Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus

Autor: Adrienne Tin, Pascal Schlosser, Pamela R. Matias-Garcia, Chris H. L. Thio, Roby Joehanes, Hongbo Liu, Zhi Yu, Antoine Weihs, Anselm Hoppmann, Franziska Grundner-Culemann, Josine L. Min, Victoria L. Halperin Kuhns, Adebowale A. Adeyemo, Charles Agyemang, Johan Ärnlöv, Nasir A. Aziz, Andrea Baccarelli, Murielle Bochud, Hermann Brenner, Jan Bressler, Monique M. B. Breteler, Cristian Carmeli, Layal Chaker, Josef Coresh, Tanguy Corre, Adolfo Correa, Simon R. Cox, Graciela E. Delgado, Kai-Uwe Eckardt, Arif B. Ekici, Karlhans Endlich, James S. Floyd, Eliza Fraszczyk, Xu Gao, Xīn Gào, Allan C. Gelber, Mohsen Ghanbari, Sahar Ghasemi, Christian Gieger, Philip Greenland, Megan L. Grove, Sarah E. Harris, Gibran Hemani, Peter Henneman, Christian Herder, Steve Horvath, Lifang Hou, Mikko A. Hurme, Shih-Jen Hwang, Sharon L. R. Kardia, Silva Kasela, Marcus E. Kleber, Wolfgang Koenig, Jaspal S. Kooner, Florian Kronenberg, Brigitte Kühnel, Christine Ladd-Acosta, Terho Lehtimäki, Lars Lind, Dan Liu, Donald M. Lloyd-Jones, Stefan Lorkowski, Ake T. Lu, Riccardo E. Marioni, Winfried März, Daniel L. McCartney, Karlijn A. C. Meeks, Lili Milani, Pashupati P. Mishra, Matthias Nauck, Christoph Nowak, Annette Peters, Holger Prokisch, Bruce M. Psaty, Olli T. Raitakari, Scott M. Ratliff, Alex P. Reiner, Ben Schöttker, Joel Schwartz, Sanaz Sedaghat, Jennifer A. Smith, Nona Sotoodehnia, Hannah R. Stocker, Silvia Stringhini, Johan Sundström, Brenton R. Swenson, Joyce B. J. van Meurs, Jana V. van Vliet-Ostaptchouk, Andrea Venema, Uwe Völker, Juliane Winkelmann, Bruce H. R. Wolffenbuttel, Wei Zhao, Yinan Zheng, The Estonian Biobank Research Team, The Genetics of DNA Methylation Consortium, Marie Loh, Harold Snieder, Melanie Waldenberger, Daniel Levy, Shreeram Akilesh, Owen M. Woodward, Katalin Susztak, Alexander Teumer, Anna Köttgen

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Serum urate concentration can be studied in large datasets to find genetic and epigenetic loci that may be related to cardiometabolic traits. Here the authors identify and replicate 100 urate-associated CpGs, which provide insights into urate GWAS lo

Externí odkaz: https://doaj.org/article/34e5ed6ae9ad4343931586438a0971b4

Smoking is not linked to the development of anti-peptidylarginine deiminase 4 autoantibodies in rheumatoid arthritis

Autor: Laura C. Cappelli, Maximilian F. Konig, Allan C. Gelber, Clifton O. Bingham, Erika Darrah

Publikováno v: Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-8 (2018)

Abstract Background Defining environmental factors responsible for development of autoimmunity in rheumatoid arthritis (RA) is critical for understanding mechanisms of disease initiation and propagation. Notably, a history of cigarette smoking has be

Externí odkaz: https://doaj.org/article/3b5bb0d4d2bb4aae9f5d2836c1399e0f

Hyperuricemia after orthotopic liver transplantation: divergent associations with progression of renal disease, incident end-stage renal disease, and mortality

Autor: Joseph C. Longenecker, Sana Waheed, Ghassan Bandak, Christine A. Murakami, Blaithin A. McMahon, Allan C. Gelber, Mohamed G. Atta

Publikováno v: BMC Nephrology, Vol 18, Iss 1, Pp 1-11 (2017)

Abstract Background Although hyperuricemia is common after orthotopic liver transplantation (OLT), its relationship to mortality, progressive kidney disease, or the development of end stage renal disease (ESRD) is not well-described. Methods Data fro

Externí odkaz: https://doaj.org/article/90d5f7809ea848d2b0cd7f4ec5362771

A Randomized Pilot Study of DASH Patterned Groceries on Serum Urate in Individuals with Gout

Autor: Stephen P. Juraschek, Edgar R. Miller, Beiwen Wu, Karen White, Jeanne Charleston, Allan C. Gelber, Sharan K. Rai, Kathryn A. Carson, Lawrence J. Appel, Hyon K. Choi

Publikováno v: Nutrients, Vol 13, Iss 2, p 538 (2021)

The Dietary Approaches to Stop Hypertension (DASH) diet reduces serum urate (SU); however, the impact of the DASH diet has not been previously evaluated among patients with gout. We conducted a randomized, controlled, crossover pilot study to test th

Externí odkaz: https://doaj.org/article/92b9afd867f7417099e323710068e9c4

Clear and Bright: An Elusive Cause of Hypoxemia

Autor: Diep Edwards, Allan C. Gelber, Rachel Sennett, Jaroslaw Jedrych, Catherine E. Simpson, John A. Wells

Publikováno v: The American journal of medicine.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460444ca7d89e12c4a0244f830f852e3
https://pubmed.ncbi.nlm.nih.gov/36252706