Zobrazeno 1 - 7 of 7 pro vyhledávání: '"C. G. Paris"'
1
Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors
Autor: Wei Qi, C G Paris, David A. Ruddy, Michelle Lira, J Harari, Daniel King, Tomas Rejtar, Huili Zhai, V Saenz-Vash, Zhengtian Yu, Nicholas Keen, A Q Hassan, Fang Shen, Veronica Gibaja, Joshua M. Korn, Ho Man Chan
Publikováno v: Oncogene
The histone methyltransferase Enhancer of Zeste Homolog 2 (EZH2) is frequently dysregulated in cancers, and gain-of-function (GOF) EZH2 mutations have been identified in non-Hodgkin lymphomas. Small-molecule inhibitors against EZH2 demonstrated anti-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8996d2e21185249704b423c3a6253716
http://europepmc.org/articles/PMC4744243
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2
Bioactive conformation of stromelysin inhibitors determined by transferred nuclear Overhauser effects
Autor: Richard Melton, Shou-Ih Hu, Nina C. Gonnella, C G Paris, Regine Bohacek, Vishwas Ganu, István Kolossváry, C Winter, Xiaolu Zhang
The transferred nuclear Overhauser effect has been used to determine the biologically active conformations of two stromelysin inhibitors. Both inhibitors used in this study were hydroxamic acids generated via chemical synthesis. These structures, rep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a37f3bdf369ef5670c2d109a22d4ad
https://europepmc.org/articles/PMC42760/
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5
Purification and properties of aromatic amino acid aminotransferase from Klebsiella aerogenes
Autor: B Magasanik, C G Paris
Publikováno v: Journal of Bacteriology. 145:266-271
We describe the complete purification of aromatic aminotransferase I, the enzyme responsible for the ability of Klebsiella aerogenes to use tryptophan and phenylalanine as sole sources of nitrogen, as well as the partial purification of aromatic amin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c182b9d6a54d24e8d59423f1730991
https://doi.org/10.1128/jb.145.1.266-271.1981
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7
Tryptophan metabolism in Klebsiella aerogenes: regulation of the utilization of aromatic amino acids as sources of nitrogen
Autor: C G Paris, B Magasanik
Publikováno v: Journal of bacteriology. 145(1)
Klebsiella aerogenes utilized aromatic amino acids as sole sources of nitrogen but not as sole sources of carbon. K. aerogenes abstracted the alpha-amino group of these compounds by transamination and excreted the arylpyruvate portions into the mediu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5987e9f7332c18fd8bc3cc7d5ea773eb
https://pubmed.ncbi.nlm.nih.gov/6109705
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