Zobrazeno 1 - 10
of 49
pro vyhledávání: '"C. G. Knight"'
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238123 (2020)
An effective and pain-free killing method is required to achieve the goal of euthanasia, a "good death". Overdose of sodium pentobarbital (PB) by intraperitoneal (IP) injection is a widely accepted technique in laboratory rats, but questions remain r
Externí odkaz:
https://doaj.org/article/6426f26da8474eae9f87f771a2d36784
Genes encoding resistance to stressors, such as antibiotics or environmental pollutants, are widespread across microbiomes, often encoded on mobile genetic elements. Yet despite their prevalence, the impact of resistance genes and their mobility upon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07519c0026f9e9b0ee6bb0706b759896
https://doi.org/10.1101/2022.02.25.481914
https://doi.org/10.1101/2022.02.25.481914
Autor:
Victoria Alcock, K. Relph, Mike J. Bickle, Alasdair C. G. Knight, Christina S. Larkin, Edward T. Tipper, Linshu Feng, J. Jotautas Baronas, Emily I. Stevenson, Robert G. Hilton, Genevieve Hughes
Publikováno v:
Proc Natl Acad Sci U S A
Rivers carry the dissolved and solid products of silicate mineral\ud weathering, a process that removes CO2 from the atmosphere and\ud provides a key negative climate feedback over geological timescales.\ud Here we show that in some river systems, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60876de52e5b5e43199f27d11505e9e5
https://doi.org/10.1073/pnas.2016430118
https://doi.org/10.1073/pnas.2016430118
We investigate the effect of selection in a meta-genetic algo- rithm designed to optimize mutation rate control, based on the fitness of sequences relative to a defined optimum, in asexual evolution. Multiple innovations in the algorithm are required
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2295::d5b024204c61d5b330488a7d0162daec
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:276229
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:276229
Autor:
K. BRUCE JONES, M. S. NASH, T. G. WADE, J. WALKER, A. C. NEALE, F. MUELLER, S. HAMANN, R. JONGMAN, S. NEDKOV, W. G. KEPNER, C. G. KNIGHT, ZURLINI, Giovanni, ZACCARELLI, NICOLA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______4034::e4d2f1fbefb7e9f34193ee52f0a8e68c
https://hdl.handle.net/11587/117745
https://hdl.handle.net/11587/117745
Autor:
C G, Knight, X X, Zhang, A, Gunn, T, Brenner, R W, Jackson, S R, Giddens, S, Prabhakar, N, Zitzmann, P B, Rainey
Publikováno v:
Environmental microbiology reports. 2(3)
Traits used by bacteria to enhance ecological performance in natural environments are not well understood. Recognizing that the saprophytic plant-colonizing bacterium Pseudomonas fluorescens SBW25 experiences temperatures in its natural environment s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25a41b506953a83aaf5219e9f11080d0
https://pubmed.ncbi.nlm.nih.gov/23766112
https://pubmed.ncbi.nlm.nih.gov/23766112
Many biological characteristics of evolutionary interest are not scalar variables but continuous functions. Given a dataset of function-valued traits generated by evolution, we develop a practical, statistical approach to infer ancestral function-val
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2295::0c1373be5c0f684433540b75bd88025c
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:186480
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:186480
Publikováno v:
Biochemical Journal. 308:145-150
The substrate-size specificity of human thimet oligopeptidase (EC 3.4.24.15) was investigated with oligomers of glycyl-prolyl-leucine (GPL)n where n = 2, 3, 4 and 5. These peptides were cleaved only at Leu-Gly bonds to give GPL as the single final pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06603bd73c5687c6281b96f9d7cdc114
https://doi.org/10.1042/bj3080145
https://doi.org/10.1042/bj3080145
Autor:
Frances Willenbrock, Susan J. Atkinson, Andrew J. P. Docherty, C. G. Knight, Mark I. Cockett, J A Allan, Quang Nguyen, Gillian Murphy
Publikováno v:
Journal of Biological Chemistry. 269:6632-6636
The properties of a deletion mutant delta V191-Q364 of gelatinase A, which represents the removal of the fibronectin-like type II repeats defined by exons 5-7, were compared with those of full-length gelatinase A. Both enzymes underwent self-activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff2839a7373ddc010100f16dea93db9c
https://doi.org/10.1016/s0021-9258(17)37419-7
https://doi.org/10.1016/s0021-9258(17)37419-7
Publikováno v:
Scopus-Elsevier
Pitrilysin (EC 3.4.99.44) has been purified from an over-expressing strain of Escherichia coli. A 13-residue quenched-fluorescent-peptide substrate for the enzyme has been synthesized, and found also to be cleaved by the homologous enzyme, insulinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86869445796c016c8f9257637c1a9890
https://doi.org/10.1042/bj2900601
https://doi.org/10.1042/bj2900601