Zobrazeno 1 - 10
of 112
pro vyhledávání: '"C. Gadaleta"'
Publikováno v:
PLoS Genetics, Vol 13, Iss 9, p e1007013 (2017)
The DNA repair enzyme polynucleotide kinase/phosphatase (PNKP) protects genome integrity by restoring ligatable 5'-phosphate and 3'-hydroxyl termini at single-strand breaks (SSBs). In humans, PNKP mutations underlie the neurological disease known as
Externí odkaz:
https://doaj.org/article/080a3790097c41548754bdb493dc6f6f
Publikováno v:
European Heart Journal Supplements. 24
41 y–o woman, without cardiovascular risk factors, was diagnosed with breast cancer (pT2N1aMx, G3, ER:70%, PgR:30%, HER–2/NEU:2+, Ki67:60%). Treated (2010) with adjuvant antracyclines, taxanes and hormonal therapy. Subsequently, developed (2012)
Akademický článek
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Publikováno v:
BioTechniques, Vol 55, Iss 5, Pp 257-263 (2013)
We describe a series of new vectors for PCR-based epitope tagging and gene disruption in the fission yeast Schizosaccharomyces pombe, an exceptional model organism for the study of cellular processes. The vectors are designed for amplification of gen
Externí odkaz:
https://doaj.org/article/ef1e1bbdf353403e8da07d898a2a6019
Autor:
Mariana C Gadaleta, Mukund M Das, Hideki Tanizawa, Ya-Ting Chang, Ken-ichi Noma, Toru M Nakamura, Eishi Noguchi
Publikováno v:
PLoS Genetics, Vol 12, Iss 3, p e1005943 (2016)
Genomic instability associated with DNA replication stress is linked to cancer and genetic pathologies in humans. If not properly regulated, replication stress, such as fork stalling and collapse, can be induced at natural replication impediments pre
Externí odkaz:
https://doaj.org/article/c6127aa80e8249ceb911268fa59fb26b
Autor:
Mariana C. Gadaleta, Eishi Noguchi
Publikováno v:
Genes, Vol 8, Iss 3, p 98 (2017)
All living organisms need to duplicate their genetic information while protecting it from unwanted mutations, which can lead to genetic disorders and cancer development. Inaccuracies during DNA replication are the major cause of genomic instability,
Externí odkaz:
https://doaj.org/article/8351e27de6d741cf9a97385b4ce672ce
Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress
Autor:
Oliver Limbo, Michael N. Boddy, Mariana C. Gadaleta, Minghua Nie, Martina Oravcová, Paul Russell, Michael C. Reubens
Publikováno v:
Molecular and Cellular Biology. 39
As genetic instability drives disease or loss of cell fitness, cellular safeguards have evolved to protect the genome, especially during sensitive cell cycle phases, such as DNA replication. Fission yeast Brc1 has emerged as a key factor in promoting
Publikováno v:
PLoS Genetics, Vol 13, Iss 9, p e1007013 (2017)
PLoS Genetics
PLoS Genetics
The DNA repair enzyme polynucleotide kinase/phosphatase (PNKP) protects genome integrity by restoring ligatable 5’-phosphate and 3’-hydroxyl termini at single-strand breaks (SSBs). In humans, PNKP mutations underlie the neurological disease known
The DNA repair enzyme polynucleotide kinase/phosphatase (PNKP) protects genome integrity by restoring ligatable 5’-phosphate and 3’-hydroxyl termini at single-strand breaks (SSBs). In humans, PNKP mutations underlie the neurological disease known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c228d4e3f9f6beb72a1f71212e9717ad
https://doi.org/10.1101/157354
https://doi.org/10.1101/157354
Autor:
Michele Trovato, Giuseppe Forte, C. Gadaleta, Benedetto Aluisio, F. Ciasca, C. Vergine, Maria Dicorato, A. Sallati
Publikováno v:
2017 14th International Conference on the European Energy Market (EEM).
Interactions between electricity market models and network models are more and more investigated due to higher international market integration and operation security concerns. In this paper, a procedure for flow-based analysis according to market re