Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau

Autor: Luca Ferrari, Riccardo Stucchi, Katerina Konstantoulea, Gerarda van de Kamp, Renate Kos, Willie J. C. Geerts, Laura S. van Bezouwen, Friedrich G. Förster, Maarten Altelaar, Casper C. Hoogenraad, Stefan G. D. Rüdiger

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Tau fibril formation is a hallmark of Alzheimer’s disease. Here the authors reveal an aggregation-dependent protein interaction pattern of Tau and further show that π-stacking of the arginine side-chains drives aberrant protein binding to Tau fibr

Externí odkaz: https://doaj.org/article/1e2a4433b35f46b3b264a6a1c10869f9

Synovial fluid pretreatment with hyaluronidase facilitates isolation of CD44+ extracellular vesicles

Autor: Janneke Boere, Chris H. A. van de Lest, Sten F. W. M. Libregts, Ger J. A. Arkesteijn, Willie J. C. Geerts, Esther N. M. Nolte-'t Hoen, Jos Malda, P. René van Weeren, Marca H. M. Wauben

Publikováno v: Journal of Extracellular Vesicles, Vol 5, Iss 0, Pp 1-16 (2016)

Extracellular vesicles (EVs) in synovial fluid (SF) are gaining increased recognition as important factors in joint homeostasis, joint regeneration, and as biomarkers of joint disease. A limited number of studies have investigated EVs in SF samples o

Externí odkaz: https://doaj.org/article/787a80c78ad143cf97c76c75cf606ba8

Regional variations in childbirth interventions and their correlations with adverse outcomes, birthplace and care provider: a nationwide explorative study

Autor: Caroline C. Geerts, Anna E Seijmonsbergen-Schermers, Thomas van den Akker, Ank de Jonge, François G. Schellevis, Marianne Nieuwenhuijze, Dirkje C. Zondag, Corine Verhoeven

Publikováno v: PLOS ONE
Seijmonsbergen-Schermers, A E, Zondag, D C, Nieuwenhuijze, M, Van Den Akker, T, Verhoeven, C J, Geerts, C C, Schellevis, F G & De Jonge, A 2020, ' Regional variations in childbirth interventions and their correlations with adverse outcomes, birthplace and care provider : A nationwide explorative study ', PLoS ONE, vol. 15, no. 3, e0229488, pp. 1-20 . https://doi.org/10.1371/journal.pone.0229488
PLoS ONE, 15(3):e0229488. Public Library of Science
Seijmonsbergen-Schermers, A E, Zondag, D C, Nieuwenhuijze, M, van den Akker, T, Verhoeven, C J, Geerts, C C, Schellevis, F G & de Jonge, A 2020, ' Regional variations in childbirth interventions and their correlations with adverse outcomes, birthplace and care provider : A nationwide explorative study ', PLoS ONE, vol. 15, no. 3, e0229488, pp. e0229488 . https://doi.org/10.1371/journal.pone.0229488
PLoS ONE, 15(3):e0229488, 1-20. Public Library of Science
PLoS ONE
PLoS ONE, Vol 15, Iss 3, p e0229488 (2020)

BACKGROUND: Variations in childbirth interventions may indicate inappropriate use. Most variation studies are limited by the lack of adjustments for maternal characteristics and do not investigate variations in adverse outcomes. This study aims to ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac6edecf20fe379d9fdcb30daf23b2a
https://surfsharekit.nl/public/7860c2ef-34ee-4191-83d6-9bd3a09dcd69

Human chaperones untangle fibrils of the Alzheimer protein Tau

Autor: van Wezel M, Luca Ferrari, Stefan G.D. Rüdiger, van Bezouwen Ls, Willie J. C. Geerts, Konstantoulea A, Renate Kos, Friedrich Förster

Alzheimer’s Disease is the most common neurodegenerative disorder. A hallmark of this disease is aggregation of the protein Tau into fibrillar tangles, which is ultimately linked to neuronal death 1,2. Oligomeric precursors of Tau fibrils are suspe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25235df59e05345f946651b5513861a2
https://doi.org/10.1101/426650

Regional variations in childbirth interventions in the Netherlands: A nationwide explorative study

Autor: C. C. Geerts, D. C. Zondag, A. de Jonge, T. van den Akker, François G. Schellevis, Anna E Seijmonsbergen-Schermers, Corine J.M. Verhoeven, Marianne Nieuwenhuijze

Publikováno v: BMC Pregnancy and Childbirth, 18(1):192. BioMed Central
BMC Pregnancy and Childbirth, 18
BMC Pregnancy and Childbirth, Vol 18, Iss 1, Pp 1-18 (2018)
Seijmonsbergen-Schermers, A E, Zondag, D C, Nieuwenhuijze, M, Van den Akker, T, Verhoeven, C J, Geerts, C, Schellevis, F & De Jonge, A 2018, ' Regional variations in childbirth interventions in the Netherlands : A nationwide explorative study ', BMC Pregnancy and Childbirth, vol. 18, no. 1, 192 . https://doi.org/10.1186/s12884-018-1795-0
BMC Pregnancy and Childbirth

Background Although interventions in childbirth are important in order to prevent neonatal and maternal morbidity and mortality, non-indicated use may cause avoidable harm. Regional variations in intervention rates, which cannot be explained by mater

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3742742d914d2f5b717ee228cccf7f41
https://research.vumc.nl/en/publications/dbb3dee5-7f41-4ec2-9147-a87a97e33d77