Zobrazeno 1 - 10
of 49
pro vyhledávání: '"C. G. Mackworth-Young"'
Autor:
A. A. Jilani, C. G. Mackworth-Young
Publikováno v:
International Journal of Rheumatology, Vol 2015 (2015)
Background. Autoantibodies to citrullinated peptides have been shown to be valuable in the diagnosis of rheumatoid arthritis (RA). The expanding repertoire of antibodies to citrullinated peptide antigens (ACPA) has been a topic of great interest in r
Externí odkaz:
https://doaj.org/article/7530779307b847d89bc482670d7f49fe
Autor:
C. G. Mackworth-Young
Publikováno v:
Clinical and Experimental Immunology. 136:393-401
It is 20 years since the use of a radioimmunoassay enabled an association to be described between antibodies to the anionic phospholipid cardiolipin and a set of clinical features [1]. These features, which included thrombosis – both venous and art
Publikováno v:
Clinical and Experimental Immunology. 134:420-425
SUMMARYThe immune system mounts antibody responses using few of the available immunoglobulin variable region (IgV) genes with some, such as the V3-23 heavy chain gene, regularly over-represented in responses to many antigens. The reasons for the over
Autor:
C G Mackworth-Young, Ian J. Harmer, A. Kaminski, Marianne Brüggemann, P. Charles, Rizgar A. Mageed
Publikováno v:
Immunology. 88:174-182
To elucidate the molecular basis for the ability of antibodies encoded by the human VH26 heavy-chain variable region gene to react with diverse antigens, we have generated 34 hybridomas secreting chimaeric monoclonal antibodies (human mu heavy chain/
Publikováno v:
Arthritis & Rheumatism. 38:1068-1076
Objective. To investigate the origins of antiphospholipid antibodies associated with thrombosis and other disorders that are found in patients with systemic lupus erythematosus and primary antiphospholipid syndrome (APS). Methods. Characterization, i
Publikováno v:
Europe PubMed Central
Coeliac disease may account for malabsorption in scleroderma patients even when tests suggest bacterial overgrowth. A small bowel biopsy is essential.
Publikováno v:
Postgraduate medical journal. 86(1016)
Background Current treatment for osteoarthritis (OA) is limited. Many patients with OA of the hand have areas of tender subcutaneous thickening in the forearm and upper scapular region. A pilot study showed an improvement in pain from OA at the first
Publikováno v:
Clinical and Experimental Immunology. 90:422-427
SUMMARY Autoantibodies against cyclophilin, a cyclosporin A binding protein, were detected in sera of 29 of 46 (63%) patients with systemic lupus erythematosus and 14 of 40 (35%) Lyme disease patients. The antibodies are directed against the denature
Autor:
C G Mackworth-Young, Y Shoenfeld
Publikováno v:
Journal of Autoimmunity. 3:389-392
Autor:
C. G. Mackworth-Young
Publikováno v:
Clinical and Experimental Immunology. 79:78-82
SUMMARY Monoclonal IgM autoantibodies have previously been generated from a patient with lepromatous leprosy. Polyclonal anti-idiotypes raised against two of these monoclonal antibodies (8E7 and TH9) were used in an immunoassay to detect the presence