10.2147/ijn.s196453
Akademický článek
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Autor:
Emily H. Griffith, Kim Williams, Shelly L. Vaden, Peter J Early, C. Giovanella, Lindsay Boozer, Karen R. Muñana, Christopher L. Mariani, R. Longshore, Natasha J. Olby, Tonya Harris, Simon R. Platt
Publikováno v:
Journal of Veterinary Internal Medicine
Background Dogs with spinal cord injury are at increased risk of developing bacteriuria due to increased residual urine volume. Cranberry extract inhibits binding of E. coli to uroepithelial cells, potentially reducing risk of bacteriuria. Hypothesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8ac449aae89ab8d32b7577f14d1fbd
http://europepmc.org/articles/PMC5259620
http://europepmc.org/articles/PMC5259620
Autor:
Natasha J. Olby, Audrey C. Muguet-Chanoit, Marie Davidian, C. Giovanella, R. Longshore, J. Humphrey, Ji-Hey Lim, Karen R. Muñana, S. R. Platt, Christopher L. Mariani, Peter J Early, A.C. Freeman, Marc Kent
Publikováno v:
Journal of Veterinary Internal Medicine
Background Acute intervertebral disk herniation (IVDH) is a common cause of spinal cord injury in dogs and currently there is no proven medical treatment to counter secondary injury effects. Use of methylprednisolone sodium succinate (MPSS) or polyet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c3bb87727cb89495e7f33d30a64cc9
https://doi.org/10.1111/jvim.13657
https://doi.org/10.1111/jvim.13657
Autor:
Douglas R. Coil, John Mendoza, Dana Vardeman, Beppino C. Giovanella, Constantine S.A. Markides, Tony Kozielski, Linh H. Luong
Publikováno v:
Oncology Letters
Desmoplastic small round cell tumor (DSRCT) is an extremely rare and aggressive neoplasm, which mainly affects young males and generally presents as a widely disseminated tumor within the peritoneal cavity. Due to the rarity of the tumor, its younger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0cac116578d1c743d620a9cbc34bc4
http://europepmc.org/articles/PMC3678573
http://europepmc.org/articles/PMC3678573
Publikováno v:
Biomedical Reports. 1:202-206
Crystalline camptothecin-20-O-propionate hydrate (CZ48) is an esterification product from the reaction of natural camptothecin with propionic anhydride. CZ48 has been tested against 29 human tumor lines grown in nude mice as xenografts. Of the tested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71fb92f7a8d42e6e5818989791d92d5
https://doi.org/10.3892/br.2013.55
https://doi.org/10.3892/br.2013.55
Autor:
Beppino C. Giovanella, Xing Liu, Dana Vardeman, A. J. Kozielski, Zhisong Cao, Yang Wang, Chang-Guo Zhan, Albert DeJesus, John Mendoza
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 12:818-828
All chemotherapeutic agents currently in use have a narrow window of therapeutic index of 1 to 1.2. Camptothecin ester compounds are reported to have a wider therapeutic index when being used to treat human xenografts in nude mice. As a continuous ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d394d5ac2ce7a076cda05f8405afe0c
https://doi.org/10.2174/187152012802650219
https://doi.org/10.2174/187152012802650219
Publikováno v:
Open Journal of Medicinal Chemistry. :10-14
Camptothecin-20-propinate (CZ48) and other camptothecin ester derivatives were prepared by the esterification reac-tions of camptothecin or 9-nitrocamptothecin with the corresponding acylating agents such as organic acid anhydride or chloride with co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1bc9dd0c81d9f550d3d61e07c51606c
https://doi.org/10.4236/ojmc.2012.21002
https://doi.org/10.4236/ojmc.2012.21002
Publikováno v:
Acta Pathologica Microbiologica Scandinavica Series A :Pathology. :133-147
Five new small cell carcinomas (SCC) cell lines and a large cell carcinoma (LCC) cell line were established from human lung cancers. The SCC cell lines had, as a group, common phenotypic properties which distinguished them from non-SCC cell lines. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6f23eaac7b70c8f42c14a309e13da8
https://doi.org/10.1111/j.1699-0463.1985.tb03932.x
https://doi.org/10.1111/j.1699-0463.1985.tb03932.x
Publikováno v:
Cancer Research. 69:4742-4749
To find a more effective and less toxic chemotherapeutic agent, we have successfully prepared crystalline camptothecin-20(S)-O-propionate hydrate (CZ48) by reacting camptothecin with propionic anhydride using concentrated sulfuric acid as catalyst. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc452f460143431da4a4e9eb399561a1
https://doi.org/10.1158/0008-5472.can-08-4452
https://doi.org/10.1158/0008-5472.can-08-4452